abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGSVQPGGSLRLSCAASGFAFS	1 - 27	27
CDR-H1	INAMD	28 - 32	5
HFR2	WYRQVPGKEREVVA	33 - 46	14
CDR-H2	RISSGGSTNYADAVKG	47 - 62	16
HFR3	RFTISRDNAKQLVFLQMNNLKPEDTAVYYCNS	63 - 94	32
CDR-H3	AYKHNRDS	95 - 102	8
HFR4	WGQGTQVT	103 - 110	8
			110

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGSVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGSVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGSVQPGGSLRLSCAASGFAFS	1 - 27	27
	Contact	LQESGGGSVQPGGSLRLSCAASGFAF-	1 - 26	26
	IMGT	LQESGGGSVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GFAFSIN---	23 - 29	7
	AbM	GFAFSINAMD	23 - 32	10
	Kabat	-----INAMD	28 - 32	5
	Contact	----SINAMD	27 - 32	6
	IMGT	GFAFSINA--	23 - 30	8
HFR2	Chothia	AMDWYRQVPGKEREVVARI	30 - 48	19
	AbM	---WYRQVPGKEREVVA--	33 - 46	14
	Kabat	---WYRQVPGKEREVVA--	33 - 46	14
	Contact	---WYRQVPGKERE-----	33 - 43	11
	IMGT	-MDWYRQVPGKEREVVAR-	31 - 47	17
CDR-H2	Chothia	-----SSGGS---------	49 - 53	5
	AbM	---RISSGGSTN-------	47 - 55	9
	Kabat	---RISSGGSTNYADAVKG	47 - 62	16
	Contact	VVARISSGGSTN-------	44 - 55	12
	IMGT	----ISSGGST--------	48 - 54	7
HFR3	Chothia	TNYADAVKGRFTISRDNAKQLVFLQMNNLKPEDTAVYYCNS	54 - 94	41
	AbM	--YADAVKGRFTISRDNAKQLVFLQMNNLKPEDTAVYYCNS	56 - 94	39
	Kabat	---------RFTISRDNAKQLVFLQMNNLKPEDTAVYYCNS	63 - 94	32
	Contact	--YADAVKGRFTISRDNAKQLVFLQMNNLKPEDTAVYYC--	56 - 92	37
	IMGT	-NYADAVKGRFTISRDNAKQLVFLQMNNLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--AYKHNRDS	95 - 102	8
	AbM	--AYKHNRDS	95 - 102	8
	Kabat	--AYKHNRDS	95 - 102	8
	Contact	NSAYKHNRD-	93 - 101	9
	IMGT	NSAYKHNRDS	93 - 102	10
HFR4	Chothia	-WGQGTQVT	103 - 110	8
	AbM	-WGQGTQVT	103 - 110	8
	Kabat	-WGQGTQVT	103 - 110	8
	Contact	SWGQGTQVT	102 - 110	9
	IMGT	-WGQGTQVT	103 - 110	8

Accession & Annotations

Accession	CAD22474.1
Source	abYsis-EMBL-IG AJ429761 Submitted 02-FEB-2002 Updated 02-FEB-2002
Name	immunoglobulin heavy chain variable region
Clone	C207
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: CAD22471.1
References	Harmsen M.M. Submitted (30-JAN-2002) to the INSDC. Harmsen M.M., Notifiable Diseases and Pathology, Institute for Animal Science and Health, Edelhertweg 15, 8200 AB Lelystad, NETHERLANDS. Harmsen M.M., Smits C.B. 'Stimulation of chymosin secretion by yeast cells by simultaneous expression of chymosin-binding llama single-domain antibody fragments' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGSVQPGGSLRLSCAASGFAFSINAMDWYRQVPGKEREVVARISSGGSTNYADAV
KGRFTISRDNAKQLVFLQMNNLKPEDTAVYYCNSAYKHNRDSWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggctcggtgcagcctggggggtctctgagactctcctgtgca
gcctctggattcgccttcagtatcaatgccatggactggtaccgccaggttccagggaag
gagcgcgaggtggtcgcacgtattagtagtggtggtagcacaaactatgcagacgccgtg
aagggccgattcaccatctccagagacaacgccaagcaactggtgtttctgcaaatgaac
aacctgaaacctgaggacacggccgtctattactgtaactcagcatacaaacacaatcgt
gattcctggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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