abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRT	1 - 25	25
CDR-H1	DTMT	26 - 29	4
HFR2	WFRQAPGKEREFVA	30 - 43	14
CDR-H2	SISWIDNTNYADSVKG	44 - 59	16
HFR3	RFTVSRDYTKNTMYLQMNNLAPEDTAVYYCAA	60 - 91	32
CDR-H3	ADHGSRWWRQMADATTYDY	92 - 110	19
HFR4	WGQGTQVT	111 - 118	8
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS---	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS---	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRT	1 - 25	25
	Contact	LQESGGGLVQAGGSLRLSCAASGRT	1 - 25	25
	IMGT	LQESGGGLVQAGGSLRLSCAAS---	1 - 22	22
CDR-H1	Chothia	GRTD---	23 - 26	4
	AbM	GRTDTMT	23 - 29	7
	Kabat	---DTMT	26 - 29	4
	Contact	---DTMT	26 - 29	4
	IMGT	GRTDT--	23 - 27	5
HFR2	Chothia	TMTWFRQAPGKEREFVASI	27 - 45	19
	AbM	---WFRQAPGKEREFVA--	30 - 43	14
	Kabat	---WFRQAPGKEREFVA--	30 - 43	14
	Contact	---WFRQAPGKERE-----	30 - 40	11
	IMGT	-MTWFRQAPGKEREFVAS-	28 - 44	17
CDR-H2	Chothia	-----SWIDN---------	46 - 50	5
	AbM	---SISWIDNTN-------	44 - 52	9
	Kabat	---SISWIDNTNYADSVKG	44 - 59	16
	Contact	FVASISWIDNTN-------	41 - 52	12
	IMGT	----ISWIDNT--------	45 - 51	7
HFR3	Chothia	TNYADSVKGRFTVSRDYTKNTMYLQMNNLAPEDTAVYYCAA	51 - 91	41
	AbM	--YADSVKGRFTVSRDYTKNTMYLQMNNLAPEDTAVYYCAA	53 - 91	39
	Kabat	---------RFTVSRDYTKNTMYLQMNNLAPEDTAVYYCAA	60 - 91	32
	Contact	--YADSVKGRFTVSRDYTKNTMYLQMNNLAPEDTAVYYC--	53 - 89	37
	IMGT	-NYADSVKGRFTVSRDYTKNTMYLQMNNLAPEDTAVYYC--	52 - 89	38
CDR-H3	Chothia	--ADHGSRWWRQMADATTYDY	92 - 110	19
	AbM	--ADHGSRWWRQMADATTYDY	92 - 110	19
	Kabat	--ADHGSRWWRQMADATTYDY	92 - 110	19
	Contact	AAADHGSRWWRQMADATTYD-	90 - 109	20
	IMGT	AAADHGSRWWRQMADATTYDY	90 - 110	21
HFR4	Chothia	-WGQGTQVT	111 - 118	8
	AbM	-WGQGTQVT	111 - 118	8
	Kabat	-WGQGTQVT	111 - 118	8
	Contact	YWGQGTQVT	110 - 118	9
	IMGT	-WGQGTQVT	111 - 118	8

Accession & Annotations

Accession	CAF32432.1
Source	abYsis-EMBL-IG AJ629041 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-16
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTDTMTWFRQAPGKEREFVASISWIDNTNYADSVKGR
FTVSRDYTKNTMYLQMNNLAPEDTAVYYCAAADHGSRWWRQMADATTYDYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggtcgcaccgacaccatgacctggttccgccaggctccagggaaggagcgtgaa
tttgtagcgagtattagctggattgataacacaaactatgcagactccgtgaagggccga
ttcaccgtctccagagactacaccaagaacacgatgtatctgcaaatgaacaatttggcg
cctgaggacacggccgtgtattactgtgcagcagccgaccacggtagtaggtggtggcgt
caaatggccgatgctacgacctatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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