abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	VQLVESGGGLVQAGGSLSLSCSASGRSLS	1 - 29	29
CDR-H1	NYYMG	30 - 34	5
HFR2	WFRQAPGKERELLG	35 - 48	14
CDR-H2	NISWRGYNIYYKDSVKG	49 - 65	17
HFR3	RFTISRDDAKNTIYLQMNRLKPEDTAVYYCAA	66 - 97	32
CDR-H3	SILPLSDDPGWNTY	98 - 111	14
HFR4	WGQGTQVTVS	112 - 121	10
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	VQLVESGGGLVQAGGSLSLSCSAS-----	1 - 24	24
	AbM	VQLVESGGGLVQAGGSLSLSCSAS-----	1 - 24	24
	Kabat	VQLVESGGGLVQAGGSLSLSCSASGRSLS	1 - 29	29
	Contact	VQLVESGGGLVQAGGSLSLSCSASGRSL-	1 - 28	28
	IMGT	VQLVESGGGLVQAGGSLSLSCSAS-----	1 - 24	24
CDR-H1	Chothia	GRSLSNY---	25 - 31	7
	AbM	GRSLSNYYMG	25 - 34	10
	Kabat	-----NYYMG	30 - 34	5
	Contact	----SNYYMG	29 - 34	6
	IMGT	GRSLSNYY--	25 - 32	8
HFR2	Chothia	YMGWFRQAPGKERELLGNI	32 - 50	19
	AbM	---WFRQAPGKERELLG--	35 - 48	14
	Kabat	---WFRQAPGKERELLG--	35 - 48	14
	Contact	---WFRQAPGKERE-----	35 - 45	11
	IMGT	-MGWFRQAPGKERELLGN-	33 - 49	17
CDR-H2	Chothia	-----SWRGYN---------	51 - 56	6
	AbM	---NISWRGYNIY-------	49 - 58	10
	Kabat	---NISWRGYNIYYKDSVKG	49 - 65	17
	Contact	LLGNISWRGYNIY-------	46 - 58	13
	IMGT	----ISWRGYNI--------	50 - 57	8
HFR3	Chothia	IYYKDSVKGRFTISRDDAKNTIYLQMNRLKPEDTAVYYCAA	57 - 97	41
	AbM	--YKDSVKGRFTISRDDAKNTIYLQMNRLKPEDTAVYYCAA	59 - 97	39
	Kabat	---------RFTISRDDAKNTIYLQMNRLKPEDTAVYYCAA	66 - 97	32
	Contact	--YKDSVKGRFTISRDDAKNTIYLQMNRLKPEDTAVYYC--	59 - 95	37
	IMGT	-YYKDSVKGRFTISRDDAKNTIYLQMNRLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--SILPLSDDPGWNTY	98 - 111	14
	AbM	--SILPLSDDPGWNTY	98 - 111	14
	Kabat	--SILPLSDDPGWNTY	98 - 111	14
	Contact	AASILPLSDDPGWNT-	96 - 110	15
	IMGT	AASILPLSDDPGWNTY	96 - 111	16
HFR4	Chothia	-WGQGTQVTVS	112 - 121	10
	AbM	-WGQGTQVTVS	112 - 121	10
	Kabat	-WGQGTQVTVS	112 - 121	10
	Contact	YWGQGTQVTVS	111 - 121	11
	IMGT	-WGQGTQVTVS	112 - 121	10

Accession & Annotations

Accession	5m2i_J
Source	PDB 5m2i Submitted 13-OCT-2016 Updated 06-SEP-2017
Name	STRUCTURE OF HUMAN TUMOR NECROSIS FACTOR (TNF) IN COMPLEX WITH THE LLAMA VHH1
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5m2i_G 5m2i_H 5m2i_I 5m2i_K 5m2i_L
References	BEIRNAERT E., DESMYTER A., SPINELLI S., LAUWEREYS M., AARDEN L., DREIER T., LORIS R., SILENCE K., POLLET C., CAMBILLAU C., DE HAARD H. 'BIVALENT LLAMA SINGLE-DOMAIN ANTIBODY FRAGMENTS AGAINST TUMOR NECROSIS FACTOR HAVE PICOMOLAR POTENCIES DUE TO INTRAMOLECULAR INTERACTIONS.' FRONT IMMUNOL V. 8 867 2017 ESSN 1664-3224

Tools

Sequences

Amino Acid Sequence:

VQLVESGGGLVQAGGSLSLSCSASGRSLSNYYMGWFRQAPGKERELLGNISWRGYNIYYK
DSVKGRFTISRDDAKNTIYLQMNRLKPEDTAVYYCAASILPLSDDPGWNTYWGQGTQVTV
S