abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGRLVEAGGSLRLSCAVSGGTFS	1 - 27	27
CDR-H1	WYAMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	TVSRGGGASYYADSVKD	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNGLKYEDTAVYYCAA	64 - 95	32
CDR-H3	GRGAPSDTGRPDEYDY	96 - 111	16
HFR4	WGQGTQVT	112 - 119	8
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGRLVEAGGSLRLSCAVS-----	1 - 22	22
	AbM	LQESGGRLVEAGGSLRLSCAVS-----	1 - 22	22
	Kabat	LQESGGRLVEAGGSLRLSCAVSGGTFS	1 - 27	27
	Contact	LQESGGRLVEAGGSLRLSCAVSGGTF-	1 - 26	26
	IMGT	LQESGGRLVEAGGSLRLSCAVS-----	1 - 22	22
CDR-H1	Chothia	GGTFSWY---	23 - 29	7
	AbM	GGTFSWYAMG	23 - 32	10
	Kabat	-----WYAMG	28 - 32	5
	Contact	----SWYAMG	27 - 32	6
	IMGT	GGTFSWYA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREFVATV	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAT-	31 - 47	17
CDR-H2	Chothia	-----SRGGGA---------	49 - 54	6
	AbM	---TVSRGGGASY-------	47 - 56	10
	Kabat	---TVSRGGGASYYADSVKD	47 - 63	17
	Contact	FVATVSRGGGASY-------	44 - 56	13
	IMGT	----VSRGGGAS--------	48 - 55	8
HFR3	Chothia	SYYADSVKDRFTISRDNAKNTVYLQMNGLKYEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKDRFTISRDNAKNTVYLQMNGLKYEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNGLKYEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKDRFTISRDNAKNTVYLQMNGLKYEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKDRFTISRDNAKNTVYLQMNGLKYEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GRGAPSDTGRPDEYDY	96 - 111	16
	AbM	--GRGAPSDTGRPDEYDY	96 - 111	16
	Kabat	--GRGAPSDTGRPDEYDY	96 - 111	16
	Contact	AAGRGAPSDTGRPDEYD-	94 - 110	17
	IMGT	AAGRGAPSDTGRPDEYDY	94 - 111	18
HFR4	Chothia	-WGQGTQVT	112 - 119	8
	AbM	-WGQGTQVT	112 - 119	8
	Kabat	-WGQGTQVT	112 - 119	8
	Contact	YWGQGTQVT	111 - 119	9
	IMGT	-WGQGTQVT	112 - 119	8

Accession & Annotations

Accession	CAH18011.1
Source	abYsis-EMBL-IG AJ810808 Submitted 18-AUG-2004 Updated 22-NOV-2005
Name	immunoglobulin heavy chain variable region
Clone	K719
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Hoogendoorn A., van Zijderveld F.G., Niewold T.A., van der Meulen J. 'Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea' Vet. Microbiol. 111(1-2):89-98(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGRLVEAGGSLRLSCAVSGGTFSWYAMGWFRQAPGKEREFVATVSRGGGASYYADS
VKDRFTISRDNAKNTVYLQMNGLKYEDTAVYYCAAGRGAPSDTGRPDEYDYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggacgattggtggaggctgggggctctctgagactctcctgtgca
gtctctggaggcacctttagttggtacgccatggggtggttccgccaggctccaggaaag
gagcgcgagtttgtagcaactgtcagcaggggtggcggtgcttcatactatgcagactcc
gtgaaggaccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacggcctgaaatacgaggacacggccgtctattactgtgcagcaggtagaggtgctcca
agcgacaccgggcggccggatgagtatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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