abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SYGMS	31 - 35	5
HFR2	WVRQAPGKGLAWVS	36 - 49	14
CDR-H2	TIDSGGGDRYYTDSVKG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQLNSLKTEDTAMYYCAK	67 - 98	32
CDR-H3	LPGGGPELRLRDIATMP	99 - 115	17
HFR4	KGQGTLVTVSS	116 - 126	11
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSY---	26 - 32	7
	AbM	GFTFSSYGMS	26 - 35	10
	Kabat	-----SYGMS	31 - 35	5
	Contact	----SSYGMS	30 - 35	6
	IMGT	GFTFSSYG--	26 - 33	8
HFR2	Chothia	GMSWVRQAPGKGLAWVSTI	33 - 51	19
	AbM	---WVRQAPGKGLAWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLAWVS--	36 - 49	14
	Contact	---WVRQAPGKGLA-----	36 - 46	11
	IMGT	-MSWVRQAPGKGLAWVST-	34 - 50	17
CDR-H2	Chothia	-----DSGGGD---------	52 - 57	6
	AbM	---TIDSGGGDRY-------	50 - 59	10
	Kabat	---TIDSGGGDRYYTDSVKG	50 - 66	17
	Contact	WVSTIDSGGGDRY-------	47 - 59	13
	IMGT	----IDSGGGDR--------	51 - 58	8
HFR3	Chothia	RYYTDSVKGRFTISRDNAKNTLYLQLNSLKTEDTAMYYCAK	58 - 98	41
	AbM	--YTDSVKGRFTISRDNAKNTLYLQLNSLKTEDTAMYYCAK	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQLNSLKTEDTAMYYCAK	67 - 98	32
	Contact	--YTDSVKGRFTISRDNAKNTLYLQLNSLKTEDTAMYYC--	60 - 96	37
	IMGT	-YYTDSVKGRFTISRDNAKNTLYLQLNSLKTEDTAMYYC--	59 - 96	38
CDR-H3	Chothia	--LPGGGPELRLRDIATMP	99 - 115	17
	AbM	--LPGGGPELRLRDIATMP	99 - 115	17
	Kabat	--LPGGGPELRLRDIATMP	99 - 115	17
	Contact	AKLPGGGPELRLRDIATM-	97 - 114	18
	IMGT	AKLPGGGPELRLRDIATMP	97 - 115	19
HFR4	Chothia	-KGQGTLVTVSS	116 - 126	11
	AbM	-KGQGTLVTVSS	116 - 126	11
	Kabat	-KGQGTLVTVSS	116 - 126	11
	Contact	PKGQGTLVTVSS	115 - 126	12
	IMGT	-KGQGTLVTVSS	116 - 126	11

Accession & Annotations

Accession	BAQ56200.1
Source	abYsis-EMBL-IG AB987660 Submitted 14-MAR-2015 Updated 14-MAR-2015
Name	immunoglobulin heavy chain variable region
Clone	3-DR5
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Jalili S., Hasannia S., Shahangian S.S., Arab S.S., Momendizghandi H., Mohammadi M., Hasansajedi R., Khajeh K., Shali A., Mirshahi M. Submitted (02-SEP-2014) to the INSDC. Contact:Shirin Jalili Tarbiat Modares University, Biochemistry; Jalal Ale Ahmad Highway, P.O.Box, Tehran 14115-111, Iran Jalili S., Hasannia S., Shahangian S.S., Arab S.S., Momendizghandi H., Mohammadi M., Hasansajedi R., Khajeh K., Shali A., Mirshahi M. 'Construction and screening of camels nanobodies against death receptor 5 using phage display to induce apoptosis in cancer cells' Unpublished.

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKGLAWVSTIDSGGGDRYY
TDSVKGRFTISRDNAKNTLYLQLNSLKTEDTAMYYCAKLPGGGPELRLRDIATMPKGQGT
LVTVSS

DNA Sequence:

caggtgcagctgcaggagtcggggggaggcttggtgcagcccggggggtctctgagactc
tcctgtgcagcttctggattcaccttcagtagctatggcatgagctgggtccgccaggct
ccagggaaggggctcgcctgggtctcaacaattgatagtggtggtggtgacagatactat
acagactccgtgaagggccgattcaccatctccagagacaacgccaagaacacgctgtat
ctgcaattgaatagcctgaaaactgaggacacggccatgtattactgtgcaaagcttccg
ggcggtgggccggaacttcgtctacgtgacatagcgactatgcctaagggccaggggacc
ctggtcaccgtctcctca

Data Source:

Alignment settings:

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