abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	GPS	1 - 3	3
HFR1	QGQLVESGGGLVQAGGSLRLSCAASGIIFR	4 - 33	30
CDR-H1	ELGID	34 - 38	5
HFR2	WYRQAPGKQRELVA	39 - 52	14
CDR-H2	SIASAGMTNYADSVKG	53 - 68	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCHT	69 - 100	32
CDR-H3	LPRFSHL	101 - 107	7
HFR4	WGQGTRVTVSS	108 - 118	11
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QGQLVESGGGLVQAGGSLRLSCAAS-----	4 - 28	25
	AbM	QGQLVESGGGLVQAGGSLRLSCAAS-----	4 - 28	25
	Kabat	QGQLVESGGGLVQAGGSLRLSCAASGIIFR	4 - 33	30
	Contact	QGQLVESGGGLVQAGGSLRLSCAASGIIF-	4 - 32	29
	IMGT	QGQLVESGGGLVQAGGSLRLSCAAS-----	4 - 28	25
CDR-H1	Chothia	GIIFREL---	29 - 35	7
	AbM	GIIFRELGID	29 - 38	10
	Kabat	-----ELGID	34 - 38	5
	Contact	----RELGID	33 - 38	6
	IMGT	GIIFRELG--	29 - 36	8
HFR2	Chothia	GIDWYRQAPGKQRELVASI	36 - 54	19
	AbM	---WYRQAPGKQRELVA--	39 - 52	14
	Kabat	---WYRQAPGKQRELVA--	39 - 52	14
	Contact	---WYRQAPGKQRE-----	39 - 49	11
	IMGT	-IDWYRQAPGKQRELVAS-	37 - 53	17
CDR-H2	Chothia	-----ASAGM---------	55 - 59	5
	AbM	---SIASAGMTN-------	53 - 61	9
	Kabat	---SIASAGMTNYADSVKG	53 - 68	16
	Contact	LVASIASAGMTN-------	50 - 61	12
	IMGT	----IASAGMT--------	54 - 60	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHT	60 - 100	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHT	62 - 100	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCHT	69 - 100	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	62 - 98	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	61 - 98	38
CDR-H3	Chothia	--LPRFSHL	101 - 107	7
	AbM	--LPRFSHL	101 - 107	7
	Kabat	--LPRFSHL	101 - 107	7
	Contact	HTLPRFSH-	99 - 106	8
	IMGT	HTLPRFSHL	99 - 107	9
HFR4	Chothia	-WGQGTRVTVSS	108 - 118	11
	AbM	-WGQGTRVTVSS	108 - 118	11
	Kabat	-WGQGTRVTVSS	108 - 118	11
	Contact	LWGQGTRVTVSS	107 - 118	12
	IMGT	-WGQGTRVTVSS	108 - 118	11

Accession & Annotations

Accession	5ocl_F
Source	PDB 5ocl Submitted 03-JUL-2017 Updated 09-AUG-2017
Name	NANOBODY-ANTI-VGLUT NANOBODY COMPLEX
Organism	Vicugna pacos
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5ocl_A 5ocl_C 5ocl_H
References	SCHENCK S., KUNZ L., SAHLENDER D., PARDON E., GEERTSMA R., SAVTCHOUK I., SUZUKI T., NELDNER Y., STEFANIC S., STEYAERT J., VOLTERRA A., DUTZLER R. 'GENERATION AND CHARACTERIZATION OF ANTI-VGLUT NANOBODIES ACTING AS INHIBITORS OF TRANSPORT.' BIOCHEMISTRY V. 56 3962 2017 ISSN 1520-4995

Tools

Sequences

Amino Acid Sequence:

GPSQGQLVESGGGLVQAGGSLRLSCAASGIIFRELGIDWYRQAPGKQRELVASIASAGMT
NYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCHTLPRFSHLWGQGTRVTVSS