abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MKYLLPTAAAGLLLLAAQPAMA	1 - 22	22
HFR1	QMQLVESGGGLVQPGGSLRLSCAAPESTLD	23 - 52	30
CDR-H1	DYAIG	53 - 57	5
HFR2	WFRQAPGKEREGVS	58 - 71	14
CDR-H2	CIGSSGDSTNYADSVKG	72 - 88	17
HFR3	RFTVSRDNAKNTVYLQMNDLRPEDTAVYYCAA	89 - 120	32
CDR-H3	AHRIFGGCLVIHSSGYVS	121 - 138	18
HFR4	WGQGTPVTVSS	139 - 149	11
Tail	HHHHHHEPEA	149 - 159	10
			159

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	QMQLVESGGGLVQPGGSLRLSCAAP-----	23 - 47	25
	AbM	QMQLVESGGGLVQPGGSLRLSCAAP-----	23 - 47	25
	Kabat	QMQLVESGGGLVQPGGSLRLSCAAPESTLD	23 - 52	30
	Contact	QMQLVESGGGLVQPGGSLRLSCAAPESTL-	23 - 51	29
	IMGT	QMQLVESGGGLVQPGGSLRLSCAAP-----	23 - 47	25
CDR-H1	Chothia	ESTLDDY---	48 - 54	7
	AbM	ESTLDDYAIG	48 - 57	10
	Kabat	-----DYAIG	53 - 57	5
	Contact	----DDYAIG	52 - 57	6
	IMGT	ESTLDDYA--	48 - 55	8
HFR2	Chothia	AIGWFRQAPGKEREGVSCI	55 - 73	19
	AbM	---WFRQAPGKEREGVS--	58 - 71	14
	Kabat	---WFRQAPGKEREGVS--	58 - 71	14
	Contact	---WFRQAPGKERE-----	58 - 68	11
	IMGT	-IGWFRQAPGKEREGVSC-	56 - 72	17
CDR-H2	Chothia	-----GSSGDS---------	74 - 79	6
	AbM	---CIGSSGDSTN-------	72 - 81	10
	Kabat	---CIGSSGDSTNYADSVKG	72 - 88	17
	Contact	GVSCIGSSGDSTN-------	69 - 81	13
	IMGT	----IGSSGDST--------	73 - 80	8
HFR3	Chothia	TNYADSVKGRFTVSRDNAKNTVYLQMNDLRPEDTAVYYCAA	80 - 120	41
	AbM	--YADSVKGRFTVSRDNAKNTVYLQMNDLRPEDTAVYYCAA	82 - 120	39
	Kabat	---------RFTVSRDNAKNTVYLQMNDLRPEDTAVYYCAA	89 - 120	32
	Contact	--YADSVKGRFTVSRDNAKNTVYLQMNDLRPEDTAVYYC--	82 - 118	37
	IMGT	-NYADSVKGRFTVSRDNAKNTVYLQMNDLRPEDTAVYYC--	81 - 118	38
CDR-H3	Chothia	--AHRIFGGCLVIHSSGYVS	121 - 138	18
	AbM	--AHRIFGGCLVIHSSGYVS	121 - 138	18
	Kabat	--AHRIFGGCLVIHSSGYVS	121 - 138	18
	Contact	AAAHRIFGGCLVIHSSGYV-	119 - 137	19
	IMGT	AAAHRIFGGCLVIHSSGYVS	119 - 138	20
HFR4	Chothia	-WGQGTPVTVSS	139 - 149	11
	AbM	-WGQGTPVTVSS	139 - 149	11
	Kabat	-WGQGTPVTVSS	139 - 149	11
	Contact	SWGQGTPVTVSS	138 - 149	12
	IMGT	-WGQGTPVTVSS	139 - 149	11

Accession & Annotations

Accession	5ovw_J
Source	PDB 5ovw Submitted 30-AUG-2017 Updated 08-NOV-2017
Name	NANOBODY-BOUND BTUF, THE VITAMIN B12 BINDING PROTEIN IN ESCHERICHIA COLI
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	PDB: 5ovw_G 5ovw_H 5ovw_I 5ovw_K 5ovw_L
References	MIREKU A., SAUER M., GLOCKSHUBER R., LOCHER P. 'STRUCTURAL BASIS OF NANOBODY-MEDIATED BLOCKING OF BTUF, THE COGNATE SUBSTRATE-BINDING PROTEIN OF THE ESCHERICHIA COLI VITAMIN B12 TRANSPORTER BTUCD.' SCI REP V. 7 14296 2017 ESSN 2045-2322

Tools

Sequences

Amino Acid Sequence:

MKYLLPTAAAGLLLLAAQPAMAQMQLVESGGGLVQPGGSLRLSCAAPESTLDDYAIGWFR
QAPGKEREGVSCIGSSGDSTNYADSVKGRFTVSRDNAKNTVYLQMNDLRPEDTAVYYCAA
AHRIFGGCLVIHSSGYVSWGQGTPVTVSSHHHHHHEPEA

Data Source:

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