abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	M	1 - 1	1
HFR1	QVQLVETGGGLVQAGGSLRLSCAASGNIFS	2 - 31	30
CDR-H1	FNVMG	32 - 36	5
HFR2	WYRQAPGKQRELVA	37 - 50	14
CDR-H2	AITSGDTTTYADSVQG	51 - 66	16
HFR3	RFTISRDNAKNAVYLQMNSLTPEDTAVYFCNA	67 - 98	32
CDR-H3	RRNPINGPYYTTAY	99 - 112	14
HFR4	WGQGTQVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVETGGGLVQAGGSLRLSCAAS-----	2 - 26	25
	AbM	QVQLVETGGGLVQAGGSLRLSCAAS-----	2 - 26	25
	Kabat	QVQLVETGGGLVQAGGSLRLSCAASGNIFS	2 - 31	30
	Contact	QVQLVETGGGLVQAGGSLRLSCAASGNIF-	2 - 30	29
	IMGT	QVQLVETGGGLVQAGGSLRLSCAAS-----	2 - 26	25
CDR-H1	Chothia	GNIFSFN---	27 - 33	7
	AbM	GNIFSFNVMG	27 - 36	10
	Kabat	-----FNVMG	32 - 36	5
	Contact	----SFNVMG	31 - 36	6
	IMGT	GNIFSFNV--	27 - 34	8
HFR2	Chothia	VMGWYRQAPGKQRELVAAI	34 - 52	19
	AbM	---WYRQAPGKQRELVA--	37 - 50	14
	Kabat	---WYRQAPGKQRELVA--	37 - 50	14
	Contact	---WYRQAPGKQRE-----	37 - 47	11
	IMGT	-MGWYRQAPGKQRELVAA-	35 - 51	17
CDR-H2	Chothia	-----TSGDT---------	53 - 57	5
	AbM	---AITSGDTTT-------	51 - 59	9
	Kabat	---AITSGDTTTYADSVQG	51 - 66	16
	Contact	LVAAITSGDTTT-------	48 - 59	12
	IMGT	----ITSGDTT--------	52 - 58	7
HFR3	Chothia	TTYADSVQGRFTISRDNAKNAVYLQMNSLTPEDTAVYFCNA	58 - 98	41
	AbM	--YADSVQGRFTISRDNAKNAVYLQMNSLTPEDTAVYFCNA	60 - 98	39
	Kabat	---------RFTISRDNAKNAVYLQMNSLTPEDTAVYFCNA	67 - 98	32
	Contact	--YADSVQGRFTISRDNAKNAVYLQMNSLTPEDTAVYFC--	60 - 96	37
	IMGT	-TYADSVQGRFTISRDNAKNAVYLQMNSLTPEDTAVYFC--	59 - 96	38
CDR-H3	Chothia	--RRNPINGPYYTTAY	99 - 112	14
	AbM	--RRNPINGPYYTTAY	99 - 112	14
	Kabat	--RRNPINGPYYTTAY	99 - 112	14
	Contact	NARRNPINGPYYTTA-	97 - 111	15
	IMGT	NARRNPINGPYYTTAY	97 - 112	16
HFR4	Chothia	-WGQGTQVTVSS	113 - 123	11
	AbM	-WGQGTQVTVSS	113 - 123	11
	Kabat	-WGQGTQVTVSS	113 - 123	11
	Contact	YWGQGTQVTVSS	112 - 123	12
	IMGT	-WGQGTQVTVSS	113 - 123	11

Accession & Annotations

Accession	5j1s_C
Source	PDB 5j1s Submitted 29-MAR-2016 Updated 20-SEP-2017
Name	TORSINA-LULL1 COMPLEX, H. SAPIENS, BOUND TO VHH-BS2
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5j1t_C
References	DEMIRCIOGLU E., SOSA A., INGRAM J., PLOEGH L., SCHWARTZ U. 'STRUCTURES OF TORSINA AND ITS DISEASE-MUTANT COMPLEXED WITH AN ACTIVATOR REVEAL THE MOLECULAR BASIS FOR PRIMARY DYSTONIA.' ELIFE V. 5 2016 ESSN 2050-084X

Tools

Sequences

Amino Acid Sequence:

MQVQLVETGGGLVQAGGSLRLSCAASGNIFSFNVMGWYRQAPGKQRELVAAITSGDTTTY
ADSVQGRFTISRDNAKNAVYLQMNSLTPEDTAVYFCNARRNPINGPYYTTAYWGQGTQVT
VSS