abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGSIFS	1 - 30	30
CDR-H1	LNDMG	31 - 35	5
HFR2	WYRQAPGKLRELVA	36 - 49	14
CDR-H2	AITSGGSTKYADSVKG	50 - 65	16
HFR3	RFTISRDNAKNTVYLQMNSLKAEDTAVYYCNA	66 - 97	32
CDR-H3	KVAGTFSIYDY	98 - 108	11
HFR4	WGQGTQVTVSS	109 - 119	11
Tail	HHHHHH	119 - 125	6
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGSIFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGSIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSIFSLN---	26 - 32	7
	AbM	GSIFSLNDMG	26 - 35	10
	Kabat	-----LNDMG	31 - 35	5
	Contact	----SLNDMG	30 - 35	6
	IMGT	GSIFSLND--	26 - 33	8
HFR2	Chothia	DMGWYRQAPGKLRELVAAI	33 - 51	19
	AbM	---WYRQAPGKLRELVA--	36 - 49	14
	Kabat	---WYRQAPGKLRELVA--	36 - 49	14
	Contact	---WYRQAPGKLRE-----	36 - 46	11
	IMGT	-MGWYRQAPGKLRELVAA-	34 - 50	17
CDR-H2	Chothia	-----TSGGS---------	52 - 56	5
	AbM	---AITSGGSTK-------	50 - 58	9
	Kabat	---AITSGGSTKYADSVKG	50 - 65	16
	Contact	LVAAITSGGSTK-------	47 - 58	12
	IMGT	----ITSGGST--------	51 - 57	7
HFR3	Chothia	TKYADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYCNA	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYCNA	59 - 97	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKAEDTAVYYCNA	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYC--	59 - 95	37
	IMGT	-KYADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--KVAGTFSIYDY	98 - 108	11
	AbM	--KVAGTFSIYDY	98 - 108	11
	Kabat	--KVAGTFSIYDY	98 - 108	11
	Contact	NAKVAGTFSIYD-	96 - 107	12
	IMGT	NAKVAGTFSIYDY	96 - 108	13
HFR4	Chothia	-WGQGTQVTVSS	109 - 119	11
	AbM	-WGQGTQVTVSS	109 - 119	11
	Kabat	-WGQGTQVTVSS	109 - 119	11
	Contact	YWGQGTQVTVSS	108 - 119	12
	IMGT	-WGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	5jqh_D
Source	PDB 5jqh Submitted 05-MAY-2016 Updated 20-SEP-2017
Name	STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO CARAZOLOL AND INACTIVE-STATE STABILIZING NANOBODY, NB60
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5jqh_C
References	STAUS P., STRACHAN T., MANGLIK A., PANI B., KAHSAI W., KIM H., WINGLER M., AHN S., CHATTERJEE A., MASOUDI A., KRUSE C., PARDON E., STEYAERT J., WEIS I., PROSSER S., KOBILKA K., COSTA T., LEFKOWITZ J. 'ALLOSTERIC NANOBODIES REVEAL THE DYNAMIC RANGE AND DIVERSE MECHANISMS OF G-PROTEIN-COUPLED RECEPTOR ACTIVATION.' NATURE V. 535 448 2016 ESSN 1476-4687

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGSIFSLNDMGWYRQAPGKLRELVAAITSGGSTKYA
DSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYCNAKVAGTFSIYDYWGQGTQVTVSSH
HHHHH