abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGSVQAGGSLRLSCAASGRTAS	1 - 27	27
CDR-H1	NWATH	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISSSGGYTYYADSVKG	47 - 63	17
HFR3	RFTISRDNTKSTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	DSVNRAIMLGTSLDY	96 - 110	15
HFR4	WGQGTQVT	111 - 118	8
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGSVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGSVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGSVQAGGSLRLSCAASGRTAS	1 - 27	27
	Contact	LQESGGGSVQAGGSLRLSCAASGRTA-	1 - 26	26
	IMGT	LQESGGGSVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTASNW---	23 - 29	7
	AbM	GRTASNWATH	23 - 32	10
	Kabat	-----NWATH	28 - 32	5
	Contact	----SNWATH	27 - 32	6
	IMGT	GRTASNWA--	23 - 30	8
HFR2	Chothia	ATHWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-THWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SSSGGY---------	49 - 54	6
	AbM	---AISSSGGYTY-------	47 - 56	10
	Kabat	---AISSSGGYTYYADSVKG	47 - 63	17
	Contact	FVAAISSSGGYTY-------	44 - 56	13
	IMGT	----ISSSGGYT--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNTKSTVYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNTKSTVYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNTKSTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNTKSTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNTKSTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DSVNRAIMLGTSLDY	96 - 110	15
	AbM	--DSVNRAIMLGTSLDY	96 - 110	15
	Kabat	--DSVNRAIMLGTSLDY	96 - 110	15
	Contact	AADSVNRAIMLGTSLD-	94 - 109	16
	IMGT	AADSVNRAIMLGTSLDY	94 - 110	17
HFR4	Chothia	-WGQGTQVT	111 - 118	8
	AbM	-WGQGTQVT	111 - 118	8
	Kabat	-WGQGTQVT	111 - 118	8
	Contact	YWGQGTQVT	110 - 118	9
	IMGT	-WGQGTQVT	111 - 118	8

Accession & Annotations

Accession	CAF32424.1
Source	abYsis-EMBL-IG AJ629033 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-8
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGSVQAGGSLRLSCAASGRTASNWATHWFRQAPGKEREFVAAISSSGGYTYYADS
VKGRFTISRDNTKSTVYLQMNSLKPEDTAVYYCAADSVNRAIMLGTSLDYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggatcggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcacagccagtaactgggccacacactggttccgccaggctccaggaaag
gagcgtgaatttgtagcagctattagctcgagtggtggttacacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacaccaagagcacggtatatctgcaaatg
aacagcctgaaacctgaggatacggccgtttattactgtgcagcagacagtgtcaatcgt
gcgataatgcttggtacaagccttgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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