abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGSDFS	1 - 27	27
CDR-H1	ATAMT	28 - 32	5
HFR2	WYRQPPGKSREYVA	33 - 46	14
CDR-H2	RIFLSGGTNYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTFYLQMNNLKREDTAVYYCNL	63 - 94	32
CDR-H3	ASY	95 - 97	3
HFR4	WGQGTQVT	98 - 105	8
			105

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGSDFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGSDF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSDFSAT---	23 - 29	7
	AbM	GSDFSATAMT	23 - 32	10
	Kabat	-----ATAMT	28 - 32	5
	Contact	----SATAMT	27 - 32	6
	IMGT	GSDFSATA--	23 - 30	8
HFR2	Chothia	AMTWYRQPPGKSREYVARI	30 - 48	19
	AbM	---WYRQPPGKSREYVA--	33 - 46	14
	Kabat	---WYRQPPGKSREYVA--	33 - 46	14
	Contact	---WYRQPPGKSRE-----	33 - 43	11
	IMGT	-MTWYRQPPGKSREYVAR-	31 - 47	17
CDR-H2	Chothia	-----FLSGG---------	49 - 53	5
	AbM	---RIFLSGGTN-------	47 - 55	9
	Kabat	---RIFLSGGTNYADSVKG	47 - 62	16
	Contact	YVARIFLSGGTN-------	44 - 55	12
	IMGT	----IFLSGGT--------	48 - 54	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTFYLQMNNLKREDTAVYYCNL	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTFYLQMNNLKREDTAVYYCNL	56 - 94	39
	Kabat	---------RFTISRDNAKNTFYLQMNNLKREDTAVYYCNL	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTFYLQMNNLKREDTAVYYC--	56 - 92	37
	IMGT	-NYADSVKGRFTISRDNAKNTFYLQMNNLKREDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--ASY	95 - 97	3
	AbM	--ASY	95 - 97	3
	Kabat	--ASY	95 - 97	3
	Contact	NLAS-	93 - 96	4
	IMGT	NLASY	93 - 97	5
HFR4	Chothia	-WGQGTQVT	98 - 105	8
	AbM	-WGQGTQVT	98 - 105	8
	Kabat	-WGQGTQVT	98 - 105	8
	Contact	YWGQGTQVT	97 - 105	9
	IMGT	-WGQGTQVT	98 - 105	8

Accession & Annotations

Accession	CAH18013.1
Source	abYsis-EMBL-IG AJ810810 Submitted 18-AUG-2004 Updated 22-NOV-2005
Name	immunoglobulin heavy chain variable region
Clone	K812
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Hoogendoorn A., van Zijderveld F.G., Niewold T.A., van der Meulen J. 'Escherichia coli F4 fimbriae specific llama single-domain antibody fragments effectively inhibit bacterial adhesion in vitro but poorly protect against diarrhoea' Vet. Microbiol. 111(1-2):89-98(2005).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGSDFSATAMTWYRQPPGKSREYVARIFLSGGTNYADSV
KGRFTISRDNAKNTFYLQMNNLKREDTAVYYCNLASYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggaagcgacttcagtgctactgccatgacctggtaccgccagcctccaggaaag
tcgcgcgagtacgtcgcacgtatattccttagtggtggcacaaactatgcagactccgtg
aagggccgattcaccatctccagagacaacgccaagaacaccttctatctgcaaatgaac
aacctgaaacgtgaggacacggccgtctattactgtaatctcgcatcctactggggccag
gggacccaggtcacc

Data Source:

Alignment settings:

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