abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	M	1 - 1	1
HFR1	EVQLLESGGGLVQPGGSLRLSCAASGFTFG	2 - 31	30
CDR-H1	NYDMA	32 - 36	5
HFR2	WVRQAPGKRPEWVS	37 - 50	14
CDR-H2	SIDTGGDITHYADSVKG	51 - 67	17
HFR3	RFTISRDNAKNTLYLQMNSLRPEDTAVYWCAT	68 - 99	32
CDR-H3	DEEYALGPNEFDY	100 - 112	13
HFR4	YGQGTLVTVSS	113 - 123	11
Tail	AAALEHHHHHH	123 - 134	11
			134

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLLESGGGLVQPGGSLRLSCAAS-----	2 - 26	25
	AbM	EVQLLESGGGLVQPGGSLRLSCAAS-----	2 - 26	25
	Kabat	EVQLLESGGGLVQPGGSLRLSCAASGFTFG	2 - 31	30
	Contact	EVQLLESGGGLVQPGGSLRLSCAASGFTF-	2 - 30	29
	IMGT	EVQLLESGGGLVQPGGSLRLSCAAS-----	2 - 26	25
CDR-H1	Chothia	GFTFGNY---	27 - 33	7
	AbM	GFTFGNYDMA	27 - 36	10
	Kabat	-----NYDMA	32 - 36	5
	Contact	----GNYDMA	31 - 36	6
	IMGT	GFTFGNYD--	27 - 34	8
HFR2	Chothia	DMAWVRQAPGKRPEWVSSI	34 - 52	19
	AbM	---WVRQAPGKRPEWVS--	37 - 50	14
	Kabat	---WVRQAPGKRPEWVS--	37 - 50	14
	Contact	---WVRQAPGKRPE-----	37 - 47	11
	IMGT	-MAWVRQAPGKRPEWVSS-	35 - 51	17
CDR-H2	Chothia	-----DTGGDI---------	53 - 58	6
	AbM	---SIDTGGDITH-------	51 - 60	10
	Kabat	---SIDTGGDITHYADSVKG	51 - 67	17
	Contact	WVSSIDTGGDITH-------	48 - 60	13
	IMGT	----IDTGGDIT--------	52 - 59	8
HFR3	Chothia	THYADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYWCAT	59 - 99	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYWCAT	61 - 99	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLRPEDTAVYWCAT	68 - 99	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYWC--	61 - 97	37
	IMGT	-HYADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYWC--	60 - 97	38
CDR-H3	Chothia	--DEEYALGPNEFDY	100 - 112	13
	AbM	--DEEYALGPNEFDY	100 - 112	13
	Kabat	--DEEYALGPNEFDY	100 - 112	13
	Contact	ATDEEYALGPNEFD-	98 - 111	14
	IMGT	ATDEEYALGPNEFDY	98 - 112	15
HFR4	Chothia	-YGQGTLVTVSS	113 - 123	11
	AbM	-YGQGTLVTVSS	113 - 123	11
	Kabat	-YGQGTLVTVSS	113 - 123	11
	Contact	YYGQGTLVTVSS	112 - 123	12
	IMGT	-YGQGTLVTVSS	113 - 123	11

Accession & Annotations

Accession	5nqw_D
Source	PDB 5nqw Submitted 21-APR-2017 Updated 17-JAN-2018
Name	IGE-FC IN COMPLEX WITH SINGLE DOMAIN ANTIBODY 026
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5nqw_C
References	JABS F., PLUM M., LAURSEN S., JENSEN K., MOLGAARD B., MIEHE M., MANDOLESI M., RAUBER M., PFUTZNER W., JAKOB T., MOBS C., ANDERSEN R., SPILLNER E. 'TRAPPING IGE IN A CLOSED CONFORMATION BY MIMICKING CD23 BINDING PREVENTS AND DISRUPTS FC EPSILON RI INTERACTION.' NAT COMMUN V. 9 7 2018 ESSN 2041-1723

Tools

Sequences

Amino Acid Sequence:

MEVQLLESGGGLVQPGGSLRLSCAASGFTFGNYDMAWVRQAPGKRPEWVSSIDTGGDITH
YADSVKGRFTISRDNAKNTLYLQMNSLRPEDTAVYWCATDEEYALGPNEFDYYGQGTLVT
VSSAAALEHHHHHH