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Basic Structure Sequence
Align DNA/Protein Distributions
Statistics Definitions Manual
Numbering Schemes & Region Definitions Canonical Classes
Scheme name Chain Type
Chothia numbering H1 H2 H3 H4 H5 H6 H6A H6B H6C H6D H7 H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24
REGIONS:  CHOTHIA
HFR1
ABM
HFR1
KABAT
HFR1
CONTACT
HFR1
H25 H26 H27 H28 H29 H30 H31 H31A H31B H31C H31D H31E H31F H31G H31H H32 H33 H34 H35 H36 H37 H38 H39 H40 H41 H42 H43 H44
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
H45 H46 H47 H48 H49 H50 H51 H52 H52A H52B H52C H52D H52E H52F H52G H53 H54 H55 H56 H57 H58 H59 H60 H61 H62 H63 H64 H65 H66
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
H67 H68 H69 H70 H71 H72 H73 H74 H75 H76 H77 H78 H79 H80 H81 H82 H82A H82B H82C H82D H82E H83 H84 H85 H86 H87 H88 H89 H90
HFR3
HFR3
HFR3
HFR3
H91 H92 H93 H94 H95 H96 H97 H98 H99 H100 H100A H100B H100C H100D H100E H100F H100G H100H H100I H100J H100K H100L H100M
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
H100N H100O H100P H100Q H100R H100S H100T H101 H102 H103 H104 H105 H106 H107 H108 H109 H110 H111 H112 H113 H114
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
   
 CDR
   
 Framework
    Potential insertion site
Martin numbering H1 H2 H3 H4 H5 H6 H7 H7A H7B H7C H7D H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24
REGIONS:  CHOTHIA
HFR1
ABM
HFR1
KABAT
HFR1
CONTACT
HFR1
H25 H26 H27 H28 H29 H30 H31 H31A H31B H31C H31D H31E H31F H31G H31H H32 H33 H34 H35 H36 H37 H38 H39 H40 H41 H42 H43 H44
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
H45 H46 H47 H48 H49 H50 H51 H52 H52A H52B H52C H52D H52E H52F H52G H53 H54 H55 H56 H57 H58 H59 H60 H61 H62 H63 H64 H65 H66
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
H67 H68 H69 H70 H71 H72 H72A H72B H72C H72D H72E H73 H74 H75 H76 H77 H78 H79 H80 H81 H82 H83 H84 H85 H86 H87 H88 H89 H90
HFR3
HFR3
HFR3
HFR3
H91 H92 H93 H94 H95 H96 H97 H98 H99 H100 H100A H100B H100C H100D H100E H100F H100G H100H H100I H100J H100K H100L H100M
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
H100N H100O H100P H100Q H100R H100S H100T H101 H102 H103 H104 H105 H106 H107 H108 H109 H110 H111 H112 H113 H114
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
   
 CDR
   
 Framework
    Potential insertion site
Kabat numbering H1 H2 H3 H4 H5 H6 H6A H6B H6C H6D H7 H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24
REGIONS:  CHOTHIA
HFR1
ABM
HFR1
KABAT
HFR1
CONTACT
HFR1
H25 H26 H27 H28 H29 H30 H31 H32 H33 H34 H35 H35A H35B H35C H35D H35E H35F H35G H35H H36 H37 H38 H39 H40 H41 H42 H43 H44
HFR1
CDR-H1
CDR-H1 † †
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
H45 H46 H47 H48 H49 H50 H51 H52 H52A H52B H52C H52D H52E H52F H52G H53 H54 H55 H56 H57 H58 H59 H60 H61 H62 H63 H64 H65 H66
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
H67 H68 H69 H70 H71 H72 H73 H74 H75 H76 H77 H78 H79 H80 H81 H82 H82A H82B H82C H82D H82E H83 H84 H85 H86 H87 H88 H89 H90
HFR3
HFR3
HFR3
HFR3
H91 H92 H93 H94 H95 H96 H97 H98 H99 H100 H100A H100B H100C H100D H100E H100F H100G H100H H100I H100J H100K H100L H100M
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
H100N H100O H100P H100Q H100R H100S H100T H101 H102 H103 H104 H105 H106 H107 H108 H109 H110 H111 H112 H113 H114
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
   
