abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SYAMS	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	AITSGGGSTSYSDAVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMNSLKPEDTAVYYCAK	67 - 98	32
CDR-H3	GYVVDFLDLAEYDS	99 - 112	14
HFR4	WGQGTQVTVSS	113 - 123	11
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSY---	26 - 32	7
	AbM	GFTFSSYAMS	26 - 35	10
	Kabat	-----SYAMS	31 - 35	5
	Contact	----SSYAMS	30 - 35	6
	IMGT	GFTFSSYA--	26 - 33	8
HFR2	Chothia	AMSWVRQAPGKGLEWVSAI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MSWVRQAPGKGLEWVSA-	34 - 50	17
CDR-H2	Chothia	-----TSGGGS---------	52 - 57	6
	AbM	---AITSGGGSTS-------	50 - 59	10
	Kabat	---AITSGGGSTSYSDAVKG	50 - 66	17
	Contact	WVSAITSGGGSTS-------	47 - 59	13
	IMGT	----ITSGGGST--------	51 - 58	8
HFR3	Chothia	TSYSDAVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAK	58 - 98	41
	AbM	--YSDAVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAK	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKPEDTAVYYCAK	67 - 98	32
	Contact	--YSDAVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-SYSDAVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--GYVVDFLDLAEYDS	99 - 112	14
	AbM	--GYVVDFLDLAEYDS	99 - 112	14
	Kabat	--GYVVDFLDLAEYDS	99 - 112	14
	Contact	AKGYVVDFLDLAEYD-	97 - 111	15
	IMGT	AKGYVVDFLDLAEYDS	97 - 112	16
HFR4	Chothia	-WGQGTQVTVSS	113 - 123	11
	AbM	-WGQGTQVTVSS	113 - 123	11
	Kabat	-WGQGTQVTVSS	113 - 123	11
	Contact	SWGQGTQVTVSS	112 - 123	12
	IMGT	-WGQGTQVTVSS	113 - 123	11

Accession & Annotations

Accession	5nbd_C
Source	PDB 5nbd Submitted 01-MAR-2017 Updated 03-MAY-2017
Name	PGLK FLIPPASE IN COMPLEX WITH INHIBITORY NANOBODY
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	PEREZ C., KOHLER M., JANSER D., PARDON E., STEYAERT J., ZENOBI R., LOCHER P. 'STRUCTURAL BASIS OF INHIBITION OF LIPID-LINKED OLIGOSACCHARIDE FLIPPASE PGLK BY A CONFORMATIONAL NANOBODY.' SCI REP V. 7 46641 2017 ESSN 2045-2322

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAITSGGGSTSY
SDAVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAKGYVVDFLDLAEYDSWGQGTQVT
VSS