abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGDSLRLSCVASGRTFS	1 - 27	27
CDR-H1	NYTMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	HITGSGKLAYVADSVKG	47 - 63	17
HFR3	RFIISRDNAKNTVYLQMNNLKPEDTALYYCAA	64 - 95	32
CDR-H3	TILARRPSPGAYDY	96 - 109	14
HFR4	WGQGAQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGDSLRLSCVAS-----	1 - 22	22
	AbM	LQESGGGLVQAGDSLRLSCVAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGDSLRLSCVASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGDSLRLSCVASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGDSLRLSCVAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSNY---	23 - 29	7
	AbM	GRTFSNYTMG	23 - 32	10
	Kabat	-----NYTMG	28 - 32	5
	Contact	----SNYTMG	27 - 32	6
	IMGT	GRTFSNYT--	23 - 30	8
HFR2	Chothia	TMGWFRQAPGKEREFVAHI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAH-	31 - 47	17
CDR-H2	Chothia	-----TGSGKL---------	49 - 54	6
	AbM	---HITGSGKLAY-------	47 - 56	10
	Kabat	---HITGSGKLAYVADSVKG	47 - 63	17
	Contact	FVAHITGSGKLAY-------	44 - 56	13
	IMGT	----ITGSGKLA--------	48 - 55	8
HFR3	Chothia	AYVADSVKGRFIISRDNAKNTVYLQMNNLKPEDTALYYCAA	55 - 95	41
	AbM	--VADSVKGRFIISRDNAKNTVYLQMNNLKPEDTALYYCAA	57 - 95	39
	Kabat	---------RFIISRDNAKNTVYLQMNNLKPEDTALYYCAA	64 - 95	32
	Contact	--VADSVKGRFIISRDNAKNTVYLQMNNLKPEDTALYYC--	57 - 93	37
	IMGT	-YVADSVKGRFIISRDNAKNTVYLQMNNLKPEDTALYYC--	56 - 93	38
CDR-H3	Chothia	--TILARRPSPGAYDY	96 - 109	14
	AbM	--TILARRPSPGAYDY	96 - 109	14
	Kabat	--TILARRPSPGAYDY	96 - 109	14
	Contact	AATILARRPSPGAYD-	94 - 108	15
	IMGT	AATILARRPSPGAYDY	94 - 109	16
HFR4	Chothia	-WGQGAQVT	110 - 117	8
	AbM	-WGQGAQVT	110 - 117	8
	Kabat	-WGQGAQVT	110 - 117	8
	Contact	YWGQGAQVT	109 - 117	9
	IMGT	-WGQGAQVT	110 - 117	8

Accession & Annotations

Accession	CAD22482.1
Source	abYsis-EMBL-IG AJ429769 Submitted 02-FEB-2002 Updated 02-FEB-2002
Name	immunoglobulin heavy chain variable region
Clone	C230
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (30-JAN-2002) to the INSDC. Harmsen M.M., Notifiable Diseases and Pathology, Institute for Animal Science and Health, Edelhertweg 15, 8200 AB Lelystad, NETHERLANDS. Harmsen M.M., Smits C.B. 'Stimulation of chymosin secretion by yeast cells by simultaneous expression of chymosin-binding llama single-domain antibody fragments' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGDSLRLSCVASGRTFSNYTMGWFRQAPGKEREFVAHITGSGKLAYVADS
VKGRFIISRDNAKNTVYLQMNNLKPEDTALYYCAATILARRPSPGAYDYWGQGAQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctggggactctctgagactctcctgtgta
gcctctggacgcaccttcagtaactataccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcgcatattacgggaagtggtaagctcgcatacgttgcagactcc
gtgaagggccgattcatcatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacaacctgaaacctgaagacacggccctttattactgtgcagcaaccatcctcgctcgg
cggccgtcaccaggggcatatgactactggggccagggggcccaggtcacc

Data Source:

Alignment settings:

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