abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
CDR-H1	SYSMN	31 - 35	5
HFR2	WVRQAPGKGLEWVS	36 - 49	14
CDR-H2	GIGAAGTYTYYADSLEG	50 - 66	17
HFR3	RFTISRDNAKNTLYLQMNSLKSEDTARYYCAR	67 - 98	32
CDR-H3	GVPRCTDNCAY	99 - 109	11
HFR4	RGQGTLVTVSS	110 - 120	11
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	AbM	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
	Kabat	QVQLQESGGGLVQPGGSLRLSCAASGFTFS	1 - 30	30
	Contact	QVQLQESGGGLVQPGGSLRLSCAASGFTF-	1 - 29	29
	IMGT	QVQLQESGGGLVQPGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFTFSSY---	26 - 32	7
	AbM	GFTFSSYSMN	26 - 35	10
	Kabat	-----SYSMN	31 - 35	5
	Contact	----SSYSMN	30 - 35	6
	IMGT	GFTFSSYS--	26 - 33	8
HFR2	Chothia	SMNWVRQAPGKGLEWVSGI	33 - 51	19
	AbM	---WVRQAPGKGLEWVS--	36 - 49	14
	Kabat	---WVRQAPGKGLEWVS--	36 - 49	14
	Contact	---WVRQAPGKGLE-----	36 - 46	11
	IMGT	-MNWVRQAPGKGLEWVSG-	34 - 50	17
CDR-H2	Chothia	-----GAAGTY---------	52 - 57	6
	AbM	---GIGAAGTYTY-------	50 - 59	10
	Kabat	---GIGAAGTYTYYADSLEG	50 - 66	17
	Contact	WVSGIGAAGTYTY-------	47 - 59	13
	IMGT	----IGAAGTYT--------	51 - 58	8
HFR3	Chothia	TYYADSLEGRFTISRDNAKNTLYLQMNSLKSEDTARYYCAR	58 - 98	41
	AbM	--YADSLEGRFTISRDNAKNTLYLQMNSLKSEDTARYYCAR	60 - 98	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKSEDTARYYCAR	67 - 98	32
	Contact	--YADSLEGRFTISRDNAKNTLYLQMNSLKSEDTARYYC--	60 - 96	37
	IMGT	-YYADSLEGRFTISRDNAKNTLYLQMNSLKSEDTARYYC--	59 - 96	38
CDR-H3	Chothia	--GVPRCTDNCAY	99 - 109	11
	AbM	--GVPRCTDNCAY	99 - 109	11
	Kabat	--GVPRCTDNCAY	99 - 109	11
	Contact	ARGVPRCTDNCA-	97 - 108	12
	IMGT	ARGVPRCTDNCAY	97 - 109	13
HFR4	Chothia	-RGQGTLVTVSS	110 - 120	11
	AbM	-RGQGTLVTVSS	110 - 120	11
	Kabat	-RGQGTLVTVSS	110 - 120	11
	Contact	YRGQGTLVTVSS	109 - 120	12
	IMGT	-RGQGTLVTVSS	110 - 120	11

Accession & Annotations

Accession	BAQ56202.1
Source	abYsis-EMBL-IG AB987662 Submitted 14-MAR-2015 Updated 14-MAR-2015
Name	immunoglobulin heavy chain variable region
Clone	6-DR5
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Jalili S., Hasannia S., Shahangian S.S., Arab S.S., Momendizghandi H., Mohammadi M., Hasansajedi R., Khajeh K., Shali A., Mirshahi M. Submitted (02-SEP-2014) to the INSDC. Contact:Shirin Jalili Tarbiat Modares University, Biochemistry; Jalal Ale Ahmad Highway, P.O.Box, Tehran 14115-111, Iran Jalili S., Hasannia S., Shahangian S.S., Arab S.S., Momendizghandi H., Mohammadi M., Hasansajedi R., Khajeh K., Shali A., Mirshahi M. 'Construction and screening of camels nanobodies against death receptor 5 using phage display to induce apoptosis in cancer cells' Unpublished.

Tools

Sequences

Amino Acid Sequence:

QVQLQESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSGIGAAGTYTYY
ADSLEGRFTISRDNAKNTLYLQMNSLKSEDTARYYCARGVPRCTDNCAYRGQGTLVTVSS

DNA Sequence:

caggtgcagctgcaggagtcggggggaggcttggtgcagcctggggggtctctgagactc
tcctgtgcagcctcaggattcaccttcagtagctattccatgaactgggtccggcaggct
ccagggaaggggctggagtgggtgtccggtattggtgccgccggtacatacacatactat
gcagactccctagagggccgattcaccatctccagagacaacgccaagaacacactatat
ctgcagatgaacagcctaaaatctgaagacacggcccgttattactgtgcccgtggtgtg
ccgcgttgtactgacaactgcgcctacaggggccaggggaccctggtcaccgtctcctca

Data Source:

Alignment settings:

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