abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQTGGSLRLSCAVPESTFS	1 - 27	27
CDR-H1	ITSMG	28 - 32	5
HFR2	WYRQASGKERELVA	33 - 46	14
CDR-H2	GIISAGTANYADSVKG	47 - 62	16
HFR3	RFTISIGNTKNTAYLQMNSLKPGDTAVYYCRV	63 - 94	32
CDR-H3	VGTYKGD	95 - 101	7
HFR4		-	-
			101

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQTGGSLRLSCAVP-----	1 - 22	22
	AbM	LQQSGGGLVQTGGSLRLSCAVP-----	1 - 22	22
	Kabat	LQQSGGGLVQTGGSLRLSCAVPESTFS	1 - 27	27
	Contact	LQQSGGGLVQTGGSLRLSCAVPESTF-	1 - 26	26
	IMGT	LQQSGGGLVQTGGSLRLSCAVP-----	1 - 22	22
CDR-H1	Chothia	ESTFSIT---	23 - 29	7
	AbM	ESTFSITSMG	23 - 32	10
	Kabat	-----ITSMG	28 - 32	5
	Contact	----SITSMG	27 - 32	6
	IMGT	ESTFSITS--	23 - 30	8
HFR2	Chothia	SMGWYRQASGKERELVAGI	30 - 48	19
	AbM	---WYRQASGKERELVA--	33 - 46	14
	Kabat	---WYRQASGKERELVA--	33 - 46	14
	Contact	---WYRQASGKERE-----	33 - 43	11
	IMGT	-MGWYRQASGKERELVAG-	31 - 47	17
CDR-H2	Chothia	-----ISAGT---------	49 - 53	5
	AbM	---GIISAGTAN-------	47 - 55	9
	Kabat	---GIISAGTANYADSVKG	47 - 62	16
	Contact	LVAGIISAGTAN-------	44 - 55	12
	IMGT	----IISAGTA--------	48 - 54	7
HFR3	Chothia	ANYADSVKGRFTISIGNTKNTAYLQMNSLKPGDTAVYYCRV	54 - 94	41
	AbM	--YADSVKGRFTISIGNTKNTAYLQMNSLKPGDTAVYYCRV	56 - 94	39
	Kabat	---------RFTISIGNTKNTAYLQMNSLKPGDTAVYYCRV	63 - 94	32
	Contact	--YADSVKGRFTISIGNTKNTAYLQMNSLKPGDTAVYYC--	56 - 92	37
	IMGT	-NYADSVKGRFTISIGNTKNTAYLQMNSLKPGDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--VGTYKGD	95 - 101	7
	AbM	--VGTYKGD	95 - 101	7
	Kabat	--VGTYKGD	95 - 101	7
	Contact	RVVGTYKGD	93 - 101	9
	IMGT	RVVGTYKGD	93 - 101	9
HFR4	Chothia		-	-
	AbM		-	-
	Kabat		-	-
	Contact		-	-
	IMGT		-	-

Accession & Annotations

Accession	CAD22460.1
Source	abYsis-EMBL-IG AJ429747 Submitted 02-FEB-2002 Updated 02-FEB-2002
Name	immunoglobulin heavy chain variable region
Clone	C9
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (30-JAN-2002) to the INSDC. Harmsen M.M., Notifiable Diseases and Pathology, Institute for Animal Science and Health, Edelhertweg 15, 8200 AB Lelystad, NETHERLANDS. Harmsen M.M., Smits C.B. 'Stimulation of chymosin secretion by yeast cells by simultaneous expression of chymosin-binding llama single-domain antibody fragments' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQTGGSLRLSCAVPESTFSITSMGWYRQASGKERELVAGIISAGTANYADSV
KGRFTISIGNTKNTAYLQMNSLKPGDTAVYYCRVVGTYKGD

DNA Sequence:

ctgcagcagtctgggggaggcttggtgcagactggggggtctctgagactctcctgcgca
gtccccgaaagcaccttcagtattaccagcatgggctggtaccgccaggcttcagggaaa
gagcgcgaattggtcgccggtattattagtgcgggaaccgcaaattatgcagactccgtg
aagggccgattcaccatctccataggcaacaccaagaacacagcgtatctgcaaatgaac
agcctgaaaccgggggacacggccgtctattactgtcgtgtagtagggacttataagggt
gacc

Data Source:

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