abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGSVSR	1 - 30	30
CDR-H1	TYVMG	31 - 35	5
HFR2	WYRQTPGNQRELVA	36 - 49	14
CDR-H2	TITSVGSTNYADSLKG	50 - 65	16
HFR3	RFTISRENAENTVYLQMNSLKPEDTAIYYCKY	66 - 97	32
CDR-H3	IRYSPIHAPLDY	98 - 109	12
HFR4	WGQGTQVTVSS	110 - 120	11
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGSVSR	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGSVS-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSVSRTY---	26 - 32	7
	AbM	GSVSRTYVMG	26 - 35	10
	Kabat	-----TYVMG	31 - 35	5
	Contact	----RTYVMG	30 - 35	6
	IMGT	GSVSRTYV--	26 - 33	8
HFR2	Chothia	VMGWYRQTPGNQRELVATI	33 - 51	19
	AbM	---WYRQTPGNQRELVA--	36 - 49	14
	Kabat	---WYRQTPGNQRELVA--	36 - 49	14
	Contact	---WYRQTPGNQRE-----	36 - 46	11
	IMGT	-MGWYRQTPGNQRELVAT-	34 - 50	17
CDR-H2	Chothia	-----TSVGS---------	52 - 56	5
	AbM	---TITSVGSTN-------	50 - 58	9
	Kabat	---TITSVGSTNYADSLKG	50 - 65	16
	Contact	LVATITSVGSTN-------	47 - 58	12
	IMGT	----ITSVGST--------	51 - 57	7
HFR3	Chothia	TNYADSLKGRFTISRENAENTVYLQMNSLKPEDTAIYYCKY	57 - 97	41
	AbM	--YADSLKGRFTISRENAENTVYLQMNSLKPEDTAIYYCKY	59 - 97	39
	Kabat	---------RFTISRENAENTVYLQMNSLKPEDTAIYYCKY	66 - 97	32
	Contact	--YADSLKGRFTISRENAENTVYLQMNSLKPEDTAIYYC--	59 - 95	37
	IMGT	-NYADSLKGRFTISRENAENTVYLQMNSLKPEDTAIYYC--	58 - 95	38
CDR-H3	Chothia	--IRYSPIHAPLDY	98 - 109	12
	AbM	--IRYSPIHAPLDY	98 - 109	12
	Kabat	--IRYSPIHAPLDY	98 - 109	12
	Contact	KYIRYSPIHAPLD-	96 - 108	13
	IMGT	KYIRYSPIHAPLDY	96 - 109	14
HFR4	Chothia	-WGQGTQVTVSS	110 - 120	11
	AbM	-WGQGTQVTVSS	110 - 120	11
	Kabat	-WGQGTQVTVSS	110 - 120	11
	Contact	YWGQGTQVTVSS	109 - 120	12
	IMGT	-WGQGTQVTVSS	110 - 120	11

Accession & Annotations

Accession	5o05_D
Source	PDB 5o05 Submitted 16-MAY-2017 Updated 10-APR-2019
Name	GII.10 VIETNAM 026 NOROVIRUS PROTRUDING DOMAIN IN COMPLEX WITH NANOBODY NANO-42
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5o05_C
References	KOROMYSLOVA D., HANSMAN S. 'NANOBODIES TARGETING NOROVIRUS CAPSID REVEAL FUNCTIONAL EPITOPES AND POTENTIAL MECHANISMS OF NEUTRALIZATION.' PLOS PATHOG. V. 13 06636 2017 ESSN 1553-7374

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGSVSRTYVMGWYRQTPGNQRELVATITSVGSTNYA
DSLKGRFTISRENAENTVYLQMNSLKPEDTAIYYCKYIRYSPIHAPLDYWGQGTQVTVSS