abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQPGGSLRLSCAASGNISS	1 - 27	27
CDR-H1	VNFMA	28 - 32	5
HFR2	WYRQNPGTQRELVA	33 - 46	14
CDR-H2	QIPSGGYPVYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTLYLQMNGLKPEDTAVYYCYA	63 - 94	32
CDR-H3	AARTWFYNYNY	95 - 105	11
HFR4	WGQGTQVT	106 - 113	8
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQPGGSLRLSCAASGNISS	1 - 27	27
	Contact	LQQSGGGLVQPGGSLRLSCAASGNIS-	1 - 26	26
	IMGT	LQQSGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GNISSVN---	23 - 29	7
	AbM	GNISSVNFMA	23 - 32	10
	Kabat	-----VNFMA	28 - 32	5
	Contact	----SVNFMA	27 - 32	6
	IMGT	GNISSVNF--	23 - 30	8
HFR2	Chothia	FMAWYRQNPGTQRELVAQI	30 - 48	19
	AbM	---WYRQNPGTQRELVA--	33 - 46	14
	Kabat	---WYRQNPGTQRELVA--	33 - 46	14
	Contact	---WYRQNPGTQRE-----	33 - 43	11
	IMGT	-MAWYRQNPGTQRELVAQ-	31 - 47	17
CDR-H2	Chothia	-----PSGGY---------	49 - 53	5
	AbM	---QIPSGGYPV-------	47 - 55	9
	Kabat	---QIPSGGYPVYADSVKG	47 - 62	16
	Contact	LVAQIPSGGYPV-------	44 - 55	12
	IMGT	----IPSGGYP--------	48 - 54	7
HFR3	Chothia	PVYADSVKGRFTISRDNAKNTLYLQMNGLKPEDTAVYYCYA	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNGLKPEDTAVYYCYA	56 - 94	39
	Kabat	---------RFTISRDNAKNTLYLQMNGLKPEDTAVYYCYA	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNGLKPEDTAVYYC--	56 - 92	37
	IMGT	-VYADSVKGRFTISRDNAKNTLYLQMNGLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--AARTWFYNYNY	95 - 105	11
	AbM	--AARTWFYNYNY	95 - 105	11
	Kabat	--AARTWFYNYNY	95 - 105	11
	Contact	YAAARTWFYNYN-	93 - 104	12
	IMGT	YAAARTWFYNYNY	93 - 105	13
HFR4	Chothia	-WGQGTQVT	106 - 113	8
	AbM	-WGQGTQVT	106 - 113	8
	Kabat	-WGQGTQVT	106 - 113	8
	Contact	YWGQGTQVT	105 - 113	9
	IMGT	-WGQGTQVT	106 - 113	8

Accession & Annotations

Accession	CAF32428.1
Source	abYsis-EMBL-IG AJ629037 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-12
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQPGGSLRLSCAASGNISSVNFMAWYRQNPGTQRELVAQIPSGGYPVYADSV
KGRFTISRDNAKNTLYLQMNGLKPEDTAVYYCYAAARTWFYNYNYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggaaatatctctagcgtcaatttcatggcctggtaccgccagaatccagggact
cagcgcgagttggtcgcacaaattccgagtggcggttacccggtctatgctgactccgtg
aagggccgattcaccatctccagagacaacgccaagaacacgctgtatctgcaaatgaac
ggcctgaaacctgaggacacggccgtctattactgctatgccgcagcgagaacttggttc
tataattataactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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