abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	TG	1 - 2	2
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGKMSS	3 - 32	30
CDR-H1	RRCMA	33 - 37	5
HFR2	WFRQAPGKERERVA	38 - 51	14
CDR-H2	KLLTTSGSTYLADSVKG	52 - 68	17
HFR3	RFTISQNNAKSTVYLQMNSLKPEDTAMYYCAA	69 - 100	32
CDR-H3	DSFEDPTCTLVTSSGAFQY	101 - 119	19
HFR4	WGQGTQVTVSS	120 - 130	11
Tail	GSMDPGGSHHHHHHHH	130 - 146	16
			146

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	3 - 27	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	3 - 27	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGKMSS	3 - 32	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGKMS-	3 - 31	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	3 - 27	25
CDR-H1	Chothia	GKMSSRR---	28 - 34	7
	AbM	GKMSSRRCMA	28 - 37	10
	Kabat	-----RRCMA	33 - 37	5
	Contact	----SRRCMA	32 - 37	6
	IMGT	GKMSSRRC--	28 - 35	8
HFR2	Chothia	CMAWFRQAPGKERERVAKL	35 - 53	19
	AbM	---WFRQAPGKERERVA--	38 - 51	14
	Kabat	---WFRQAPGKERERVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-MAWFRQAPGKERERVAK-	36 - 52	17
CDR-H2	Chothia	-----LTTSGS---------	54 - 59	6
	AbM	---KLLTTSGSTY-------	52 - 61	10
	Kabat	---KLLTTSGSTYLADSVKG	52 - 68	17
	Contact	RVAKLLTTSGSTY-------	49 - 61	13
	IMGT	----LLTTSGST--------	53 - 60	8
HFR3	Chothia	TYLADSVKGRFTISQNNAKSTVYLQMNSLKPEDTAMYYCAA	60 - 100	41
	AbM	--LADSVKGRFTISQNNAKSTVYLQMNSLKPEDTAMYYCAA	62 - 100	39
	Kabat	---------RFTISQNNAKSTVYLQMNSLKPEDTAMYYCAA	69 - 100	32
	Contact	--LADSVKGRFTISQNNAKSTVYLQMNSLKPEDTAMYYC--	62 - 98	37
	IMGT	-YLADSVKGRFTISQNNAKSTVYLQMNSLKPEDTAMYYC--	61 - 98	38
CDR-H3	Chothia	--DSFEDPTCTLVTSSGAFQY	101 - 119	19
	AbM	--DSFEDPTCTLVTSSGAFQY	101 - 119	19
	Kabat	--DSFEDPTCTLVTSSGAFQY	101 - 119	19
	Contact	AADSFEDPTCTLVTSSGAFQ-	99 - 118	20
	IMGT	AADSFEDPTCTLVTSSGAFQY	99 - 119	21
HFR4	Chothia	-WGQGTQVTVSS	120 - 130	11
	AbM	-WGQGTQVTVSS	120 - 130	11
	Kabat	-WGQGTQVTVSS	120 - 130	11
	Contact	YWGQGTQVTVSS	119 - 130	12
	IMGT	-WGQGTQVTVSS	120 - 130	11

Accession & Annotations

Accession	5jds_B
Source	PDB 5jds Submitted 17-APR-2016 Updated 12-APR-2017
Name	CRYSTAL STRUCTURE OF PD-L1 COMPLEXED WITH A NANOBODY AT 1.7 ANGSTRON RESOLUTION
Organism	Camelidae
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	ZHANG F., WEI H., WANG X., BAI Y., WANG P., WU J., JIANG X., WANG Y., CAI H., XU T., ZHOU A. 'STRUCTURAL BASIS OF A NOVEL PD-L1 NANOBODY FOR IMMUNE CHECKPOINT BLOCKADE.' CELL DISCOV V. 3 17004 2017 ESSN 2056-5968

Tools

Sequences

Amino Acid Sequence:

TGQVQLQESGGGLVQPGGSLRLSCAASGKMSSRRCMAWFRQAPGKERERVAKLLTTSGST
YLADSVKGRFTISQNNAKSTVYLQMNSLKPEDTAMYYCAADSFEDPTCTLVTSSGAFQYW
GQGTQVTVSSGSMDPGGSHHHHHHHH