 CDR
   
 Framework
    Potential insertion site
† In the Kabat numbering scheme, the Chothia CDR-H1 loop ends at H32 if there is no insertion at H35. Otherwise it ends at H33 to H35E depending on the length of the insertion at H35: it ends at H33, H34, H35, H35A, H35B, H35C, H35D, H35E if the length of the insertion is 1, 2, 3, 4, 5, 6, 7 or 8 residues, respectively.
Chothia numbering H1 H2 H3 H4 H5 H6 H6A H6B H6C H6D H7 H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24
Martin numbering H1 H2 H3 H4 H5 H6 H7 H7A H7B H7C H7D H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24
Kabat numbering H1 H2 H3 H4 H5 H6 H6A H6B H6C H6D H7 H8 H9 H10 H11 H12 H13 H14 H15 H16 H17 H18 H19 H20 H21 H22 H23 H24
REGIONS:  CHOTHIA
HFR1
ABM
HFR1
KABAT
HFR1
CONTACT
HFR1
H25 H26 H27 H28 H29 H30 H31 H31A H31B H31C H31D H31E H31F H31G H31H H32 H33 H34 H35 H36 H37 H38 H39 H40 H41 H42 H43 H44
H25 H26 H27 H28 H29 H30 H31 H31A H31B H31C H31D H31E H31F H31G H31H H32 H33 H34 H35 H36 H37 H38 H39 H40 H41 H42 H43 H44
H25 H26 H27 H28 H29 H30 H31 H32 H33 H34 H35 H35A H35B H35C H35D H35E H35F H35G H35H H36 H37 H38 H39 H40 H41 H42 H43 H44
HFR1
CDR-H1
CDR-H1 † † † † † † † †
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
HFR1
CDR-H1
HFR2
H45 H46 H47 H48 H49 H50 H51 H52 H52A H52B H52C H52D H52E H52F H52G H53 H54 H55 H56 H57 H58 H59 H60 H61 H62 H63 H64 H65 H66
H45 H46 H47 H48 H49 H50 H51 H52 H52A H52B H52C H52D H52E H52F H52G H53 H54 H55 H56 H57 H58 H59 H60 H61 H62 H63 H64 H65 H66
H45 H46 H47 H48 H49 H50 H51 H52 H52A H52B H52C H52D H52E H52F H52G H53 H54 H55 H56 H57 H58 H59 H60 H61 H62 H63 H64 H65 H66
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
HFR2
CDR-H2
HFR3
H67 H68 H69 H70 H71 H72 H73 H74 H75 H76 H77 H78 H79 H80 H81 H82 H82A H82B H82C H82D H82E H83 H84 H85 H86 H87 H88 H89 H90
H67 H68 H69 H70 H71 H72 H72A H72B H72C H72D H72E H73 H74 H75 H76 H77 H78 H79 H80 H81 H82 H83 H84 H85 H86 H87 H88 H89 H90
H67 H68 H69 H70 H71 H72 H73 H74 H75 H76 H77 H78 H79 H80 H81 H82 H82A H82B H82C H82D H82E H83 H84 H85 H86 H87 H88 H89 H90
HFR3
HFR3
HFR3
HFR3
H91 H92 H93 H94 H95 H96 H97 H98 H99 H100 H100A H100B H100C H100D H100E H100F H100G H100H H100I H100J H100K H100L H100M
H91 H92 H93 H94 H95 H96 H97 H98 H99 H100 H100A H100B H100C H100D H100E H100F H100G H100H H100I H100J H100K H100L H100M
H91 H92 H93 H94 H95 H96 H97 H98 H99 H100 H100A H100B H100C H100D H100E H100F H100G H100H H100I H100J H100K H100L H100M
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
HFR3
CDR-H3
H100N H100O H100P H100Q H100R H100S H100T H101 H102 H103 H104 H105 H106 H107 H108 H109 H110 H111 H112 H113 H114
H100N H100O H100P H100Q H100R H100S H100T H101 H102 H103 H104 H105 H106 H107 H108 H109 H110 H111 H112 H113 H114
H100N H100O H100P H100Q H100R H100S H100T H101 H102 H103 H104 H105 H106 H107 H108 H109 H110 H111 H112 H113 H114
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
CDR-H3
HFR4
   
