abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGSVQAGGSLRLSCAASGYIYS	1 - 30	30
CDR-H1	NYCMA	31 - 35	5
HFR2	WFRQAPGKEREGVA	36 - 49	14
CDR-H2	HIKGRDDRTIYAASLQG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNNLKPEDTAIYYCAA	67 - 98	32
CDR-H3	DTSPLCGPATWRNINGYDY	99 - 117	19
HFR4	WGQGTQVTVSS	118 - 128	11
			128

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGSVQAGGSLRLSCAASGYIYS	1 - 30	30
	Contact	QVQLQESGGGSVQAGGSLRLSCAASGYIY-	1 - 29	29
	IMGT	QVQLQESGGGSVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GYIYSNY---	26 - 32	7
	AbM	GYIYSNYCMA	26 - 35	10
	Kabat	-----NYCMA	31 - 35	5
	Contact	----SNYCMA	30 - 35	6
	IMGT	GYIYSNYC--	26 - 33	8
HFR2	Chothia	CMAWFRQAPGKEREGVAHI	33 - 51	19
	AbM	---WFRQAPGKEREGVA--	36 - 49	14
	Kabat	---WFRQAPGKEREGVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MAWFRQAPGKEREGVAH-	34 - 50	17
CDR-H2	Chothia	-----KGRDDR---------	52 - 57	6
	AbM	---HIKGRDDRTI-------	50 - 59	10
	Kabat	---HIKGRDDRTIYAASLQG	50 - 66	17
	Contact	GVAHIKGRDDRTI-------	47 - 59	13
	IMGT	----IKGRDDRT--------	51 - 58	8
HFR3	Chothia	TIYAASLQGRFTISRDNAKNTVYLQMNNLKPEDTAIYYCAA	58 - 98	41
	AbM	--YAASLQGRFTISRDNAKNTVYLQMNNLKPEDTAIYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNNLKPEDTAIYYCAA	67 - 98	32
	Contact	--YAASLQGRFTISRDNAKNTVYLQMNNLKPEDTAIYYC--	60 - 96	37
	IMGT	-IYAASLQGRFTISRDNAKNTVYLQMNNLKPEDTAIYYC--	59 - 96	38
CDR-H3	Chothia	--DTSPLCGPATWRNINGYDY	99 - 117	19
	AbM	--DTSPLCGPATWRNINGYDY	99 - 117	19
	Kabat	--DTSPLCGPATWRNINGYDY	99 - 117	19
	Contact	AADTSPLCGPATWRNINGYD-	97 - 116	20
	IMGT	AADTSPLCGPATWRNINGYDY	97 - 117	21
HFR4	Chothia	-WGQGTQVTVSS	118 - 128	11
	AbM	-WGQGTQVTVSS	118 - 128	11
	Kabat	-WGQGTQVTVSS	118 - 128	11
	Contact	YWGQGTQVTVSS	117 - 128	12
	IMGT	-WGQGTQVTVSS	118 - 128	11

Accession & Annotations

Accession	BAQ56201.1
Source	abYsis-EMBL-IG AB987661 Submitted 14-MAR-2015 Updated 14-MAR-2015
Name	immunoglobulin heavy chain variable region
Clone	4-DR5
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Jalili S., Hasannia S., Shahangian S.S., Arab S.S., Momendizghandi H., Mohammadi M., Hasansajedi R., Khajeh K., Shali A., Mirshahi M. Submitted (02-SEP-2014) to the INSDC. Contact:Shirin Jalili Tarbiat Modares University, Biochemistry; Jalal Ale Ahmad Highway, P.O.Box, Tehran 14115-111, Iran Jalili S., Hasannia S., Shahangian S.S., Arab S.S., Momendizghandi H., Mohammadi M., Hasansajedi R., Khajeh K., Shali A., Mirshahi M. 'Construction and screening of camels nanobodies against death receptor 5 using phage display to induce apoptosis in cancer cells' Unpublished.

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGSVQAGGSLRLSCAASGYIYSNYCMAWFRQAPGKEREGVAHIKGRDDRTIY
AASLQGRFTISRDNAKNTVYLQMNNLKPEDTAIYYCAADTSPLCGPATWRNINGYDYWGQ
GTQVTVSS

DNA Sequence:

caggtgcagctgcaggagtcggggggaggctcggtgcaggctggagggtctctgagactc
tcctgtgcagcctctggatacatctacagtaactactgcatggcctggttccgccaggct
ccagggaaggagcgtgagggggtcgcgcatattaaaggtcgtgatgataggacaatatac
gccgcctccctgcagggccgattcaccatctcccgagacaacgccaagaacacggtgtat
ctgcaaatgaacaacctgaaacctgaggacacggccatctattactgtgcggcagatact
tctcccctgtgtgggcctgctacctggcggaacataaatgggtatgattactggggccag
gggacccaggtcaccgtctcctca

Data Source:

Alignment settings:

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