abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGFVQPGGSLRLSCAASGFTFS	1 - 27	27
CDR-H1	SYWMY	28 - 32	5
HFR2	WVRQAPGKGLEWVS	33 - 46	14
CDR-H2	VIDSGGSSTNYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTLYLQMNSLRSADTAVYYCAK	64 - 95	32
CDR-H3	ARGRGFVSGPDSLD	96 - 109	14
HFR4	RGQGTQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGFVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGFVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGFVQPGGSLRLSCAASGFTFS	1 - 27	27
	Contact	LQESGGGFVQPGGSLRLSCAASGFTF-	1 - 26	26
	IMGT	LQESGGGFVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GFTFSSY---	23 - 29	7
	AbM	GFTFSSYWMY	23 - 32	10
	Kabat	-----SYWMY	28 - 32	5
	Contact	----SSYWMY	27 - 32	6
	IMGT	GFTFSSYW--	23 - 30	8
HFR2	Chothia	WMYWVRQAPGKGLEWVSVI	30 - 48	19
	AbM	---WVRQAPGKGLEWVS--	33 - 46	14
	Kabat	---WVRQAPGKGLEWVS--	33 - 46	14
	Contact	---WVRQAPGKGLE-----	33 - 43	11
	IMGT	-MYWVRQAPGKGLEWVSV-	31 - 47	17
CDR-H2	Chothia	-----DSGGSS---------	49 - 54	6
	AbM	---VIDSGGSSTN-------	47 - 56	10
	Kabat	---VIDSGGSSTNYADSVKG	47 - 63	17
	Contact	WVSVIDSGGSSTN-------	44 - 56	13
	IMGT	----IDSGGSST--------	48 - 55	8
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTLYLQMNSLRSADTAVYYCAK	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNSLRSADTAVYYCAK	57 - 95	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLRSADTAVYYCAK	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNSLRSADTAVYYC--	57 - 93	37
	IMGT	-NYADSVKGRFTISRDNAKNTLYLQMNSLRSADTAVYYC--	56 - 93	38
CDR-H3	Chothia	--ARGRGFVSGPDSLD	96 - 109	14
	AbM	--ARGRGFVSGPDSLD	96 - 109	14
	Kabat	--ARGRGFVSGPDSLD	96 - 109	14
	Contact	AKARGRGFVSGPDSL-	94 - 108	15
	IMGT	AKARGRGFVSGPDSLD	94 - 109	16
HFR4	Chothia	-RGQGTQVT	110 - 117	8
	AbM	-RGQGTQVT	110 - 117	8
	Kabat	-RGQGTQVT	110 - 117	8
	Contact	DRGQGTQVT	109 - 117	9
	IMGT	-RGQGTQVT	110 - 117	8

Accession & Annotations

Accession	CAF32433.1
Source	abYsis-EMBL-IG AJ629042 Submitted 01-MAR-2004 Updated 13-OCT-2005
Name	single-domain immunoglobulin heavy chain variable region
Clone	VI-18
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (26-FEB-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group of WUR, Edelhertweg 15, 8219 PH Lelystad, NETHERLANDS. Harmsen M.M., Solt-Smits C.S., Fijten H.P.D., Van Setten M. 'Prolonged in vivo residence times of llama single-domain antibody fragments in pigs by binding to porcine immunoglobulins' Vaccine 23(41):4926-4934(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGFVQPGGSLRLSCAASGFTFSSYWMYWVRQAPGKGLEWVSVIDSGGSSTNYADS
VKGRFTISRDNAKNTLYLQMNSLRSADTAVYYCAKARGRGFVSGPDSLDRGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggctttgtgcagcctggggggtctctgagactctcctgtgca
gcctctggattcaccttcagtagctactggatgtattgggtccgtcaggctccagggaag
gggctcgagtgggtctcagttatcgattccggtggtagtagcacaaactatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacgctgtatctgcaaatg
aacagtctgagatctgcggacacggccgtgtattactgtgccaaagcgagagggagaggg
tttgtttctgggccggactctctggaccggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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