abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGSSFS	1 - 27	27
CDR-H1	IRTMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWSGGNTYYTDFVKG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAIYYCAA	64 - 95	32
CDR-H3	GFAYRSVTYSSRPSFYEY	96 - 113	18
HFR4	WGQGTQVT	114 - 121	8
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGSSFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGSSF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSSFSIR---	23 - 29	7
	AbM	GSSFSIRTMG	23 - 32	10
	Kabat	-----IRTMG	28 - 32	5
	Contact	----SIRTMG	27 - 32	6
	IMGT	GSSFSIRT--	23 - 30	8
HFR2	Chothia	TMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWSGGN---------	49 - 54	6
	AbM	---AISWSGGNTY-------	47 - 56	10
	Kabat	---AISWSGGNTYYTDFVKG	47 - 63	17
	Contact	FVAAISWSGGNTY-------	44 - 56	13
	IMGT	----ISWSGGNT--------	48 - 55	8
HFR3	Chothia	TYYTDFVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYCAA	55 - 95	41
	AbM	--YTDFVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAIYYCAA	64 - 95	32
	Contact	--YTDFVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYC--	57 - 93	37
	IMGT	-YYTDFVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYC--	56 - 93	38
CDR-H3	Chothia	--GFAYRSVTYSSRPSFYEY	96 - 113	18
	AbM	--GFAYRSVTYSSRPSFYEY	96 - 113	18
	Kabat	--GFAYRSVTYSSRPSFYEY	96 - 113	18
	Contact	AAGFAYRSVTYSSRPSFYE-	94 - 112	19
	IMGT	AAGFAYRSVTYSSRPSFYEY	94 - 113	20
HFR4	Chothia	-WGQGTQVT	114 - 121	8
	AbM	-WGQGTQVT	114 - 121	8
	Kabat	-WGQGTQVT	114 - 121	8
	Contact	YWGQGTQVT	113 - 121	9
	IMGT	-WGQGTQVT	114 - 121	8

Accession & Annotations

Accession	CAH60922.1
Source	abYsis-EMBL-IG AJ849407 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	PR46
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., Van Solt C.B., Van Keulen L. 'Selection of llama single-domain antibody fragments binding to recombinant bovine prion protein in ELISA' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGSSFSIRTMGWFRQAPGKEREFVAAISWSGGNTYYTDF
VKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYCAAGFAYRSVTYSSRPSFYEYWGQGTQV
T

DNA Sequence:

ctgcaggagtcagggggaggcttggtgcaggctggggggtctctgagactctcctgtgca
gcgtctggaagcagcttcagtatccggaccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagcaattagctggagtggtggtaacacatactatacagacttc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacagcctgaaacctgaggacacggccatttattactgtgcagcagggttcgcataccgt
agtgttacctattcctcgcgaccctctttctatgagtactggggccaggggacccaggtc
acc

Data Source:

Alignment settings:

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