 CDR
   
 Framework
    Potential insertion site
† In the Kabat numbering scheme, the Chothia CDR-H1 loop ends at H32 if there is no insertion at H35. Otherwise it ends at H33 to H35E depending on the length of the insertion at H35: it ends at H33, H34, H35, H35A, H35B, H35C, H35D, H35E if the length of the insertion is 1, 2, 3, 4, 5, 6, 7 or 8 residues, respectively.
Chothia numbering L1 L2 L3 L4 L5 L6 L7 L8 L9 L10 L11 L12 L13 L14 L15 L16 L17 L18 L19 L20 L21 L22
REGIONS:  CHOTHIA
LFR1
ABM
LFR1
KABAT
LFR1
CONTACT
LFR1
L23 L24 L25 L26 L27 L28 L29 L30 L30A L30B L30C L30D L30E L30F L31 L32 L33 L34 L35 L36 L37 L38 L39 L39A L40 L41 L42 L43 L44
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
L45 L46 L47 L48 L49 L50 L51 L52 L53 L54 L54A L54B L54C L54D L54E L55 L56 L57 L58 L59 L60 L61 L62 L63 L64 L65 L66
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
L66A L66B L66C L66D L66E L66F L66G L66H L67 L68 L69 L70 L71 L72 L73 L74 L75 L76 L77 L78 L79 L80 L81 L82 L83 L84
LFR3
LFR3
LFR3
LFR3
L85 L86 L87 L88 L89 L90 L91 L92 L93 L94 L95 L95A L95B L95C L95D L95E L95F L96 L97 L98 L99 L100 L101 L102 L103 L104
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
L105 L106 L106A L107 L108 L109 L110 L111
LFR4
LFR4
LFR4
LFR4
   
 CDR
   
 Framework
    Potential insertion site
Martin numbering L1 L2 L3 L4 L5 L6 L7 L8 L9 L10 L11 L12 L13 L14 L15 L16 L17 L18 L19 L20 L21 L22
REGIONS:  CHOTHIA
LFR1
ABM
LFR1
KABAT
LFR1
CONTACT
LFR1
L23 L24 L25 L26 L27 L28 L29 L30 L30A L30B L30C L30D L30E L30F L31 L32 L33 L34 L35 L36 L37 L38 L39 L40 L40A L41 L42 L43 L44
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
L45 L46 L47 L48 L49 L50 L51 L52 L52A L52B L52C L52D L52E L53 L54 L55 L56 L57 L58 L59 L60 L61 L62 L63 L64 L65 L66
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
L67 L68 L68A L68B L68C L68D L68E L68F L68G L68H L69 L70 L71 L72 L73 L74 L75 L76 L77 L78 L79 L80 L81 L82 L83 L84
LFR3
LFR3
LFR3
LFR3
L85 L86 L87 L88 L89 L90 L91 L92 L93 L94 L95 L95A L95B L95C L95D L95E L95F L96 L97 L98 L99 L100 L101 L102 L103 L104
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
L105 L106 L106A L107 L108 L109 L110 L111
LFR4
LFR4
LFR4
LFR4
   
