abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	EVQLQASGGGLVQAGGSLRLSCSASVRTFS	1 - 30	30
CDR-H1	IYAMG	31 - 35	5
HFR2	WFRQAPGKEREFVA	36 - 49	14
CDR-H2	GINRSGDVTKYADFVKG	50 - 66	17
HFR3	RFSISRDNAKNMVYLQMNSLKPEDTALYYCAA	67 - 98	32
CDR-H3	TWAYDTVGALTSGYNF	99 - 114	16
HFR4	WGQGTQVTVSS	115 - 125	11
			125

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	EVQLQASGGGLVQAGGSLRLSCSAS-----	1 - 25	25
	AbM	EVQLQASGGGLVQAGGSLRLSCSAS-----	1 - 25	25
	Kabat	EVQLQASGGGLVQAGGSLRLSCSASVRTFS	1 - 30	30
	Contact	EVQLQASGGGLVQAGGSLRLSCSASVRTF-	1 - 29	29
	IMGT	EVQLQASGGGLVQAGGSLRLSCSAS-----	1 - 25	25
CDR-H1	Chothia	VRTFSIY---	26 - 32	7
	AbM	VRTFSIYAMG	26 - 35	10
	Kabat	-----IYAMG	31 - 35	5
	Contact	----SIYAMG	30 - 35	6
	IMGT	VRTFSIYA--	26 - 33	8
HFR2	Chothia	AMGWFRQAPGKEREFVAGI	33 - 51	19
	AbM	---WFRQAPGKEREFVA--	36 - 49	14
	Kabat	---WFRQAPGKEREFVA--	36 - 49	14
	Contact	---WFRQAPGKERE-----	36 - 46	11
	IMGT	-MGWFRQAPGKEREFVAG-	34 - 50	17
CDR-H2	Chothia	-----NRSGDV---------	52 - 57	6
	AbM	---GINRSGDVTK-------	50 - 59	10
	Kabat	---GINRSGDVTKYADFVKG	50 - 66	17
	Contact	FVAGINRSGDVTK-------	47 - 59	13
	IMGT	----INRSGDVT--------	51 - 58	8
HFR3	Chothia	TKYADFVKGRFSISRDNAKNMVYLQMNSLKPEDTALYYCAA	58 - 98	41
	AbM	--YADFVKGRFSISRDNAKNMVYLQMNSLKPEDTALYYCAA	60 - 98	39
	Kabat	---------RFSISRDNAKNMVYLQMNSLKPEDTALYYCAA	67 - 98	32
	Contact	--YADFVKGRFSISRDNAKNMVYLQMNSLKPEDTALYYC--	60 - 96	37
	IMGT	-KYADFVKGRFSISRDNAKNMVYLQMNSLKPEDTALYYC--	59 - 96	38
CDR-H3	Chothia	--TWAYDTVGALTSGYNF	99 - 114	16
	AbM	--TWAYDTVGALTSGYNF	99 - 114	16
	Kabat	--TWAYDTVGALTSGYNF	99 - 114	16
	Contact	AATWAYDTVGALTSGYN-	97 - 113	17
	IMGT	AATWAYDTVGALTSGYNF	97 - 114	18
HFR4	Chothia	-WGQGTQVTVSS	115 - 125	11
	AbM	-WGQGTQVTVSS	115 - 125	11
	Kabat	-WGQGTQVTVSS	115 - 125	11
	Contact	FWGQGTQVTVSS	114 - 125	12
	IMGT	-WGQGTQVTVSS	115 - 125	11

Accession & Annotations

Accession	AAL58847.1
Source	abYsis-EMBL-IG AF441487 Submitted 08-JAN-2002 Updated 11-APR-2002
Name	immunoglobulin heavy chain variable domain FC44
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Tanha J., Muruganandam A. Submitted (30-OCT-2001) to the INSDC. National Research Council of Canada, Institute for Biological Sciences, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada Muruganandam A., Tanha J., Narang S., Stanimirovic D. 'Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium' FASEB J. 16(2):240-242(2002).

Tools

Sequences

Amino Acid Sequence:

EVQLQASGGGLVQAGGSLRLSCSASVRTFSIYAMGWFRQAPGKEREFVAGINRSGDVTKY
ADFVKGRFSISRDNAKNMVYLQMNSLKPEDTALYYCAATWAYDTVGALTSGYNFWGQGTQ
VTVSS

DNA Sequence:

gaggtgcagctgcaggcgtctgggggaggattggtgcaggctgggggctctctgagactc
tcctgttcagcctctgtacgcaccttcagtatatatgccatgggctggttccgccaggct
ccagggaaggagcgtgagtttgtagcaggtattaaccgaagtggtgatgtcacaaagtat
gcagacttcgtgaagggccgattctccatctctagagacaacgccaagaacatggtgtac
ctgcaaatgaatagcctgaaacctgaggacacggccctttattactgtgcagccacctgg
gcctacgatacggtaggcgccttaacttccggatataacttctggggccaggggacccag
gtcaccgtctcctca

Data Source:

Alignment settings:

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