abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	GPS	1 - 3	3
HFR1	QVQLQESGGGLVQAGDSLRLSCAASGRTWS	4 - 33	30
CDR-H1	IYGMG	34 - 38	5
HFR2	WFRQAPGKEREFVA	39 - 52	14
CDR-H2	GITWRGGNTHYADFVKG	53 - 69	17
HFR3	RFTISRDNVKNTVYLQMNSLKPEDTAVYYCAA	70 - 101	32
CDR-H3	NPNPSGSSVYRRNDY	102 - 116	15
HFR4	WGQGTQVTVSS	117 - 127	11
			127

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQAGDSLRLSCAAS-----	4 - 28	25
	AbM	QVQLQESGGGLVQAGDSLRLSCAAS-----	4 - 28	25
	Kabat	QVQLQESGGGLVQAGDSLRLSCAASGRTWS	4 - 33	30
	Contact	QVQLQESGGGLVQAGDSLRLSCAASGRTW-	4 - 32	29
	IMGT	QVQLQESGGGLVQAGDSLRLSCAAS-----	4 - 28	25
CDR-H1	Chothia	GRTWSIY---	29 - 35	7
	AbM	GRTWSIYGMG	29 - 38	10
	Kabat	-----IYGMG	34 - 38	5
	Contact	----SIYGMG	33 - 38	6
	IMGT	GRTWSIYG--	29 - 36	8
HFR2	Chothia	GMGWFRQAPGKEREFVAGI	36 - 54	19
	AbM	---WFRQAPGKEREFVA--	39 - 52	14
	Kabat	---WFRQAPGKEREFVA--	39 - 52	14
	Contact	---WFRQAPGKERE-----	39 - 49	11
	IMGT	-MGWFRQAPGKEREFVAG-	37 - 53	17
CDR-H2	Chothia	-----TWRGGN---------	55 - 60	6
	AbM	---GITWRGGNTH-------	53 - 62	10
	Kabat	---GITWRGGNTHYADFVKG	53 - 69	17
	Contact	FVAGITWRGGNTH-------	50 - 62	13
	IMGT	----ITWRGGNT--------	54 - 61	8
HFR3	Chothia	THYADFVKGRFTISRDNVKNTVYLQMNSLKPEDTAVYYCAA	61 - 101	41
	AbM	--YADFVKGRFTISRDNVKNTVYLQMNSLKPEDTAVYYCAA	63 - 101	39
	Kabat	---------RFTISRDNVKNTVYLQMNSLKPEDTAVYYCAA	70 - 101	32
	Contact	--YADFVKGRFTISRDNVKNTVYLQMNSLKPEDTAVYYC--	63 - 99	37
	IMGT	-HYADFVKGRFTISRDNVKNTVYLQMNSLKPEDTAVYYC--	62 - 99	38
CDR-H3	Chothia	--NPNPSGSSVYRRNDY	102 - 116	15
	AbM	--NPNPSGSSVYRRNDY	102 - 116	15
	Kabat	--NPNPSGSSVYRRNDY	102 - 116	15
	Contact	AANPNPSGSSVYRRND-	100 - 115	16
	IMGT	AANPNPSGSSVYRRNDY	100 - 116	17
HFR4	Chothia	-WGQGTQVTVSS	117 - 127	11
	AbM	-WGQGTQVTVSS	117 - 127	11
	Kabat	-WGQGTQVTVSS	117 - 127	11
	Contact	YWGQGTQVTVSS	116 - 127	12
	IMGT	-WGQGTQVTVSS	117 - 127	11

Accession & Annotations

Accession	5ocl_E
Source	PDB 5ocl Submitted 03-JUL-2017 Updated 09-AUG-2017
Name	NANOBODY-ANTI-VGLUT NANOBODY COMPLEX
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5ocl_B 5ocl_D 5ocl_G
References	SCHENCK S., KUNZ L., SAHLENDER D., PARDON E., GEERTSMA R., SAVTCHOUK I., SUZUKI T., NELDNER Y., STEFANIC S., STEYAERT J., VOLTERRA A., DUTZLER R. 'GENERATION AND CHARACTERIZATION OF ANTI-VGLUT NANOBODIES ACTING AS INHIBITORS OF TRANSPORT.' BIOCHEMISTRY V. 56 3962 2017 ISSN 1520-4995

Tools

Sequences

Amino Acid Sequence:

GPSQVQLQESGGGLVQAGDSLRLSCAASGRTWSIYGMGWFRQAPGKEREFVAGITWRGGN
THYADFVKGRFTISRDNVKNTVYLQMNSLKPEDTAVYYCAANPNPSGSSVYRRNDYWGQG
TQVTVSS