 CDR
   
 Framework
    Potential insertion site
Kabat numbering L1 L2 L3 L4 L5 L6 L7 L8 L9 L10 L11 L12 L13 L14 L15 L16 L17 L18 L19 L20 L21 L22
REGIONS:  CHOTHIA
LFR1
ABM
LFR1
KABAT
LFR1
CONTACT
LFR1
L23 L24 L25 L26 L27 L27A L27B L27C L27D L27E L27F L28 L29 L30 L31 L32 L33 L34 L35 L36 L37 L38 L39 L39A L40 L41 L42 L43 L44
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1 †; †;
CDR-L1
LFR2
L45 L46 L47 L48 L49 L50 L51 L52 L53 L54 L54A L54B L54C L54D L54E L55 L56 L57 L58 L59 L60 L61 L62 L63 L64 L65 L66
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
L66A L66B L66C L66D L66E L66F L66G L66H L67 L68 L69 L70 L71 L72 L73 L74 L75 L76 L77 L78 L79 L80 L81 L82 L83 L84
LFR3
LFR3
LFR3
LFR3
L85 L86 L87 L88 L89 L90 L91 L92 L93 L94 L95 L95A L95B L95C L95D L95E L95F L96 L97 L98 L99 L100 L101 L102 L103 L104
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
L105 L106 L106A L107 L108 L109 L110 L111
LFR4
LFR4
LFR4
LFR4
   
 CDR
   
 Framework
    Potential insertion site
† In the Kabat numbering scheme, the Contact CDR-L1 loop starts at L30 if there is no insertion at L27. Otherwise it starts at L27C to L29 depending on the length of the insertion at L27: it ends at L29, L28, L27F, L27E, L27D, L27C if the length of the insertion is 1, 2, 3, 4, 5 or 6 residues, respectively.
Chothia numbering L1 L2 L3 L4 L5 L6 L7 L8 L9 L10 L11 L12 L13 L14 L15 L16 L17 L18 L19 L20 L21 L22
Martin numbering L1 L2 L3 L4 L5 L6 L7 L8 L9 L10 L11 L12 L13 L14 L15 L16 L17 L18 L19 L20 L21 L22
Kabat numbering L1 L2 L3 L4 L5 L6 L7 L8 L9 L10 L11 L12 L13 L14 L15 L16 L17 L18 L19 L20 L21 L22
REGIONS:  CHOTHIA
LFR1
ABM
LFR1
KABAT
LFR1
CONTACT
LFR1
L23 L24 L25 L26 L27 L28 L29 L30 L30A L30B L30C L30D L30E L30F L31 L32 L33 L34 L35 L36 L37 L38 L39 L39A L40 L41 L42 L43 L44
L23 L24 L25 L26 L27 L28 L29 L30 L30A L30B L30C L30D L30E L30F L31 L32 L33 L34 L35 L36 L37 L38 L39 L40 L40A L41 L42 L43 L44
L23 L24 L25 L26 L27 L27A L27B L27C L27D L27E L27F L28 L29 L30 L31 L32 L33 L34 L35 L36 L37 L38 L39 L39A L40 L41 L42 L43 L44
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1
LFR2
LFR1
CDR-L1 †; †; †; †; †; †; †; †;
CDR-L1
LFR2
L45 L46 L47 L48 L49 L50 L51 L52 L53 L54 L54A L54B L54C L54D L54E L55 L56 L57 L58 L59 L60 L61 L62 L63 L64 L65 L66
L45 L46 L47 L48 L49 L50 L51 L52 L52A L52B L52C L52D L52E L53 L54 L55 L56 L57 L58 L59 L60 L61 L62 L63 L64 L65 L66
L45 L46 L47 L48 L49 L50 L51 L52 L53 L54 L54A L54B L54C L54D L54E L55 L56 L57 L58 L59 L60 L61 L62 L63 L64 L65 L66
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
LFR2
CDR-L2
LFR3
L66A L66B L66C L66D L66E L66F L66G L66H L67 L68 L69 L70 L71 L72 L73 L74 L75 L76 L77 L78 L79 L80 L81 L82 L83 L84
L67 L68 L68A L68B L68C L68D L68E L68F L68G L68H L69 L70 L71 L72 L73 L74 L75 L76 L77 L78 L79 L80 L81 L82 L83 L84
L66A L66B L66C L66D L66E L66F L66G L66H L67 L68 L69 L70 L71 L72 L73 L74 L75 L76 L77 L78 L79 L80 L81 L82 L83 L84
LFR3
LFR3
LFR3
LFR3
L85 L86 L87 L88 L89 L90 L91 L92 L93 L94 L95 L95A L95B L95C L95D L95E L95F L96 L97 L98 L99 L100 L101 L102 L103 L104
L85 L86 L87 L88 L89 L90 L91 L92 L93 L94 L95 L95A L95B L95C L95D L95E L95F L96 L97 L98 L99 L100 L101 L102 L103 L104
L85 L86 L87 L88 L89 L90 L91 L92 L93 L94 L95 L95A L95B L95C L95D L95E L95F L96 L97 L98 L99 L100 L101 L102 L103 L104
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
LFR3
CDR-L3
LFR4
L105 L106 L106A L107 L108 L109 L110 L111
L105 L106 L106A L107 L108 L109 L110 L111
L105 L106 L106A L107 L108 L109 L110 L111
LFR4
LFR4
LFR4
LFR4
   
