abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRSDS	1 - 27	27
CDR-H1	TDTMT	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	SVSWIANTYYADSVKG	47 - 62	16
HFR3	RFTASRDYTKNTVYLQMNNLTPEDTAVYYCAA	63 - 94	32
CDR-H3	ADHGSRWWRQVADITTYDY	95 - 113	19
HFR4	WGQGTQVT	114 - 121	8
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRSDS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRSD-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRSDSTD---	23 - 29	7
	AbM	GRSDSTDTMT	23 - 32	10
	Kabat	-----TDTMT	28 - 32	5
	Contact	----STDTMT	27 - 32	6
	IMGT	GRSDSTDT--	23 - 30	8
HFR2	Chothia	TMTWFRQAPGKEREFVASV	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MTWFRQAPGKEREFVAS-	31 - 47	17
CDR-H2	Chothia	-----SWIAN---------	49 - 53	5
	AbM	---SVSWIANTY-------	47 - 55	9
	Kabat	---SVSWIANTYYADSVKG	47 - 62	16
	Contact	FVASVSWIANTY-------	44 - 55	12
	IMGT	----VSWIANT--------	48 - 54	7
HFR3	Chothia	TYYADSVKGRFTASRDYTKNTVYLQMNNLTPEDTAVYYCAA	54 - 94	41
	AbM	--YADSVKGRFTASRDYTKNTVYLQMNNLTPEDTAVYYCAA	56 - 94	39
	Kabat	---------RFTASRDYTKNTVYLQMNNLTPEDTAVYYCAA	63 - 94	32
	Contact	--YADSVKGRFTASRDYTKNTVYLQMNNLTPEDTAVYYC--	56 - 92	37
	IMGT	-YYADSVKGRFTASRDYTKNTVYLQMNNLTPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--ADHGSRWWRQVADITTYDY	95 - 113	19
	AbM	--ADHGSRWWRQVADITTYDY	95 - 113	19
	Kabat	--ADHGSRWWRQVADITTYDY	95 - 113	19
	Contact	AAADHGSRWWRQVADITTYD-	93 - 112	20
	IMGT	AAADHGSRWWRQVADITTYDY	93 - 113	21
HFR4	Chothia	-WGQGTQVT	114 - 121	8
	AbM	-WGQGTQVT	114 - 121	8
	Kabat	-WGQGTQVT	114 - 121	8
	Contact	YWGQGTQVT	113 - 121	9
	IMGT	-WGQGTQVT	114 - 121	8

Accession & Annotations

Accession	CAF32426.1
Source	abYsis-EMBL-IG AJ629035 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-10
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: CAF32435.1 CAF32436.1
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRSDSTDTMTWFRQAPGKEREFVASVSWIANTYYADSV
KGRFTASRDYTKNTVYLQMNNLTPEDTAVYYCAAADHGSRWWRQVADITTYDYWGQGTQV
T

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgcc
gcctctggtcgcagcgacagtacagataccatgacctggttccgccaggctccagggaag
gagcgtgaatttgtagcgagtgttagctggattgctaacacatactatgcagactccgtg
aagggccgattcaccgcctccagagactacaccaagaacacggtgtatctgcaaatgaac
aatttgacgcctgaggacacggccgtgtattactgtgcagcagccgaccacggtagtagg
tggtggcgtcaagtggccgatattacgacctatgactactggggccaggggacccaggtc
acc

Data Source:

Alignment settings:

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