abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQNGDSLRLSCAASGRSFR	1 - 27	27
CDR-H1	TYAMG	28 - 32	5
HFR2	WFRQAPGKEREIVG	33 - 46	14
CDR-H2	ALSWSDSGTYYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	DPSYARIVGSGRYIIEY	96 - 112	17
HFR4	WGQGTQVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQNGDSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQNGDSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQNGDSLRLSCAASGRSFR	1 - 27	27
	Contact	LQQSGGGLVQNGDSLRLSCAASGRSF-	1 - 26	26
	IMGT	LQQSGGGLVQNGDSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRSFRTY---	23 - 29	7
	AbM	GRSFRTYAMG	23 - 32	10
	Kabat	-----TYAMG	28 - 32	5
	Contact	----RTYAMG	27 - 32	6
	IMGT	GRSFRTYA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREIVGAL	30 - 48	19
	AbM	---WFRQAPGKEREIVG--	33 - 46	14
	Kabat	---WFRQAPGKEREIVG--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREIVGA-	31 - 47	17
CDR-H2	Chothia	-----SWSDSG---------	49 - 54	6
	AbM	---ALSWSDSGTY-------	47 - 56	10
	Kabat	---ALSWSDSGTYYADSVKG	47 - 63	17
	Contact	IVGALSWSDSGTY-------	44 - 56	13
	IMGT	----LSWSDSGT--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTLYLQMDSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMDSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNAKNTLYLQMDSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DPSYARIVGSGRYIIEY	96 - 112	17
	AbM	--DPSYARIVGSGRYIIEY	96 - 112	17
	Kabat	--DPSYARIVGSGRYIIEY	96 - 112	17
	Contact	AADPSYARIVGSGRYIIE-	94 - 111	18
	IMGT	AADPSYARIVGSGRYIIEY	94 - 112	19
HFR4	Chothia	-WGQGTQVT	113 - 120	8
	AbM	-WGQGTQVT	113 - 120	8
	Kabat	-WGQGTQVT	113 - 120	8
	Contact	YWGQGTQVT	112 - 120	9
	IMGT	-WGQGTQVT	113 - 120	8

Accession & Annotations

Accession	CAF32423.1
Source	abYsis-EMBL-IG AJ629032 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-6
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQNGDSLRLSCAASGRSFRTYAMGWFRQAPGKEREIVGALSWSDSGTYYADS
VKGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADPSYARIVGSGRYIIEYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcagaatggggactctctgagactctcctgtgca
gcctctggacgctccttcagaacctatgccatgggctggttccgccaggctccagggaag
gagcgtgaaattgtaggcgctcttagttggagtgatagtggcacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacactgtatctgcaaatg
gacagcctgaaacctgaggacacggccgtttattactgtgcagcagatccgtcgtatgct
cgtattgtgggtagtggtcggtacatcattgagtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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