abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQAGGSLRLSCAASGHTFN	1 - 30	30
CDR-H1	YPIMG	31 - 35	5
HFR2	WFRQAPGKEREFVG	36 - 49	14
CDR-H2	AISWSGGSTSYADSVKD	50 - 66	17
HFR3	RFTISRDNAKNTVYLEMNNLKPEDTAVYYCAA	67 - 98	32
CDR-H3	KGRYSGGLYYPTNYDY	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQAGGSLRLSCAASGHTFN	1 - 30	30
	Contact	QVQLQESGGGLVQAGGSLRLSCAASGHTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GHTFNYP---	26 - 32	7
	AbM	GHTFNYPIMG	26 - 35	10
	Kabat	-----YPIMG	31 - 35	5
	Contact	----NYPIMG	30 - 35	6
	IMGT	GHTFNYPI--	26 - 33	8
HFR2	Chothia	IMGWFRQAPGKEREFVGAI	33 - 51	19
	AbM	---WFRQAPGKEREFVG--	36 - 49	14
	Kabat	---WFRQAPGKEREFVG--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVGA-	34 - 50	17
CDR-H2	Chothia	-----SWSGGS---------	52 - 57	6
	AbM	---AISWSGGSTS-------	50 - 59	10
	Kabat	---AISWSGGSTSYADSVKD	50 - 66	17
	Contact	FVGAISWSGGSTS-------	47 - 59	13
	IMGT	----ISWSGGST--------	51 - 58	8
HFR3	Chothia	TSYADSVKDRFTISRDNAKNTVYLEMNNLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKDRFTISRDNAKNTVYLEMNNLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLEMNNLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKDRFTISRDNAKNTVYLEMNNLKPEDTAVYYC--	60 - 96	37
	IMGT	-SYADSVKDRFTISRDNAKNTVYLEMNNLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--KGRYSGGLYYPTNYDY	99 - 114	16
	AbM	--KGRYSGGLYYPTNYDY	99 - 114	16
	Kabat	--KGRYSGGLYYPTNYDY	99 - 114	16
	Contact	AAKGRYSGGLYYPTNYD-	97 - 113	17
	IMGT	AAKGRYSGGLYYPTNYDY	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	YWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	5o8f_K
Source	PDB 5o8f Submitted 13-JUN-2017 Updated 15-NOV-2017
Name	STRUCTURE OF A CHIMAERIC BETA3-ALPHA5 GABAA RECEPTOR IN COMPLEX WITH NANOBODY NB25 AND PREGNANOLONE
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5o8f_O 5ojm_K 5ojm_L 5ojm_M 5ojm_N 5ojm_O
References	MILLER S., SCOTT S., MASIULIS S., DE COLIBUS L., PARDON E., STEYAERT J., ARICESCU R. 'STRUCTURAL BASIS FOR GABAA RECEPTOR POTENTIATION BY NEUROSTEROIDS.' NAT. STRUCT. MOL. BIOL. V. 24 986 2017 ESSN 1545-9985

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQAGGSLRLSCAASGHTFNYPIMGWFRQAPGKEREFVGAISWSGGSTSY
ADSVKDRFTISRDNAKNTVYLEMNNLKPEDTAVYYCAAKGRYSGGLYYPTNYDYWGQGTQ
VTVSS