abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	DVQLQESGGGLVQAGGSLRLSCAASGSISR	1 - 30	30
CDR-H1	FNAMG	31 - 35	5
HFR2	WWRQAPGKEREFVA	36 - 49	14
CDR-H2	RIVKGFDPVLADSVKG	50 - 65	16
HFR3	RFTISIDSAENTLALQMNRLKPEDTAVYYCFA	66 - 97	32
CDR-H3	ALDTAY	98 - 103	6
HFR4	WGQGTQVTVSS	104 - 114	11
Tail	AAADYKPGGGKPGGEPEA	114 - 132	18
			132

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	DVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	DVQLQESGGGLVQAGGSLRLSCAASGSISR	1 - 30	30
	Contact	DVQLQESGGGLVQAGGSLRLSCAASGSIS-	1 - 29	29
	IMGT	DVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GSISRFN---	26 - 32	7
	AbM	GSISRFNAMG	26 - 35	10
	Kabat	-----FNAMG	31 - 35	5
	Contact	----RFNAMG	30 - 35	6
	IMGT	GSISRFNA--	26 - 33	8
HFR2	Chothia	AMGWWRQAPGKEREFVARI	33 - 51	19
	AbM	---WWRQAPGKEREFVA--	36 - 49	14
	Kabat	---WWRQAPGKEREFVA--	36 - 49	14
	Contact	---WWRQAPGKERE-----	36 - 46	11
	IMGT	-MGWWRQAPGKEREFVAR-	34 - 50	17
CDR-H2	Chothia	-----VKGFD---------	52 - 56	5
	AbM	---RIVKGFDPV-------	50 - 58	9
	Kabat	---RIVKGFDPVLADSVKG	50 - 65	16
	Contact	FVARIVKGFDPV-------	47 - 58	12
	IMGT	----IVKGFDP--------	51 - 57	7
HFR3	Chothia	PVLADSVKGRFTISIDSAENTLALQMNRLKPEDTAVYYCFA	57 - 97	41
	AbM	--LADSVKGRFTISIDSAENTLALQMNRLKPEDTAVYYCFA	59 - 97	39
	Kabat	---------RFTISIDSAENTLALQMNRLKPEDTAVYYCFA	66 - 97	32
	Contact	--LADSVKGRFTISIDSAENTLALQMNRLKPEDTAVYYC--	59 - 95	37
	IMGT	-VLADSVKGRFTISIDSAENTLALQMNRLKPEDTAVYYC--	58 - 95	38
CDR-H3	Chothia	--ALDTAY	98 - 103	6
	AbM	--ALDTAY	98 - 103	6
	Kabat	--ALDTAY	98 - 103	6
	Contact	FAALDTA-	96 - 102	7
	IMGT	FAALDTAY	96 - 103	8
HFR4	Chothia	-WGQGTQVTVSS	104 - 114	11
	AbM	-WGQGTQVTVSS	104 - 114	11
	Kabat	-WGQGTQVTVSS	104 - 114	11
	Contact	YWGQGTQVTVSS	103 - 114	12
	IMGT	-WGQGTQVTVSS	104 - 114	11

Accession & Annotations

Accession	5o2u_B
Source	PDB 5o2u Submitted 22-MAY-2017 Updated 26-JUL-2017
Name	LLAMA VHH IN COMPLEX WITH P24
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5o2u_D
References	GRAY R., BROOKES C., CAILLAT C., TURBE V., WEBB J., GRANGER A., MILLER S., MCCOY E., EL KHATTABI M., VERRIPS T., WEISS A., DUFFY M., WEISSENHORN W., MCKENDRY A. 'UNRAVELLING THE MOLECULAR BASIS OF HIGH AFFINITY NANOBODIES AGAINST HIV P24: IN VITRO FUNCTIONAL, STRUCTURAL, AND IN SILICO INSIGHTS.' ACS INFECT DIS V. 3 479 2017 ESSN 2373-8227

Tools

Sequences

Amino Acid Sequence:

DVQLQESGGGLVQAGGSLRLSCAASGSISRFNAMGWWRQAPGKEREFVARIVKGFDPVLA
DSVKGRFTISIDSAENTLALQMNRLKPEDTAVYYCFAALDTAYWGQGTQVTVSSAAADYK
PGGGKPGGEPEA