abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLVESGGGLVQAGGTLKLSCAASGSISG	1 - 30	30
CDR-H1	IVVMA	31 - 35	5
HFR2	WYRQAPGKQRELVA	36 - 49	14
CDR-H2	SITSGGTTNYADSVKG	50 - 65	16
HFR3	RFTISKDNAENTLYLRMNSLKPEDTAVYYCKA	66 - 97	32
CDR-H3	FFRRDYVGYDY	98 - 108	11
HFR4	WGQGTQVTVSS	109 - 119	11
Tail	HHHHHH	119 - 125	6
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLVESGGGLVQAGGTLKLSCAAS-----	1 - 25	25
	AbM	QVQLVESGGGLVQAGGTLKLSCAAS-----	1 - 25	25
	Kabat	QVQLVESGGGLVQAGGTLKLSCAASGSISG	1 - 30	30
	Contact	QVQLVESGGGLVQAGGTLKLSCAASGSIS-	1 - 29	29
	IMGT	QVQLVESGGGLVQAGGTLKLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSISGIV---	26 - 32	7
	AbM	GSISGIVVMA	26 - 35	10
	Kabat	-----IVVMA	31 - 35	5
	Contact	----GIVVMA	30 - 35	6
	IMGT	GSISGIVV--	26 - 33	8
HFR2	Chothia	VMAWYRQAPGKQRELVASI	33 - 51	19
	AbM	---WYRQAPGKQRELVA--	36 - 49	14
	Kabat	---WYRQAPGKQRELVA--	36 - 49	14
	Contact	---WYRQAPGKQRE-----	36 - 46	11
	IMGT	-MAWYRQAPGKQRELVAS-	34 - 50	17
CDR-H2	Chothia	-----TSGGT---------	52 - 56	5
	AbM	---SITSGGTTN-------	50 - 58	9
	Kabat	---SITSGGTTNYADSVKG	50 - 65	16
	Contact	LVASITSGGTTN-------	47 - 58	12
	IMGT	----ITSGGTT--------	51 - 57	7
HFR3	Chothia	TNYADSVKGRFTISKDNAENTLYLRMNSLKPEDTAVYYCKA	57 - 97	41
	AbM	--YADSVKGRFTISKDNAENTLYLRMNSLKPEDTAVYYCKA	59 - 97	39
	Kabat	---------RFTISKDNAENTLYLRMNSLKPEDTAVYYCKA	66 - 97	32
	Contact	--YADSVKGRFTISKDNAENTLYLRMNSLKPEDTAVYYC--	59 - 95	37
	IMGT	-NYADSVKGRFTISKDNAENTLYLRMNSLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--FFRRDYVGYDY	98 - 108	11
	AbM	--FFRRDYVGYDY	98 - 108	11
	Kabat	--FFRRDYVGYDY	98 - 108	11
	Contact	KAFFRRDYVGYD-	96 - 107	12
	IMGT	KAFFRRDYVGYDY	96 - 108	13
HFR4	Chothia	-WGQGTQVTVSS	109 - 119	11
	AbM	-WGQGTQVTVSS	109 - 119	11
	Kabat	-WGQGTQVTVSS	109 - 119	11
	Contact	YWGQGTQVTVSS	108 - 119	12
	IMGT	-WGQGTQVTVSS	109 - 119	11

Accession & Annotations

Accession	5m2w_B
Source	PDB 5m2w Submitted 13-OCT-2016 Updated 30-AUG-2017
Name	STRUCTURE OF NANOBODY NB18 RAISED AGAINST TSSK FROM E. COLI T6SS
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5m2w_A 5m30_D 5m30_E 5m30_F 5mwn_D 5mwn_E 5mwn_F
References	NGUYEN S., LOGGER L., SPINELLI S., LEGRAND P., HUYEN PHAM T., NHUNG TRINH T., CHERRAK Y., ZOUED A., DESMYTER A., DURAND E., ROUSSEL A., KELLENBERGER C., CASCALES E., CAMBILLAU C. 'TYPE VI SECRETION TSSK BASEPLATE PROTEIN EXHIBITS STRUCTURAL SIMILARITY WITH PHAGE RECEPTOR-BINDING PROTEINS AND EVOLVED TO BIND THE MEMBRANE COMPLEX.' NAT MICROBIOL V. 2 17103 2017 ESSN 2058-5276

Tools

Sequences

Amino Acid Sequence:

QVQLVESGGGLVQAGGTLKLSCAASGSISGIVVMAWYRQAPGKQRELVASITSGGTTNYA
DSVKGRFTISKDNAENTLYLRMNSLKPEDTAVYYCKAFFRRDYVGYDYWGQGTQVTVSSH
HHHHH