abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCEASGRTFS	1 - 27	27
CDR-H1	SYHMG	28 - 32	5
HFR2	WFRQAAGKEREFVA	33 - 46	14
CDR-H2	TISSDYNTYYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTVYLQTNSLKPEDTAVYYCAS	63 - 94	32
CDR-H3	RTVFSGPQYYTRAHEYGY	95 - 112	18
HFR4	WGQGTQVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCEAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCEAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCEASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCEASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCEAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSSY---	23 - 29	7
	AbM	GRTFSSYHMG	23 - 32	10
	Kabat	-----SYHMG	28 - 32	5
	Contact	----SSYHMG	27 - 32	6
	IMGT	GRTFSSYH--	23 - 30	8
HFR2	Chothia	HMGWFRQAAGKEREFVATI	30 - 48	19
	AbM	---WFRQAAGKEREFVA--	33 - 46	14
	Kabat	---WFRQAAGKEREFVA--	33 - 46	14
	Contact	---WFRQAAGKERE-----	33 - 43	11
	IMGT	-MGWFRQAAGKEREFVAT-	31 - 47	17
CDR-H2	Chothia	-----SSDYN---------	49 - 53	5
	AbM	---TISSDYNTY-------	47 - 55	9
	Kabat	---TISSDYNTYYADSVKG	47 - 62	16
	Contact	FVATISSDYNTY-------	44 - 55	12
	IMGT	----ISSDYNT--------	48 - 54	7
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVYLQTNSLKPEDTAVYYCAS	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQTNSLKPEDTAVYYCAS	56 - 94	39
	Kabat	---------RFTISRDNAKNTVYLQTNSLKPEDTAVYYCAS	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQTNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQTNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--RTVFSGPQYYTRAHEYGY	95 - 112	18
	AbM	--RTVFSGPQYYTRAHEYGY	95 - 112	18
	Kabat	--RTVFSGPQYYTRAHEYGY	95 - 112	18
	Contact	ASRTVFSGPQYYTRAHEYG-	93 - 111	19
	IMGT	ASRTVFSGPQYYTRAHEYGY	93 - 112	20
HFR4	Chothia	-WGQGTQVT	113 - 120	8
	AbM	-WGQGTQVT	113 - 120	8
	Kabat	-WGQGTQVT	113 - 120	8
	Contact	YWGQGTQVT	112 - 120	9
	IMGT	-WGQGTQVT	113 - 120	8

Accession & Annotations

Accession	CAH18009.1
Source	abYsis-EMBL-IG AJ810806 Submitted 18-AUG-2004 Updated 22-NOV-2005
Name	immunoglobulin heavy chain variable region
Clone	K27
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Hoogendoorn A., van Zijderveld F.G., Niewold T.A., van der Meulen J. 'Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea' Vet. Microbiol. 111(1-2):89-98(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCEASGRTFSSYHMGWFRQAAGKEREFVATISSDYNTYYADSV
KGRFTISRDNAKNTVYLQTNSLKPEDTAVYYCASRTVFSGPQYYTRAHEYGYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggccgggggctctctgaggctctcctgtgaa
gcctctggacgcaccttcagtagctatcacatgggctggtttcgccaggctgcagggaag
gagcgtgagtttgtagctactattagcagcgattataacacatattatgcagactccgtg
aagggccgattcaccatctccagagacaacgccaagaatacggtgtatctgcaaacgaac
agcctgaaacctgaggacacggccgtttattactgtgcatcacgtacagtatttagtgga
ccgcagtattacacccgtgcacatgagtatggctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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