abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGDSLRLSCAASGRTGN	1 - 27	27
CDR-H1	INTMT	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	GVTWGGWSGGTTDYADSVKD	47 - 66	20
HFR3	RFTISRDGAKNTMYLQMNSLKFEDTAVYYCAA	67 - 98	32
CDR-H3	DSKYYTVYRSRVTYEY	99 - 114	16
HFR4	WGQGTQVT	115 - 122	8
			122

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGDSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGDSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGDSLRLSCAASGRTGN	1 - 27	27
	Contact	LQESGGGLVQAGDSLRLSCAASGRTG-	1 - 26	26
	IMGT	LQESGGGLVQAGDSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTGNIN---	23 - 29	7
	AbM	GRTGNINTMT	23 - 32	10
	Kabat	-----INTMT	28 - 32	5
	Contact	----NINTMT	27 - 32	6
	IMGT	GRTGNINT--	23 - 30	8
HFR2	Chothia	TMTWFRQAPGKEREFVAGV	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MTWFRQAPGKEREFVAG-	31 - 47	17
CDR-H2	Chothia	-----TWGGWSGGT---------	49 - 57	9
	AbM	---GVTWGGWSGGTTD-------	47 - 59	13
	Kabat	---GVTWGGWSGGTTDYADSVKD	47 - 66	20
	Contact	FVAGVTWGGWSGGTTD-------	44 - 59	16
	IMGT	----VTWGGWSGGTT--------	48 - 58	11
HFR3	Chothia	TDYADSVKDRFTISRDGAKNTMYLQMNSLKFEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKDRFTISRDGAKNTMYLQMNSLKFEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDGAKNTMYLQMNSLKFEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKDRFTISRDGAKNTMYLQMNSLKFEDTAVYYC--	60 - 96	37
	IMGT	-DYADSVKDRFTISRDGAKNTMYLQMNSLKFEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DSKYYTVYRSRVTYEY	99 - 114	16
	AbM	--DSKYYTVYRSRVTYEY	99 - 114	16
	Kabat	--DSKYYTVYRSRVTYEY	99 - 114	16
	Contact	AADSKYYTVYRSRVTYE-	97 - 113	17
	IMGT	AADSKYYTVYRSRVTYEY	97 - 114	18
HFR4	Chothia	-WGQGTQVT	115 - 122	8
	AbM	-WGQGTQVT	115 - 122	8
	Kabat	-WGQGTQVT	115 - 122	8
	Contact	YWGQGTQVT	114 - 122	9
	IMGT	-WGQGTQVT	115 - 122	8

Accession & Annotations

Accession	CAH18851.1
Source	abYsis-EMBL-IG AJ811555 Submitted 20-AUG-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	M176
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (19-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., Van Solt C.B., Van Keulen L. 'Selection of llama single-domain antibody fragments binding to recombinant bovine prion protein in ELISA' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGDSLRLSCAASGRTGNINTMTWFRQAPGKEREFVAGVTWGGWSGGTTDY
ADSVKDRFTISRDGAKNTMYLQMNSLKFEDTAVYYCAADSKYYTVYRSRVTYEYWGQGTQ
VT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctggggactctctgagactctcctgtgca
gcctctggacgtaccggcaatatcaataccatgacctggttccgccaggctccagggaag
gagcgtgaatttgtagcaggagtgacctggggtggctggagtggtggtactaccgactat
gcagactccgtgaaggaccgattcaccatctctagagacggcgccaagaacacaatgtat
ctgcaaatgaacagcctgaaatttgaggacacggccgtttattactgtgcagcagactcc
aaatactatactgtgtatagatcccgggtgacgtatgagtactggggccaggggacccag
gtcacc

Data Source:

Alignment settings:

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