abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MKYLLPTAAAGLLLLAAQPAMA	1 - 22	22
HFR1	EVQLVESGGGLVQAGGSLRLSCAASGRTFS	23 - 52	30
CDR-H1	WSAVG	53 - 57	5
HFR2	WFRQAPGKEREFVA	58 - 71	14
CDR-H2	AIRWSGGSPYYADSVKD	72 - 88	17
HFR3	RFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	89 - 120	32
CDR-H3	TSLFPTSRGSHYDT	121 - 134	14
HFR4	WGQGTQVTVSS	135 - 145	11
Tail	GSGWSHPQFEK	145 - 156	11
			156

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLVESGGGLVQAGGSLRLSCAAS-----	23 - 47	25
	AbM	EVQLVESGGGLVQAGGSLRLSCAAS-----	23 - 47	25
	Kabat	EVQLVESGGGLVQAGGSLRLSCAASGRTFS	23 - 52	30
	Contact	EVQLVESGGGLVQAGGSLRLSCAASGRTF-	23 - 51	29
	IMGT	EVQLVESGGGLVQAGGSLRLSCAAS-----	23 - 47	25
CDR-H1	Chothia	GRTFSWS---	48 - 54	7
	AbM	GRTFSWSAVG	48 - 57	10
	Kabat	-----WSAVG	53 - 57	5
	Contact	----SWSAVG	52 - 57	6
	IMGT	GRTFSWSA--	48 - 55	8
HFR2	Chothia	AVGWFRQAPGKEREFVAAI	55 - 73	19
	AbM	---WFRQAPGKEREFVA--	58 - 71	14
	Kabat	---WFRQAPGKEREFVA--	58 - 71	14
	Contact	---WFRQAPGKERE-----	58 - 68	11
	IMGT	-VGWFRQAPGKEREFVAA-	56 - 72	17
CDR-H2	Chothia	-----RWSGGS---------	74 - 79	6
	AbM	---AIRWSGGSPY-------	72 - 81	10
	Kabat	---AIRWSGGSPYYADSVKD	72 - 88	17
	Contact	FVAAIRWSGGSPY-------	69 - 81	13
	IMGT	----IRWSGGSP--------	73 - 80	8
HFR3	Chothia	PYYADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	80 - 120	41
	AbM	--YADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	82 - 120	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE	89 - 120	32
	Contact	--YADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLC--	82 - 118	37
	IMGT	-YYADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLC--	81 - 118	38
CDR-H3	Chothia	--TSLFPTSRGSHYDT	121 - 134	14
	AbM	--TSLFPTSRGSHYDT	121 - 134	14
	Kabat	--TSLFPTSRGSHYDT	121 - 134	14
	Contact	GETSLFPTSRGSHYD-	119 - 133	15
	IMGT	GETSLFPTSRGSHYDT	119 - 134	16
HFR4	Chothia	-WGQGTQVTVSS	135 - 145	11
	AbM	-WGQGTQVTVSS	135 - 145	11
	Kabat	-WGQGTQVTVSS	135 - 145	11
	Contact	TWGQGTQVTVSS	134 - 145	12
	IMGT	-WGQGTQVTVSS	135 - 145	11

Accession & Annotations

Accession	5mzv_D
Source	PDB 5mzv Submitted 01-FEB-2017 Updated 07-FEB-2018
Name	IL-23:IL-23R:NB22E11 COMPLEX
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	BLOCH Y., BOUCHAREYCHAS L., MERCERON R., SKLADANOWSKA K., VAN DEN BOSSCHE L., DETRY S., GOVINDARAJAN S., ELEWAUT D., HAERYNCK F., DULLAERS M., ADAMOPOULOS E., SAVVIDES N. 'STRUCTURAL ACTIVATION OF PRO-INFLAMMATORY HUMAN CYTOKINE IL-23 BY COGNATE IL-23 RECEPTOR ENABLES RECRUITMENT OF THE SHARED RECEPTOR IL-12R BETA 1.' IMMUNITY V. 48 45 2018 ISSN 1097-4180

Tools

Sequences

Amino Acid Sequence:

MKYLLPTAAAGLLLLAAQPAMAEVQLVESGGGLVQAGGSLRLSCAASGRTFSWSAVGWFR
QAPGKEREFVAAIRWSGGSPYYADSVKDRFTISRDNAKNTVYLQMNSLRPEDTAVYLCGE
TSLFPTSRGSHYDTWGQGTQVTVSSGSGWSHPQFEK

Data Source:

Alignment settings:

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