abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGSTFS	1 - 27	27
CDR-H1	INAMG	28 - 32	5
HFR2	WYRQAPGKQRELVA	33 - 46	14
CDR-H2	LISYGGSTKYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	63 - 94	32
CDR-H3	EGSSWKKFDY	95 - 104	10
HFR4	WGQGTQVT	105 - 112	8
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGSTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGSTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSTFSIN---	23 - 29	7
	AbM	GSTFSINAMG	23 - 32	10
	Kabat	-----INAMG	28 - 32	5
	Contact	----SINAMG	27 - 32	6
	IMGT	GSTFSINA--	23 - 30	8
HFR2	Chothia	AMGWYRQAPGKQRELVALI	30 - 48	19
	AbM	---WYRQAPGKQRELVA--	33 - 46	14
	Kabat	---WYRQAPGKQRELVA--	33 - 46	14
	Contact	---WYRQAPGKQRE-----	33 - 43	11
	IMGT	-MGWYRQAPGKQRELVAL-	31 - 47	17
CDR-H2	Chothia	-----SYGGS---------	49 - 53	5
	AbM	---LISYGGSTK-------	47 - 55	9
	Kabat	---LISYGGSTKYADSVKG	47 - 62	16
	Contact	LVALISYGGSTK-------	44 - 55	12
	IMGT	----ISYGGST--------	48 - 54	7
HFR3	Chothia	TKYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	56 - 94	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-KYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--EGSSWKKFDY	95 - 104	10
	AbM	--EGSSWKKFDY	95 - 104	10
	Kabat	--EGSSWKKFDY	95 - 104	10
	Contact	NAEGSSWKKFD-	93 - 103	11
	IMGT	NAEGSSWKKFDY	93 - 104	12
HFR4	Chothia	-WGQGTQVT	105 - 112	8
	AbM	-WGQGTQVT	105 - 112	8
	Kabat	-WGQGTQVT	105 - 112	8
	Contact	YWGQGTQVT	104 - 112	9
	IMGT	-WGQGTQVT	105 - 112	8

Accession & Annotations

Accession	CAD22462.1
Source	abYsis-EMBL-IG AJ429749 Submitted 02-FEB-2002 Updated 02-FEB-2002
Name	immunoglobulin heavy chain variable region
Clone	C14
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (30-JAN-2002) to the INSDC. Harmsen M.M., Notifiable Diseases and Pathology, Institute for Animal Science and Health, Edelhertweg 15, 8200 AB Lelystad, NETHERLANDS. Harmsen M.M., Smits C.B. 'Stimulation of chymosin secretion by yeast cells by simultaneous expression of chymosin-binding llama single-domain antibody fragments' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGSTFSINAMGWYRQAPGKQRELVALISYGGSTKYADSV
KGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNAEGSSWKKFDYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcaggctggggggtctctgagactctcctgtgca
gcctctggaagcaccttcagtatcaatgccatgggctggtaccgccaggctccggggaag
cagcgcgagttggtcgcacttattagttacggtggtagcacaaagtatgcagactccgtg
aagggccgattcaccatctccagagacaacgccaagaacacagtgtatctgcaaatgaac
agcctgaaacctgaggacacggccgtctattactgtaatgcagaaggtagtagttggaag
aagtttgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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