abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGSIFS	1 - 27	27
CDR-H1	PNDMG	28 - 32	5
HFR2	WYRQAPGLLRELVA	33 - 46	14
CDR-H2	RIDYSGHTTYADSVKG	47 - 62	16
HFR3	RFTISRDTTKKTMYLEMNSLKPEDSGVYYCGL	63 - 94	32
CDR-H3	FSKWSSDY	95 - 102	8
HFR4	WGQGTQVT	103 - 110	8
			110

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGSIFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGSIF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSIFSPN---	23 - 29	7
	AbM	GSIFSPNDMG	23 - 32	10
	Kabat	-----PNDMG	28 - 32	5
	Contact	----SPNDMG	27 - 32	6
	IMGT	GSIFSPND--	23 - 30	8
HFR2	Chothia	DMGWYRQAPGLLRELVARI	30 - 48	19
	AbM	---WYRQAPGLLRELVA--	33 - 46	14
	Kabat	---WYRQAPGLLRELVA--	33 - 46	14
	Contact	---WYRQAPGLLRE-----	33 - 43	11
	IMGT	-MGWYRQAPGLLRELVAR-	31 - 47	17
CDR-H2	Chothia	-----DYSGH---------	49 - 53	5
	AbM	---RIDYSGHTT-------	47 - 55	9
	Kabat	---RIDYSGHTTYADSVKG	47 - 62	16
	Contact	LVARIDYSGHTT-------	44 - 55	12
	IMGT	----IDYSGHT--------	48 - 54	7
HFR3	Chothia	TTYADSVKGRFTISRDTTKKTMYLEMNSLKPEDSGVYYCGL	54 - 94	41
	AbM	--YADSVKGRFTISRDTTKKTMYLEMNSLKPEDSGVYYCGL	56 - 94	39
	Kabat	---------RFTISRDTTKKTMYLEMNSLKPEDSGVYYCGL	63 - 94	32
	Contact	--YADSVKGRFTISRDTTKKTMYLEMNSLKPEDSGVYYC--	56 - 92	37
	IMGT	-TYADSVKGRFTISRDTTKKTMYLEMNSLKPEDSGVYYC--	55 - 92	38
CDR-H3	Chothia	--FSKWSSDY	95 - 102	8
	AbM	--FSKWSSDY	95 - 102	8
	Kabat	--FSKWSSDY	95 - 102	8
	Contact	GLFSKWSSD-	93 - 101	9
	IMGT	GLFSKWSSDY	93 - 102	10
HFR4	Chothia	-WGQGTQVT	103 - 110	8
	AbM	-WGQGTQVT	103 - 110	8
	Kabat	-WGQGTQVT	103 - 110	8
	Contact	YWGQGTQVT	102 - 110	9
	IMGT	-WGQGTQVT	103 - 110	8

Accession & Annotations

Accession	CAH18850.1
Source	abYsis-EMBL-IG AJ811554 Submitted 20-AUG-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	M174
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (19-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., Van Solt C.B., Van Keulen L. 'Selection of llama single-domain antibody fragments binding to recombinant bovine prion protein in ELISA' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGSIFSPNDMGWYRQAPGLLRELVARIDYSGHTTYADSV
KGRFTISRDTTKKTMYLEMNSLKPEDSGVYYCGLFSKWSSDYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggatctatcttcagtcccaatgacatgggctggtaccgccaggctccagggctg
ctgcgcgagttggtcgcacgtatagattatagtggacatacaacctatgcagactccgtg
aagggccgattcaccatctccagagacaccaccaagaaaacaatgtatcttgaaatgaac
agcctgaaacctgaggactcgggcgtctattattgtgggctctttagtaagtggtcctct
gactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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