abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCTASGRTFS	1 - 27	27
CDR-H1	DYIMG	28 - 32	5
HFR2	WFRQAPGKERERVA	33 - 46	14
CDR-H2	TINWTGAITYVVDAVKG	47 - 63	17
HFR3	RFSISRDNAKNTVYLQMNGVKPEDTAVYYCAA	64 - 95	32
CDR-H3	GRSGVTVRNSES	96 - 107	12
HFR4	WGQGTQVT	108 - 115	8
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCTAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCTAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCTASGRTFS	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCTASGRTF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCTAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSDY---	23 - 29	7
	AbM	GRTFSDYIMG	23 - 32	10
	Kabat	-----DYIMG	28 - 32	5
	Contact	----SDYIMG	27 - 32	6
	IMGT	GRTFSDYI--	23 - 30	8
HFR2	Chothia	IMGWFRQAPGKERERVATI	30 - 48	19
	AbM	---WFRQAPGKERERVA--	33 - 46	14
	Kabat	---WFRQAPGKERERVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKERERVAT-	31 - 47	17
CDR-H2	Chothia	-----NWTGAI---------	49 - 54	6
	AbM	---TINWTGAITY-------	47 - 56	10
	Kabat	---TINWTGAITYVVDAVKG	47 - 63	17
	Contact	RVATINWTGAITY-------	44 - 56	13
	IMGT	----INWTGAIT--------	48 - 55	8
HFR3	Chothia	TYVVDAVKGRFSISRDNAKNTVYLQMNGVKPEDTAVYYCAA	55 - 95	41
	AbM	--VVDAVKGRFSISRDNAKNTVYLQMNGVKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFSISRDNAKNTVYLQMNGVKPEDTAVYYCAA	64 - 95	32
	Contact	--VVDAVKGRFSISRDNAKNTVYLQMNGVKPEDTAVYYC--	57 - 93	37
	IMGT	-YVVDAVKGRFSISRDNAKNTVYLQMNGVKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GRSGVTVRNSES	96 - 107	12
	AbM	--GRSGVTVRNSES	96 - 107	12
	Kabat	--GRSGVTVRNSES	96 - 107	12
	Contact	AAGRSGVTVRNSE-	94 - 106	13
	IMGT	AAGRSGVTVRNSES	94 - 107	14
HFR4	Chothia	-WGQGTQVT	108 - 115	8
	AbM	-WGQGTQVT	108 - 115	8
	Kabat	-WGQGTQVT	108 - 115	8
	Contact	SWGQGTQVT	107 - 115	9
	IMGT	-WGQGTQVT	108 - 115	8

Accession & Annotations

Accession	CAD22479.1
Source	abYsis-EMBL-IG AJ429766 Submitted 02-FEB-2002 Updated 02-FEB-2002
Name	immunoglobulin heavy chain variable region
Clone	C227
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (30-JAN-2002) to the INSDC. Harmsen M.M., Notifiable Diseases and Pathology, Institute for Animal Science and Health, Edelhertweg 15, 8200 AB Lelystad, NETHERLANDS. Harmsen M.M., Smits C.B. 'Stimulation of chymosin secretion by yeast cells by simultaneous expression of chymosin-binding llama single-domain antibody fragments' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCTASGRTFSDYIMGWFRQAPGKERERVATINWTGAITYVVDA
VKGRFSISRDNAKNTVYLQMNGVKPEDTAVYYCAAGRSGVTVRNSESWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtaca
gcctctggacgcaccttcagtgactatattatgggctggttccgtcaggctccagggaag
gagcgtgaacgcgtagcaacaattaactggactggtgctatcacatacgttgtagacgcc
gtgaagggccgattcagcatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacggcgtgaaacctgaggacacggccgtctattactgcgcagcaggccgctcgggagtg
accgtgaggaactctgaatcttggggtcaggggacccaggtcacc

Data Source:

Alignment settings:

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