abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRDFS	1 - 27	27
CDR-H1	TYALA	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AITWTGGSTYYADSVEG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	DLPPYGSSWYPPRYDY	96 - 111	16
HFR4	WGQGTQVT	112 - 119	8
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRDFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRDF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRDFSTY---	23 - 29	7
	AbM	GRDFSTYALA	23 - 32	10
	Kabat	-----TYALA	28 - 32	5
	Contact	----STYALA	27 - 32	6
	IMGT	GRDFSTYA--	23 - 30	8
HFR2	Chothia	ALAWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-LAWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----TWTGGS---------	49 - 54	6
	AbM	---AITWTGGSTY-------	47 - 56	10
	Kabat	---AITWTGGSTYYADSVEG	47 - 63	17
	Contact	FVAAITWTGGSTY-------	44 - 56	13
	IMGT	----ITWTGGST--------	48 - 55	8
HFR3	Chothia	TYYADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DLPPYGSSWYPPRYDY	96 - 111	16
	AbM	--DLPPYGSSWYPPRYDY	96 - 111	16
	Kabat	--DLPPYGSSWYPPRYDY	96 - 111	16
	Contact	AADLPPYGSSWYPPRYD-	94 - 110	17
	IMGT	AADLPPYGSSWYPPRYDY	94 - 111	18
HFR4	Chothia	-WGQGTQVT	112 - 119	8
	AbM	-WGQGTQVT	112 - 119	8
	Kabat	-WGQGTQVT	112 - 119	8
	Contact	YWGQGTQVT	111 - 119	9
	IMGT	-WGQGTQVT	112 - 119	8

Accession & Annotations

Accession	CAH60900.1
Source	abYsis-EMBL-IG AJ849385 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	PR5
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., Van Solt C.B., Van Keulen L. 'Selection of llama single-domain antibody fragments binding to recombinant bovine prion protein in ELISA' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRDFSTYALAWFRQAPGKEREFVAAITWTGGSTYYADS
VEGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAADLPPYGSSWYPPRYDYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcgacttcagtacctatgccctggcctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattacctggactggtggtagcacatactatgcagactcc
gtggagggccgattcaccatctccagagacaacgccaagaacacggtatatctgcaaatg
aacagcctgaaacctgaggacacggccgtttattactgtgcagcagacttacccccatac
ggtagtagttggtatcctccgcgatatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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