 CDR
   
 Framework
    Potential insertion site
† In the Kabat numbering scheme, the Contact CDR-L1 loop starts at L30 if there is no insertion at L27. Otherwise it starts at L27C to L29 depending on the length of the insertion at L27: it ends at L29, L28, L27F, L27E, L27D, L27C if the length of the insertion is 1, 2, 3, 4, 5 or 6 residues, respectively.
Region Canonical method
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 H2 H4 H20 H22 H24 H26 H28 H29 H31A H32 H33 H34 H35 H36 H48 H50 H51 H53 H69 H76 H78 H80 H90 H92 H94 H96 H102
1/10A 2fbj_H 10 V
I
G
 L
V
 L
I
M
V
 C
 T
A
V
G
S
 G
 I
F
L
S
 I
H
Y
F
T
N
C
E
D
 Y
A
W
G
T
L
V
 I
V
M
W
 H
E
N
Q
S
Y
T
 W
 I
M
V
L
 L
I
V
T
S
N
 I
L
F
M
V
 A
L
V
Y
F
 L
M
 Y
F
 C
 R
K
G
S
H
N
 Y
H
V
I
S
D
G
2/11A 1baf_H 11 V
 L
 C
 V
 G
 I
 D
 A
 W
 W
 M
 Y
 Y
 I
 N
 F
 L
 C
 W
3/12A 1ggi_H 12 L
 C
 V
F
 G
 S
 I
L
 W
V
 W
 M
L
 Y
W
 F
V
 I
L
 C
?/10C 1nbv_H 10 V
 P
 L
 C
 A
 G
 F
 N
 A
 M
 N
 W
 V
 I
 I
 L
 L
 Y
 C
 R
 Y
?/10D 1fig_H 10 V
 L
 I
 C
 A
 G
 L
 H
 N
 I
 N
 W
 I
 I
 L
 L
 M
 Y
 C
 R
 Y
Kabat position, permitted amino acids
Class References Rep.
Structure		 Loop
Length		 H26 H27 H29 H34 H35 H35A H92 H94
1
(2); Require H92, ignore H24, add RGHTK to H94 (3)
2fbj_H 10 G
 G
F
Y
 I
F
V
L
 M
I
L
V
T
W
 C
 R
T
K
H
G
L
1B
(4) (Based on (1), (2) and (3))
7fab_H 10 G
 T
D
 I
F
 W
S
 C
 R
N
2
(2); Require H92 (3)
1baf_H 11 G
 F
Y
G
 L
I
 C
W
V
 C
 H
R
3
(2); Require H92 (3)
- 12 G
 F
G
D
 L
I
V
 V
W
 C
 R
H
(1) Chothia et al. Nature, 342(1989)877-883
(2) Chothia et al. JMB, 227(1992)799-817
(3) Extra definitions by Steven Searle, Bath University
(4) Extra definitions by Andrew Martin, UCL
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 H24 H26 H27 H29 H34 H94 H96
1 2fbj_H 10 T
A
V
G
S
 G
