abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGSVQAGGSLRLSCAASGRTAS	1 - 27	27
CDR-H1	SWAIH	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISSSGDYTYYADSVKG	47 - 63	17
HFR3	RFTISRDNTKVTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	DSNYRAILLGTSLNY	96 - 110	15
HFR4	WGQGTQVT	111 - 118	8
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGSVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGSVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGSVQAGGSLRLSCAASGRTAS	1 - 27	27
	Contact	LQQSGGGSVQAGGSLRLSCAASGRTA-	1 - 26	26
	IMGT	LQQSGGGSVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTASSW---	23 - 29	7
	AbM	GRTASSWAIH	23 - 32	10
	Kabat	-----SWAIH	28 - 32	5
	Contact	----SSWAIH	27 - 32	6
	IMGT	GRTASSWA--	23 - 30	8
HFR2	Chothia	AIHWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-IHWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SSSGDY---------	49 - 54	6
	AbM	---AISSSGDYTY-------	47 - 56	10
	Kabat	---AISSSGDYTYYADSVKG	47 - 63	17
	Contact	FVAAISSSGDYTY-------	44 - 56	13
	IMGT	----ISSSGDYT--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNTKVTVYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNTKVTVYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNTKVTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNTKVTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNTKVTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DSNYRAILLGTSLNY	96 - 110	15
	AbM	--DSNYRAILLGTSLNY	96 - 110	15
	Kabat	--DSNYRAILLGTSLNY	96 - 110	15
	Contact	AADSNYRAILLGTSLN-	94 - 109	16
	IMGT	AADSNYRAILLGTSLNY	94 - 110	17
HFR4	Chothia	-WGQGTQVT	111 - 118	8
	AbM	-WGQGTQVT	111 - 118	8
	Kabat	-WGQGTQVT	111 - 118	8
	Contact	YWGQGTQVT	110 - 118	9
	IMGT	-WGQGTQVT	111 - 118	8

Accession & Annotations

Accession	CAF32422.1
Source	abYsis-EMBL-IG AJ629031 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-5
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGSVQAGGSLRLSCAASGRTASSWAIHWFRQAPGKEREFVAAISSSGDYTYYADS
VKGRFTISRDNTKVTVYLQMNSLKPEDTAVYYCAADSNYRAILLGTSLNYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggatcggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcacagccagtagctgggccatacactggttccgccaggctccaggaaag
gagcgtgagtttgtcgcagctattagctctagtggtgattacacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacaccaaggtcacggtatatctgcaaatg
aacagcctgaaacctgaggatacggccgtttattactgtgcagcggacagtaattatcgt
gcgatactacttggtacaagccttaactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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