abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGDSLRLSCQASGITFS	1 - 27	27
CDR-H1	LYTMG	28 - 32	5
HFR2	WFRQAPGKEREFVS	33 - 46	14
CDR-H2	AITWTGSSTYYADSVKD	47 - 63	17
HFR3	RFTTSRDIAKKTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	GYRIDTQPMDRDFYYY	96 - 111	16
HFR4	WGQGTQVT	112 - 119	8
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGDSLRLSCQAS-----	1 - 22	22
	AbM	LQESGGGLVQAGDSLRLSCQAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGDSLRLSCQASGITFS	1 - 27	27
	Contact	LQESGGGLVQAGDSLRLSCQASGITF-	1 - 26	26
	IMGT	LQESGGGLVQAGDSLRLSCQAS-----	1 - 22	22
CDR-H1	Chothia	GITFSLY---	23 - 29	7
	AbM	GITFSLYTMG	23 - 32	10
	Kabat	-----LYTMG	28 - 32	5
	Contact	----SLYTMG	27 - 32	6
	IMGT	GITFSLYT--	23 - 30	8
HFR2	Chothia	TMGWFRQAPGKEREFVSAI	30 - 48	19
	AbM	---WFRQAPGKEREFVS--	33 - 46	14
	Kabat	---WFRQAPGKEREFVS--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVSA-	31 - 47	17
CDR-H2	Chothia	-----TWTGSS---------	49 - 54	6
	AbM	---AITWTGSSTY-------	47 - 56	10
	Kabat	---AITWTGSSTYYADSVKD	47 - 63	17
	Contact	FVSAITWTGSSTY-------	44 - 56	13
	IMGT	----ITWTGSST--------	48 - 55	8
HFR3	Chothia	TYYADSVKDRFTTSRDIAKKTVYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKDRFTTSRDIAKKTVYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTTSRDIAKKTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKDRFTTSRDIAKKTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKDRFTTSRDIAKKTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GYRIDTQPMDRDFYYY	96 - 111	16
	AbM	--GYRIDTQPMDRDFYYY	96 - 111	16
	Kabat	--GYRIDTQPMDRDFYYY	96 - 111	16
	Contact	AAGYRIDTQPMDRDFYY-	94 - 110	17
	IMGT	AAGYRIDTQPMDRDFYYY	94 - 111	18
HFR4	Chothia	-WGQGTQVT	112 - 119	8
	AbM	-WGQGTQVT	112 - 119	8
	Kabat	-WGQGTQVT	112 - 119	8
	Contact	YWGQGTQVT	111 - 119	9
	IMGT	-WGQGTQVT	112 - 119	8

Accession & Annotations

Accession	CAH18862.1
Source	abYsis-EMBL-IG AJ811566 Submitted 20-AUG-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	M220
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (19-AUG-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., Van Solt C.B., Van Keulen L. 'Selection of llama single-domain antibody fragments binding to recombinant bovine prion protein in ELISA' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGDSLRLSCQASGITFSLYTMGWFRQAPGKEREFVSAITWTGSSTYYADS
VKDRFTTSRDIAKKTVYLQMNSLKPEDTAVYYCAAGYRIDTQPMDRDFYYYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctggggactctctgagactctcctgtcaa
gcctcgggtattaccttcagtttatataccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtgtcagctattacctggactggaagtagcacatactatgcagactcc
gtgaaggaccgattcaccacctccagagacatcgccaagaaaacggtgtaccttcaaatg
aacagcctgaaacctgaggacacggccgtttattactgtgcagcgggataccgcattgat
actcaacctatggaccgtgacttctattactattggggccaggggactcaggtcacc

Data Source:

Alignment settings:

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