abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
CDR-H1	DHSGYTYTIG	31 - 40	10
HFR2	WFRQAPGKEREFVA	41 - 54	14
CDR-H2	RIYWSSGNTYYADSVKG	55 - 71	17
HFR3	RFAISRDIAKNTVDLTMNNLEPEDTAVYYCAA	72 - 103	32
CDR-H3	RDGIPTSRSVESYNY	104 - 118	15
HFR4	WGQGTQVTVSS	119 - 129	11
			129

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGRTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGRTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GRTFSDHSGYTY---	26 - 37	12
	AbM	GRTFSDHSGYTYTIG	26 - 40	15
	Kabat	-----DHSGYTYTIG	31 - 40	10
	Contact	----SDHSGYTYTIG	30 - 40	11
	IMGT	GRTFSDHSGYTYT--	26 - 38	13
HFR2	Chothia	TIGWFRQAPGKEREFVARI	38 - 56	19
	AbM	---WFRQAPGKEREFVA--	41 - 54	14
	Kabat	---WFRQAPGKEREFVA--	41 - 54	14
	Contact	---WFRQAPGKERE-----	41 - 51	11
	IMGT	-IGWFRQAPGKEREFVAR-	39 - 55	17
CDR-H2	Chothia	-----YWSSGN---------	57 - 62	6
	AbM	---RIYWSSGNTY-------	55 - 64	10
	Kabat	---RIYWSSGNTYYADSVKG	55 - 71	17
	Contact	FVARIYWSSGNTY-------	52 - 64	13
	IMGT	----IYWSSGNT--------	56 - 63	8
HFR3	Chothia	TYYADSVKGRFAISRDIAKNTVDLTMNNLEPEDTAVYYCAA	63 - 103	41
	AbM	--YADSVKGRFAISRDIAKNTVDLTMNNLEPEDTAVYYCAA	65 - 103	39
	Kabat	---------RFAISRDIAKNTVDLTMNNLEPEDTAVYYCAA	72 - 103	32
	Contact	--YADSVKGRFAISRDIAKNTVDLTMNNLEPEDTAVYYC--	65 - 101	37
	IMGT	-YYADSVKGRFAISRDIAKNTVDLTMNNLEPEDTAVYYC--	64 - 101	38
CDR-H3	Chothia	--RDGIPTSRSVESYNY	104 - 118	15
	AbM	--RDGIPTSRSVESYNY	104 - 118	15
	Kabat	--RDGIPTSRSVESYNY	104 - 118	15
	Contact	AARDGIPTSRSVESYN-	102 - 117	16
	IMGT	AARDGIPTSRSVESYNY	102 - 118	17
HFR4	Chothia	-WGQGTQVTVSS	119 - 129	11
	AbM	-WGQGTQVTVSS	119 - 129	11
	Kabat	-WGQGTQVTVSS	119 - 129	11
	Contact	YWGQGTQVTVSS	118 - 129	12
	IMGT	-WGQGTQVTVSS	119 - 129	11

Accession & Annotations

Accession	5m2m_H
Source	PDB 5m2m Submitted 13-OCT-2016 Updated 06-SEP-2017
Name	COMPLEX BETWEEN HUMAN TNF ALPHA AND LLAMA VHH3
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5m2m_D 5m2m_E 5m2m_F 5m2m_J 5m2m_N
References	BEIRNAERT E., DESMYTER A., SPINELLI S., LAUWEREYS M., AARDEN L., DREIER T., LORIS R., SILENCE K., POLLET C., CAMBILLAU C., DE HAARD H. 'BIVALENT LLAMA SINGLE-DOMAIN ANTIBODY FRAGMENTS AGAINST TUMOR NECROSIS FACTOR HAVE PICOMOLAR POTENCIES DUE TO INTRAMOLECULAR INTERACTIONS.' FRONT IMMUNOL V. 8 867 2017 ESSN 1664-3224

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGRTFSDHSGYTYTIGWFRQAPGKEREFVARIYWSS
GNTYYADSVKGRFAISRDIAKNTVDLTMNNLEPEDTAVYYCAARDGIPTSRSVESYNYWG
QGTQVTVSS