abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLQASGGGLVQAGGSLRLSCAASGFKIT	1 - 30	30
CDR-H1	HYTMG	31 - 35	5
HFR2	WFRQAPGKEREFVS	36 - 49	14
CDR-H2	RITWGGDNTFYSNSVKG	50 - 66	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTADYYCAA	67 - 98	32
CDR-H3	GSTSTATPLRVDY	99 - 111	13
HFR4	WGKGTQVTVSS	112 - 122	11
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	AbM	EVQLQASGGGLVQAGGSLRLSCAAS-----	1 - 25	25
	Kabat	EVQLQASGGGLVQAGGSLRLSCAASGFKIT	1 - 30	30
	Contact	EVQLQASGGGLVQAGGSLRLSCAASGFKI-	1 - 29	29
	IMGT	EVQLQASGGGLVQAGGSLRLSCAAS-----	1 - 25	25
CDR-H1	Chothia	GFKITHY---	26 - 32	7
	AbM	GFKITHYTMG	26 - 35	10
	Kabat	-----HYTMG	31 - 35	5
	Contact	----THYTMG	30 - 35	6
	IMGT	GFKITHYT--	26 - 33	8
HFR2	Chothia	TMGWFRQAPGKEREFVSRI	33 - 51	19
	AbM	---WFRQAPGKEREFVS--	36 - 49	14
	Kabat	---WFRQAPGKEREFVS--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVSR-	34 - 50	17
CDR-H2	Chothia	-----TWGGDN---------	52 - 57	6
	AbM	---RITWGGDNTF-------	50 - 59	10
	Kabat	---RITWGGDNTFYSNSVKG	50 - 66	17
	Contact	FVSRITWGGDNTF-------	47 - 59	13
	IMGT	----ITWGGDNT--------	51 - 58	8
HFR3	Chothia	TFYSNSVKGRFTISRDNAKNTVYLQMNSLKPEDTADYYCAA	58 - 98	41
	AbM	--YSNSVKGRFTISRDNAKNTVYLQMNSLKPEDTADYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTADYYCAA	67 - 98	32
	Contact	--YSNSVKGRFTISRDNAKNTVYLQMNSLKPEDTADYYC--	60 - 96	37
	IMGT	-FYSNSVKGRFTISRDNAKNTVYLQMNSLKPEDTADYYC--	59 - 96	38
CDR-H3	Chothia	--GSTSTATPLRVDY	99 - 111	13
	AbM	--GSTSTATPLRVDY	99 - 111	13
	Kabat	--GSTSTATPLRVDY	99 - 111	13
	Contact	AAGSTSTATPLRVD-	97 - 110	14
	IMGT	AAGSTSTATPLRVDY	97 - 111	15
HFR4	Chothia	-WGKGTQVTVSS	112 - 122	11
	AbM	-WGKGTQVTVSS	112 - 122	11
	Kabat	-WGKGTQVTVSS	112 - 122	11
	Contact	YWGKGTQVTVSS	111 - 122	12
	IMGT	-WGKGTQVTVSS	112 - 122	11

Accession & Annotations

Accession	AAL58846.1
Source	abYsis-EMBL-IG AF441486 Submitted 08-JAN-2002 Updated 11-APR-2002
Name	immunoglobulin heavy chain variable domain FC5
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tanha J., Muruganandam A. Submitted (30-OCT-2001) to the INSDC. National Research Council of Canada, Institute for Biological Sciences, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada Muruganandam A., Tanha J., Narang S., Stanimirovic D. 'Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium' FASEB J. 16(2):240-242(2002).

Tools

Sequences

Amino Acid Sequence:

EVQLQASGGGLVQAGGSLRLSCAASGFKITHYTMGWFRQAPGKEREFVSRITWGGDNTFY
SNSVKGRFTISRDNAKNTVYLQMNSLKPEDTADYYCAAGSTSTATPLRVDYWGKGTQVTV
SS

DNA Sequence:

gaggtccagctgcaggcgtctggaggaggattggtgcaggctgggggctctctgagactc
tcctgtgcagcctctggattcaaaatcactcactataccatgggctggttccgccaggct
ccagggaaggagcgtgaatttgtatcacgtattacttggggtggtgataacaccttctat
tcaaactccgtgaagggccgattcaccatttccagagacaacgccaagaacacggtctat
ctgcaaatgaacagcctgaaacctgaggacacggccgattattactgtgcagcaggttcg
acgtcgactgcgacgccacttagggtggactactggggcaaagggacccaggtcaccgtc
tcctca

Data Source:

Alignment settings:

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