abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	SYVMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	AISWSGGSTNYADSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	DLASSRDVSSWY	99 - 110	12
HFR4	WGQGTQVTVSS	111 - 121	11
Tail	AAAYPYDVPDYGSHHHHHH	121 - 140	19
			140

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSSY---	26 - 32	7
	AbM	GRTFSSYVMG	26 - 35	10
	Kabat	-----SYVMG	31 - 35	5
	Contact	----SSYVMG	30 - 35	6
	IMGT	GRTFSSYV--	26 - 33	8
HFR2	Chothia	VMGWFRQAPGKEREFVAAI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----SWSGGS---------	52 - 57	6
	AbM	---AISWSGGSTN-------	50 - 59	10
	Kabat	---AISWSGGSTNYADSVKG	50 - 66	17
	Contact	FVAAISWSGGSTN-------	47 - 59	13
	IMGT	----ISWSGGST--------	51 - 58	8
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DLASSRDVSSWY	99 - 110	12
	AbM	--DLASSRDVSSWY	99 - 110	12
	Kabat	--DLASSRDVSSWY	99 - 110	12
	Contact	AADLASSRDVSSW-	97 - 109	13
	IMGT	AADLASSRDVSSWY	97 - 110	14
HFR4	Chothia	-WGQGTQVTVSS	111 - 121	11
	AbM	-WGQGTQVTVSS	111 - 121	11
	Kabat	-WGQGTQVTVSS	111 - 121	11
	Contact	YWGQGTQVTVSS	110 - 121	12
	IMGT	-WGQGTQVTVSS	111 - 121	11

Accession & Annotations

Accession	5lhr_B
Source	PDB 5lhr Submitted 12-JUL-2016 Updated 28-JUN-2017
Name	THE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ACTIVE SITE BINDING INHIBITORY NANOBODY NB22
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	KROMANN-HANSEN T., LOUISE LANGE E., PETER SRENSEN H., HASSANZADEH-GHASSABEH G., HUANG M., JENSEN K., MUYLDERMANS S., DECLERCK J., KOMIVES A., ANDREASEN A. 'DISCOVERY OF A NOVEL CONFORMATIONAL EQUILIBRIUM IN UROKINASE-TYPE PLASMINOGEN ACTIVATOR.' SCI REP V. 7 3385 2017 ESSN 2045-2322

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGRTFSSYVMGWFRQAPGKEREFVAAISWSGGSTNY
ADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAADLASSRDVSSWYWGQGTQVTVS
SAAAYPYDVPDYGSHHHHHH