abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGSIFS	1 - 27	27
CDR-H1	INAAG	28 - 32	5
HFR2	WYRQAPGKQRELVA	33 - 46	14
CDR-H2	YMSSTGSTNYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	63 - 94	32
CDR-H3	DGIAVLAGRTDQYDF	95 - 109	15
HFR4	WGQGTQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGSIFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGSIF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSIFSIN---	23 - 29	7
	AbM	GSIFSINAAG	23 - 32	10
	Kabat	-----INAAG	28 - 32	5
	Contact	----SINAAG	27 - 32	6
	IMGT	GSIFSINA--	23 - 30	8
HFR2	Chothia	AAGWYRQAPGKQRELVAYM	30 - 48	19
	AbM	---WYRQAPGKQRELVA--	33 - 46	14
	Kabat	---WYRQAPGKQRELVA--	33 - 46	14
	Contact	---WYRQAPGKQRE-----	33 - 43	11
	IMGT	-AGWYRQAPGKQRELVAY-	31 - 47	17
CDR-H2	Chothia	-----SSTGS---------	49 - 53	5
	AbM	---YMSSTGSTN-------	47 - 55	9
	Kabat	---YMSSTGSTNYADSVKG	47 - 62	16
	Contact	LVAYMSSTGSTN-------	44 - 55	12
	IMGT	----MSSTGST--------	48 - 54	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	56 - 94	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--DGIAVLAGRTDQYDF	95 - 109	15
	AbM	--DGIAVLAGRTDQYDF	95 - 109	15
	Kabat	--DGIAVLAGRTDQYDF	95 - 109	15
	Contact	NADGIAVLAGRTDQYD-	93 - 108	16
	IMGT	NADGIAVLAGRTDQYDF	93 - 109	17
HFR4	Chothia	-WGQGTQVT	110 - 117	8
	AbM	-WGQGTQVT	110 - 117	8
	Kabat	-WGQGTQVT	110 - 117	8
	Contact	FWGQGTQVT	109 - 117	9
	IMGT	-WGQGTQVT	110 - 117	8

Accession & Annotations

Accession	CAF32427.1
Source	abYsis-EMBL-IG AJ629036 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-11
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGSIFSINAAGWYRQAPGKQRELVAYMSSTGSTNYADSV
KGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNADGIAVLAGRTDQYDFWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggaagcatcttcagtatcaatgccgcgggctggtaccgccaggctccagggaag
cagcgcgagttggtcgcatatatgtctagtactggtagcacaaactatgcagactccgtg
aagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatgaac
agcctgaaacctgaggacacggccgtctattactgtaatgcagatgggatagcagtacta
gctggtaggactgatcagtatgacttctggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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