 F
Y
T
G
 F
L
I
V
 M
I
V
L
T
 R
K
T
A
1' 3hfm_H 10 G
 S
D
 F
I
 Y
W
 R
N
2 - 11 V
F
 G
 G
F
Y
 I
L
 C
W
 H
R
3 - 12 V
F
G
 G
 F
G
D
 I
L
V
 W
V
 H
R
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 H33 H47 H50 H51 H52 H53 H54 H55 H56 H58 H59 H69 H71 H78
1/9A 1gig_H 9 W
Y
 I
M
V
 G
 Y
L
 I
M
 R
K
V
2/10A 1bbd_H 10 Y
W
G
A
T
L
 W
Y
 R
E
W
Y
G
Q
V
L
N
K
A
 L
I
 D
L
N
S
Y
 A
G
Y
S
K
T
N
 N
S
T
K
D
G
 Y
R
E
D
G
V
S
A
 K
N
T
S
D
R
G
F
Y
 Y
 I
F
L
M
 V
A
L
 A
L
V
3/10B 1igc_H 10 A
G
V
Y
W
 W
 G
T
Y
F
I
E
V
 I
V
 S
F
W
H
 D
G
S
N
 S
G
 S
Y
T
N
D
R
 G
Y
H
F
D
N
 Y
 I
 R
 L
4/12A 1mcp_H 12 W
 F
A
 I
S
 Y
 I
V
 R
 L
?/10E 6fab_H 10 G
 W
 Y
 N
 N
 G
 N
 Y
 A
 Y
 L
 V
 A
?/10F 1fig_H 10 N
 W
 N
 I
 D
 Y
 Y
 G
 N
 F
 L
 V
 L
?/12B 4fab_H 12 W
 R
Q
 I
 Y
 I
 R
 L
V
Kabat position, permitted amino acids
Class References Rep.
Structure		 Loop
Length		 H52A H54 H55 H71
1
(2)
1gig_H 9 D
G
 K
R
V
I
2
(2); Allow H71=V (4)
1bbd_H 10 P
T
A
 G
S
 A
T
L
V
3
(2)
1igc_H 10 G
S
N
D
 R
4
(2); Allow H54=G (3)
1mcp_H 12 S
K
N
G
 Y
 R
(2) Chothia et al. JMB, 227(1992)799-817
(3) Extra definitions by Steven Searle, Bath University
(4) Extra definitions by Andrew Martin, UCL
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 H52A H54 H55 H71
1 1gig_H 9 G
D
 R
K
V
I
2 - 10 P
T
A
 G
S
 A
L
T
3 - 10 D
P
 G
N
D
S
 G
S
 R
4 1mcp_H 12 K
S
 Y
 R
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 L2 L4 L23 L24 L25 L26 L27 L28 L29 L30 L30A L30B L30C L30D L31 L32 L33 L34 L35 L36 L46 L48 L49 L51 L66 L71 L88 L90 L91 L92 L93
1/10A 2fbj_L 10 I
 L
 C
 A
 V
 L
M
 W
 Y
 C
 Q
 S
Y
R
2/11A 1ikf_L 11 I
 M
L
 C
 A
 S
 N
S
D
E
 I
V
 L
V
 A
G
N
S
H
V
F
 W
 Y
L
F
 L
R
V
 Y
H
F
K
 A
T
G
V
 Y
F
 H
Q
 G
S
N
T
R
E
A
3/17A 1hil_A 17 I
 M
 C
 L
 L
 W
 Y
F
 N
 N
S
4/16A 1rmf_L 16 V
 M
