abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASGRAFG	1 - 27	27
CDR-H1	YYYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRSLTVVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASGRAFG	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASGRAF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRAFGYY---	23 - 29	7
	AbM	GRAFGYYYMG	23 - 32	10
	Kabat	-----YYYMG	28 - 32	5
	Contact	----GYYYMG	27 - 32	6
	IMGT	GRAFGYYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRSLTVVASSWRY	96 - 108	13
	AbM	--DRSLTVVASSWRY	96 - 108	13
	Kabat	--DRSLTVVASSWRY	96 - 108	13
	Contact	AGDRSLTVVASSWR-	94 - 107	14
	IMGT	AGDRSLTVVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAH60895.1
Source	abYsis-EMBL-IG AJ849380 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	M3
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., Van Solt C.B., Van Keulen L. 'Selection of llama single-domain antibody fragments binding to recombinant bovine prion protein in ELISA' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASGRAFGYYYMGWFRQAPGKEREFVAAISWYDGSTSYADS
VKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAGDRSLTVVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgggccttcggatactattacatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattagctggtatgatggtagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtggatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgcaggagatcgtagtttgacg
gtagtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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