abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLTLSCAASGSTSS	1 - 27	27
CDR-H1	RINAMG	28 - 33	6
HFR2	WYRQAPGKQRELVA	34 - 47	14
CDR-H2	SINDGGSTTYADSVKG	48 - 63	16
HFR3	RFTISRDNAKNTMSLLMNSLQPEDTAVYYCNA	64 - 95	32
CDR-H3	RVRFFTTYVNN	96 - 106	11
HFR4	WGQGTQVT	107 - 114	8
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLTLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLTLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLTLSCAASGSTSS	1 - 27	27
	Contact	LQESGGGLVQAGGSLTLSCAASGSTS-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLTLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSTSSRIN---	23 - 30	8
	AbM	GSTSSRINAMG	23 - 33	11
	Kabat	-----RINAMG	28 - 33	6
	Contact	----SRINAMG	27 - 33	7
	IMGT	GSTSSRINA--	23 - 31	9
HFR2	Chothia	AMGWYRQAPGKQRELVASI	31 - 49	19
	AbM	---WYRQAPGKQRELVA--	34 - 47	14
	Kabat	---WYRQAPGKQRELVA--	34 - 47	14
	Contact	---WYRQAPGKQRE-----	34 - 44	11
	IMGT	-MGWYRQAPGKQRELVAS-	32 - 48	17
CDR-H2	Chothia	-----NDGGS---------	50 - 54	5
	AbM	---SINDGGSTT-------	48 - 56	9
	Kabat	---SINDGGSTTYADSVKG	48 - 63	16
	Contact	LVASINDGGSTT-------	45 - 56	12
	IMGT	----INDGGST--------	49 - 55	7
HFR3	Chothia	TTYADSVKGRFTISRDNAKNTMSLLMNSLQPEDTAVYYCNA	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTMSLLMNSLQPEDTAVYYCNA	57 - 95	39
	Kabat	---------RFTISRDNAKNTMSLLMNSLQPEDTAVYYCNA	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTMSLLMNSLQPEDTAVYYC--	57 - 93	37
	IMGT	-TYADSVKGRFTISRDNAKNTMSLLMNSLQPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--RVRFFTTYVNN	96 - 106	11
	AbM	--RVRFFTTYVNN	96 - 106	11
	Kabat	--RVRFFTTYVNN	96 - 106	11
	Contact	NARVRFFTTYVN-	94 - 105	12
	IMGT	NARVRFFTTYVNN	94 - 106	13
HFR4	Chothia	-WGQGTQVT	107 - 114	8
	AbM	-WGQGTQVT	107 - 114	8
	Kabat	-WGQGTQVT	107 - 114	8
	Contact	NWGQGTQVT	106 - 114	9
	IMGT	-WGQGTQVT	107 - 114	8

Accession & Annotations

Accession	CAD22459.1
Source	abYsis-EMBL-IG AJ429746 Submitted 02-FEB-2002 Updated 02-FEB-2002
Name	immunoglobulin heavy chain variable region
Clone	C6
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (30-JAN-2002) to the INSDC. Harmsen M.M., Notifiable Diseases and Pathology, Institute for Animal Science and Health, Edelhertweg 15, 8200 AB Lelystad, NETHERLANDS. Harmsen M.M., Smits C.B. 'Stimulation of chymosin secretion by yeast cells by simultaneous expression of chymosin-binding llama single-domain antibody fragments' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLTLSCAASGSTSSRINAMGWYRQAPGKQRELVASINDGGSTTYADS
VKGRFTISRDNAKNTMSLLMNSLQPEDTAVYYCNARVRFFTTYVNNWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcaggctggggggtctctgacgctctcctgtgca
gcctctggaagcaccagcagcaggatcaatgccatgggctggtaccgccaggctccaggg
aagcagcgcgaattggtcgcgtctattaatgatggtgggagcacaacctatgcagactcc
gtgaagggccgattcaccatttccagggacaacgccaagaacacgatgtctctacttatg
aacagcctgcaacctgaggacacggccgtctattactgtaatgcccgcgtgaggttcttt
accacctacgtaaacaactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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