L
 C
 S
P
 S
N
 Q
 L
I
 H
L
 S
 N
D
S
 G
 Y
S
 L
F
 H
E
N
 W
 V
 F
 C
 Q
 T
S
 H
5/13A 2fb4_L 13 S
 L
 C
 G
 N
D
 I
 G
 V
 W
 D
N
 A
 C
 A
 V
D
6/14A - 14 S
 L
 C
 G
 S
 S
 N
 I
 H
 N
 V
 W
 I
 N
 K
 A
 C
 S
 R
7/14B 1gig_L 14 A
Q
 V
 C
 S
 G
 A
T
 V
 N
 Y
H
 A
 W
 I
 T
 L
 A
 C
 L
 S
N
?/11B 8fab_A 11 L
 C
 A
 N
 L
 P
 A
 Y
 W
 Y
 M
 Y
 D
 V
 A
 N
?/12A 1fig_L 12 N
 L
 C
 A
 V
 L
 W
 Y
 C
 Q
 Y
 G
?/14C 2mcg_1 14 S
 L
 C
 T
 S
 D
 V
 N
 Y
 V
 W
 I
 V
 K
 A
 C
 S
 G
?/14D - 14 S
 L
 C
 T
 S
 D
 V
 N
 Y
 V
 W
 I
 V
 K
 A
 C
 S
 G
?/14E 1mcw_W 14 S
 L
 C
 H
 S
 D
 V
 N
 S
 I
 W
 I
 V
 K
 A
 C
 S
 S
?/15A 1acy_L 15 I
 M
L
 C
 R
 A
 S
 S
 V
 D
S
 G
 M
I
 H
 W
 A
 F
 C
 Q
H
 N
R
 E
?/15B 1ggi_L 15 I
 L
 C
 R
 A
 S
 S
 V
 D
 G
 L
 H
 W
 S
 F
 C
 Q
 N
 E
?/16C 2jel_L 16 V
 M
 C
 S
 S
 Q
 I
 H
 G
 N
 G
 Y
 L
 E
 W
 I
 F
 C
 Q
 S
 H
Kabat position, permitted amino acids
Class References Rep.
Structure		 Loop
Length		 L2 L3 L23 L25 L27B L28 L29 L30 L33 L35 L71
1
(1); Require L23, L35 (3)
2fbj_L 10 I
 C
 A
 V
 L
M
 W
 Y
2
(1); Require L23, L35 (3)
1ikf_L 11 I
 C
 A
 I
V
 L
 W
 Y
F
3
(1); Require L23, L35 (3)
1hil_A 17 I
 C
 S
 L
 L
 W
 Y
F
4
(1); Require L23, L35 (3)
1rmf_L 16 V
 C
 S
 L
 L
 W
 Y
F
5
(3)
2fb4_L 13 S
 C
 G
 I
 V
 W
 A
6
- 14 G
 I
 V
 A
7
- 14 S
 V
 A
 A
8*
(3)
8fab_A 11 E
 C
 S
A
 P
 A
 W
 V
S
A
(1) Chothia et al. Nature, 342(1989)877-883
(3) Extra definitions by Steven Searle, Bath University
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 L2 L25 L29 L30 L33 L71
1 2fbj_L 10 I
 A
 V
I
L
 L
M
 Y
F
2 1ikf_L 11 I
 A
 V
I
L
 L
V
 Y
F
3 1hil_A 17 I
 S
 V
I
L
 L
 Y
F
4 1rmf_L 16 V
 S
 L
 L
 F
5 2fb4_L 13 G
 I
 V
 A
6 - 14 G
 I
 V
 A
7 1gig_L 14 S
 V
 A
 A
8 1fig_L 12 N
 A
 V
 L
 Y
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 L23
