abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	NDHMG	31 - 35	5
HFR2	WFRKAPGKEREFVA	36 - 49	14
CDR-H2	AITPGTEKTYYADSVKG	50 - 66	17
HFR3	RFAFSRDNAKNTVYLQMNSLKPEDTAVYYCVA	67 - 98	32
CDR-H3	TPYYRGSYYAASTYTY	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
Tail	HHHHHH	125 - 131	6
			131

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSND---	26 - 32	7
	AbM	GRTFSNDHMG	26 - 35	10
	Kabat	-----NDHMG	31 - 35	5
	Contact	----SNDHMG	30 - 35	6
	IMGT	GRTFSNDH--	26 - 33	8
HFR2	Chothia	HMGWFRKAPGKEREFVAAI	33 - 51	19
	AbM	---WFRKAPGKEREFVA--	36 - 49	14
	Kabat	---WFRKAPGKEREFVA--	36 - 49	14
	Contact	---WFRKAPGKERE-----	36 - 46	11
	IMGT	-MGWFRKAPGKEREFVAA-	34 - 50	17
CDR-H2	Chothia	-----TPGTEK---------	52 - 57	6
	AbM	---AITPGTEKTY-------	50 - 59	10
	Kabat	---AITPGTEKTYYADSVKG	50 - 66	17
	Contact	FVAAITPGTEKTY-------	47 - 59	13
	IMGT	----ITPGTEKT--------	51 - 58	8
HFR3	Chothia	TYYADSVKGRFAFSRDNAKNTVYLQMNSLKPEDTAVYYCVA	58 - 98	41
	AbM	--YADSVKGRFAFSRDNAKNTVYLQMNSLKPEDTAVYYCVA	60 - 98	39
	Kabat	---------RFAFSRDNAKNTVYLQMNSLKPEDTAVYYCVA	67 - 98	32
	Contact	--YADSVKGRFAFSRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFAFSRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--TPYYRGSYYAASTYTY	99 - 114	16
	AbM	--TPYYRGSYYAASTYTY	99 - 114	16
	Kabat	--TPYYRGSYYAASTYTY	99 - 114	16
	Contact	VATPYYRGSYYAASTYT-	97 - 113	17
	IMGT	VATPYYRGSYYAASTYTY	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	5lwf_C
Source	PDB 5lwf Submitted 16-SEP-2016 Updated 15-NOV-2017
Name	STRUCTURE OF A SINGLE DOMAIN CAMELID ANTIBODY FRAGMENT CAB-G10S IN COMPLEX WITH THE BLAP BETA-LACTAMASE FROM BACILLUS LICHENIFORMIS
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5lwf_D
References	VETTORE N., KERFF F., PAIN C., HERMAN R., SAUVAGE E., PREUMONT S., CHARLIER P., DUMOULIN M. 'PROBING THE MECHANISM OF AGGREGATION OF POLYQ MODEL PROTEINS WITH CAMELID HEAVY-CHAIN ANTIBODY FRAGMENTS' TO BE PUBLISHED

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGRTFSNDHMGWFRKAPGKEREFVAAITPGTEKTYY
ADSVKGRFAFSRDNAKNTVYLQMNSLKPEDTAVYYCVATPYYRGSYYAASTYTYWGQGTQ
VTVSSHHHHHH