abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGGTFS	1 - 27	27
CDR-H1	WYAMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	TVSRGGGSTYYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAAYYCAA	64 - 95	32
CDR-H3	GRGSPSDTGRPDEYDY	96 - 111	16
HFR4	WGQGTQVT	112 - 119	8
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGGTFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGGTF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GGTFSWY---	23 - 29	7
	AbM	GGTFSWYAMG	23 - 32	10
	Kabat	-----WYAMG	28 - 32	5
	Contact	----SWYAMG	27 - 32	6
	IMGT	GGTFSWYA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREFVATV	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAT-	31 - 47	17
CDR-H2	Chothia	-----SRGGGS---------	49 - 54	6
	AbM	---TVSRGGGSTY-------	47 - 56	10
	Kabat	---TVSRGGGSTYYADSVKG	47 - 63	17
	Contact	FVATVSRGGGSTY-------	44 - 56	13
	IMGT	----VSRGGGST--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAAYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAAYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAAYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAAYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAAYYC--	56 - 93	38
CDR-H3	Chothia	--GRGSPSDTGRPDEYDY	96 - 111	16
	AbM	--GRGSPSDTGRPDEYDY	96 - 111	16
	Kabat	--GRGSPSDTGRPDEYDY	96 - 111	16
	Contact	AAGRGSPSDTGRPDEYD-	94 - 110	17
	IMGT	AAGRGSPSDTGRPDEYDY	94 - 111	18
HFR4	Chothia	-WGQGTQVT	112 - 119	8
	AbM	-WGQGTQVT	112 - 119	8
	Kabat	-WGQGTQVT	112 - 119	8
	Contact	YWGQGTQVT	111 - 119	9
	IMGT	-WGQGTQVT	112 - 119	8

Accession & Annotations

Accession	CAH18010.1
Source	abYsis-EMBL-IG AJ810807 Submitted 18-AUG-2004 Updated 22-NOV-2005
Name	immunoglobulin heavy chain variable region
Clone	K609
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Hoogendoorn A., van Zijderveld F.G., Niewold T.A., van der Meulen J. 'Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea' Vet. Microbiol. 111(1-2):89-98(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGGTFSWYAMGWFRQAPGKEREFVATVSRGGGSTYYADS
VKGRFTISRDNAKNTVYLQMNSLKPEDTAAYYCAAGRGSPSDTGRPDEYDYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggaggcaccttcagttggtatgccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcaactgtcagcaggggtggcggtagtacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacagcctgaaacccgaggacacggccgcttattactgtgcagcaggtagaggtagtcca
agcgacaccgggcggccggatgagtatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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