1/7A 1lmk_A_ii 7 C
Kabat position, permitted amino acids
Class References Rep.
Structure		 Loop
Length		 L48 L64
1
(1)
1lmk_A_ii 7 I
V
 G
(1) Chothia et al. Nature, 342(1989)877-883
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 L48 L64
1 1lmk_A_ii 7 I
V
 G
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 L2 L3 L4 L28 L30 L31 L32 L33 L34 L36 L88 L89 L90 L91 L92 L93 L94 L95 L95A L96 L97 L98
1/9A 1tet_L 9 I
L
V
 V
Q
L
E
 M
L
 S
N
D
T
E
 D
L
Y
V
I
S
N
F
H
G
T
 S
N
T
K
G
 F
Y
N
A
H
S
R
 M
L
V
I
F
 C
 Q
S
G
F
L
 Q
N
H
 N
F
G
S
R
D
H
T
Y
V
 N
Y
W
T
S
R
Q
H
A
D
 E
N
G
H
T
S
R
A
 D
Y
T
V
L
H
N
I
W
P
S
 P
 P
L
Y
R
I
W
F
 T
 F
2/9B - 9 I
 V
 L
 S
 S
 S
 L
 C
 Q
 Q
 W
 T
 Y
 P
 L
 I
 T
 F
3/8A 1yqv_L 8 Y
 C
 Q
 Q
 W
 F
4/9C - 9 Q
S
 I
V
 V
L
 G
S
 V
I
 N
H
 H
N
 A
V
 C
 A
Q
 L
S
 W
Y
 S
D
 N
R
 N
S
 H
L
 W
R
 I
V
 F
5/11A 2fb4_L 11 L
 V
 C
 A
 A
 D
N
 V
G
 F
?/7A 1dfb_L 7 W
 A
 Y
 C
 Q
 Y
 F
?/8B 1eap_A 8 Y
 C
 L
 Q
 Y
 F
?/9D 1gig_L 9 A
 V
 V
 G
 V
 N
 Y
 A
 C
 A
 L
 W
 Y
 S
 N
 H
L
 W
 V
 F
?/9E 1fig_L 9 N
 V
 L
 S
 S
 T
 Y
 L
 C
 Q
 Q
 Y
 S
 G
 Y
 P
 L
 T
 F
?/9F 8fab_A 9 E
 L
 L
 N
 Q
 Y
 A
 C
 Q
 A
 W
 D
 N
 S
 A
 S
 I
 F
?/10A 1baf_L 10 L
 Y
 Y
 C
 Q
 Q
 W
 S
 P
 I
 T
 F
?/10B 1mcw_M 10 L
 Y
 Y
 C
 S
 S
 Y
 E
 N
 F
 V
 F
?/10C - 10 L
 Y
 Y
 C
 S
 S
 Y
 E
 N
 F
 V
 F
?/10D 1mcw_W 10 L
 S
 F
 C
 M
 S
 Y
 L
 S
 F
 V
 F
Kabat position, permitted amino acids
Class References Rep.
Structure		 Loop
Length		 L88 L90 L94 L95 L96
1
(1)
1tet_L 9 C
 Q
N
H
 P
2
(1)
2fbj_L 9 C
 Q
 P
3
(1)
1yqv_L 8 C
 Q
 P
(1) Chothia et al. Nature, 342(1989)877-883
Chothia position, permitted amino acids
Class Rep.
Structure		 Loop
Length		 L90 L94 L95 L96
1 1tet_L 9 Q
N
H
 P
2 2fbj_L 9 P
 L
3 1yqv_L 8 Q
 P
4 - 9 L
S
 N
S
 H
L
5 - 11 D
N
G