abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASRSVAS	1 - 27	27
CDR-H1	INVMG	28 - 32	5
HFR2	WFRQVPGREREFVG	33 - 46	14
CDR-H2	AIGLSGGNTYYHHSVKG	47 - 63	17
HFR3	RFTVSRDRAKNTVYLQMDSLKSEDTAIYYCAA	64 - 95	32
CDR-H3	DTGLAYFSYEYSRRPSDYGY	96 - 115	20
HFR4	WGQGTQVT	116 - 123	8
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASRSVAS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASRSVA-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	RSVASIN---	23 - 29	7
	AbM	RSVASINVMG	23 - 32	10
	Kabat	-----INVMG	28 - 32	5
	Contact	----SINVMG	27 - 32	6
	IMGT	RSVASINV--	23 - 30	8
HFR2	Chothia	VMGWFRQVPGREREFVGAI	30 - 48	19
	AbM	---WFRQVPGREREFVG--	33 - 46	14
	Kabat	---WFRQVPGREREFVG--	33 - 46	14
	Contact	---WFRQVPGRERE-----	33 - 43	11
	IMGT	-MGWFRQVPGREREFVGA-	31 - 47	17
CDR-H2	Chothia	-----GLSGGN---------	49 - 54	6
	AbM	---AIGLSGGNTY-------	47 - 56	10
	Kabat	---AIGLSGGNTYYHHSVKG	47 - 63	17
	Contact	FVGAIGLSGGNTY-------	44 - 56	13
	IMGT	----IGLSGGNT--------	48 - 55	8
HFR3	Chothia	TYYHHSVKGRFTVSRDRAKNTVYLQMDSLKSEDTAIYYCAA	55 - 95	41
	AbM	--YHHSVKGRFTVSRDRAKNTVYLQMDSLKSEDTAIYYCAA	57 - 95	39
	Kabat	---------RFTVSRDRAKNTVYLQMDSLKSEDTAIYYCAA	64 - 95	32
	Contact	--YHHSVKGRFTVSRDRAKNTVYLQMDSLKSEDTAIYYC--	57 - 93	37
	IMGT	-YYHHSVKGRFTVSRDRAKNTVYLQMDSLKSEDTAIYYC--	56 - 93	38
CDR-H3	Chothia	--DTGLAYFSYEYSRRPSDYGY	96 - 115	20
	AbM	--DTGLAYFSYEYSRRPSDYGY	96 - 115	20
	Kabat	--DTGLAYFSYEYSRRPSDYGY	96 - 115	20
	Contact	AADTGLAYFSYEYSRRPSDYG-	94 - 114	21
	IMGT	AADTGLAYFSYEYSRRPSDYGY	94 - 115	22
HFR4	Chothia	-WGQGTQVT	116 - 123	8
	AbM	-WGQGTQVT	116 - 123	8
	Kabat	-WGQGTQVT	116 - 123	8
	Contact	YWGQGTQVT	115 - 123	9
	IMGT	-WGQGTQVT	116 - 123	8

Accession & Annotations

Accession	CAF32431.1
Source	abYsis-EMBL-IG AJ629040 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-15
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASRSVASINVMGWFRQVPGREREFVGAIGLSGGNTYYHHS
VKGRFTVSRDRAKNTVYLQMDSLKSEDTAIYYCAADTGLAYFSYEYSRRPSDYGYWGQGT
QVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcaggctggggggtctctgagactctcctgtgca
gcctctcgaagcgtcgcgagtatcaatgtcatgggctggttccgccaggttccagggagg
gagcgtgagtttgtaggagctatcggcttgagtggtggtaacacatactatcatcactcc
gtgaagggccgattcaccgtctccagagaccgcgccaagaacacggtgtatctgcaaatg
gacagcctgaaatctgaggacacggccatttattactgtgcagcagatacgggacttgca
tactttagttatgagtacagtaggaggccatcagattatggctactggggccaggggacc
caggtcacc

Data Source:

Alignment settings:

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