abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQAGGSLKLTCAASGYIFN	1 - 30	30
CDR-H1	SCGMG	31 - 35	5
HFR2	WYRQSPGRERELVS	36 - 49	14
CDR-H2	RISGDGDTWHKESVKG	50 - 65	16
HFR3	RFTISQDNVKKTLYLQMNSLKPEDTAVYFCAV	66 - 97	32
CDR-H3	CYNLETY	98 - 104	7
HFR4	WGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQAGGSLKLTCAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQAGGSLKLTCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQAGGSLKLTCAASGYIFN	1 - 30	30
	Contact	QVQLQESGGGSVQAGGSLKLTCAASGYIF-	1 - 29	29
	IMGT	QVQLQESGGGSVQAGGSLKLTCAAS-----	1 - 25	25
CDR-H1	Chothia	GYIFNSC---	26 - 32	7
	AbM	GYIFNSCGMG	26 - 35	10
	Kabat	-----SCGMG	31 - 35	5
	Contact	----NSCGMG	30 - 35	6
	IMGT	GYIFNSCG--	26 - 33	8
HFR2	Chothia	GMGWYRQSPGRERELVSRI	33 - 51	19
	AbM	---WYRQSPGRERELVS--	36 - 49	14
	Kabat	---WYRQSPGRERELVS--	36 - 49	14
	Contact	---WYRQSPGRERE-----	36 - 46	11
	IMGT	-MGWYRQSPGRERELVSR-	34 - 50	17
CDR-H2	Chothia	-----SGDGD---------	52 - 56	5
	AbM	---RISGDGDTW-------	50 - 58	9
	Kabat	---RISGDGDTWHKESVKG	50 - 65	16
	Contact	LVSRISGDGDTW-------	47 - 58	12
	IMGT	----ISGDGDT--------	51 - 57	7
HFR3	Chothia	TWHKESVKGRFTISQDNVKKTLYLQMNSLKPEDTAVYFCAV	57 - 97	41
	AbM	--HKESVKGRFTISQDNVKKTLYLQMNSLKPEDTAVYFCAV	59 - 97	39
	Kabat	---------RFTISQDNVKKTLYLQMNSLKPEDTAVYFCAV	66 - 97	32
	Contact	--HKESVKGRFTISQDNVKKTLYLQMNSLKPEDTAVYFC--	59 - 95	37
	IMGT	-WHKESVKGRFTISQDNVKKTLYLQMNSLKPEDTAVYFC--	58 - 95	38
CDR-H3	Chothia	--CYNLETY	98 - 104	7
	AbM	--CYNLETY	98 - 104	7
	Kabat	--CYNLETY	98 - 104	7
	Contact	AVCYNLET-	96 - 103	8
	IMGT	AVCYNLETY	96 - 104	9
HFR4	Chothia	-WGQGTQVTVSS	105 - 115	11
	AbM	-WGQGTQVTVSS	105 - 115	11
	Kabat	-WGQGTQVTVSS	105 - 115	11
	Contact	YWGQGTQVTVSS	104 - 115	12
	IMGT	-WGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	5my6_B
Source	PDB 5my6 Submitted 25-JAN-2017 Updated 15-NOV-2017
Name	CRYSTAL STRUCTURE OF A HER2-NB COMPLEX
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	D'HUYVETTER M., DE VOS J., XAVIER C., PRUSZYNSKI M., STERCKX J., MASSA S., RAES G., CAVELIERS V., ZALUTSKY R., LAHOUTTE T., DEVOOGDT N. '(131)I-LABELED ANTI-HER2 CAMELID SDAB AS A THERANOSTIC TOOL IN CANCER TREATMENT.' CLIN. CANCER RES. V. 23 6616 2017 ISSN 1078-0432

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQAGGSLKLTCAASGYIFNSCGMGWYRQSPGRERELVSRISGDGDTWHK
ESVKGRFTISQDNVKKTLYLQMNSLKPEDTAVYFCAVCYNLETYWGQGTQVTVSS