abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCTAPRIIFF	1 - 30	30
CDR-H1	MYDVG	31 - 35	5
HFR2	WYRQAPEKQRELVA	36 - 49	14
CDR-H2	QINSDVSTKYADSVKG	50 - 65	16
HFR3	RFTISRDNAKRTVYLQMNDLKPEDAAVYYCNV	66 - 97	32
CDR-H3	RRASADY	98 - 104	7
HFR4	WGQGTQVTVSS	105 - 115	11
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCTAP-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCTAP-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCTAPRIIFF	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCTAPRIIF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCTAP-----	1 - 25	25
CDR-H1	Chothia	RIIFFMY---	26 - 32	7
	AbM	RIIFFMYDVG	26 - 35	10
	Kabat	-----MYDVG	31 - 35	5
	Contact	----FMYDVG	30 - 35	6
	IMGT	RIIFFMYD--	26 - 33	8
HFR2	Chothia	DVGWYRQAPEKQRELVAQI	33 - 51	19
	AbM	---WYRQAPEKQRELVA--	36 - 49	14
	Kabat	---WYRQAPEKQRELVA--	36 - 49	14
	Contact	---WYRQAPEKQRE-----	36 - 46	11
	IMGT	-VGWYRQAPEKQRELVAQ-	34 - 50	17
CDR-H2	Chothia	-----NSDVS---------	52 - 56	5
	AbM	---QINSDVSTK-------	50 - 58	9
	Kabat	---QINSDVSTKYADSVKG	50 - 65	16
	Contact	LVAQINSDVSTK-------	47 - 58	12
	IMGT	----INSDVST--------	51 - 57	7
HFR3	Chothia	TKYADSVKGRFTISRDNAKRTVYLQMNDLKPEDAAVYYCNV	57 - 97	41
	AbM	--YADSVKGRFTISRDNAKRTVYLQMNDLKPEDAAVYYCNV	59 - 97	39
	Kabat	---------RFTISRDNAKRTVYLQMNDLKPEDAAVYYCNV	66 - 97	32
	Contact	--YADSVKGRFTISRDNAKRTVYLQMNDLKPEDAAVYYC--	59 - 95	37
	IMGT	-KYADSVKGRFTISRDNAKRTVYLQMNDLKPEDAAVYYC--	58 - 95	38
CDR-H3	Chothia	--RRASADY	98 - 104	7
	AbM	--RRASADY	98 - 104	7
	Kabat	--RRASADY	98 - 104	7
	Contact	NVRRASAD-	96 - 103	8
	IMGT	NVRRASADY	96 - 104	9
HFR4	Chothia	-WGQGTQVTVSS	105 - 115	11
	AbM	-WGQGTQVTVSS	105 - 115	11
	Kabat	-WGQGTQVTVSS	105 - 115	11
	Contact	YWGQGTQVTVSS	104 - 115	12
	IMGT	-WGQGTQVTVSS	105 - 115	11

Accession & Annotations

Accession	5o04_F
Source	PDB 5o04 Submitted 16-MAY-2017 Updated 28-FEB-2018
Name	GII.10 VIETNAM 026 NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO-26 AND NANO-85
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5o04_E
References	KOROMYSLOVA D., HANSMAN S. 'NANOBODIES TARGETING NOROVIRUS CAPSID REVEAL FUNCTIONAL EPITOPES AND POTENTIAL MECHANISMS OF NEUTRALIZATION.' PLOS PATHOG. V. 13 06636 2017 ESSN 1553-7374

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCTAPRIIFFMYDVGWYRQAPEKQRELVAQINSDVSTKYA
DSVKGRFTISRDNAKRTVYLQMNDLKPEDAAVYYCNVRRASADYWGQGTQVTVSS